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UniProtKB - Q9CRB8 (MTFP1_MOUSE)
Protein
Mitochondrial fission process protein 1
Gene
Mtfp1
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
By similarityGO - Biological processi
- apoptotic process Source: MGI
- mitochondrial fission Source: UniProtKB
- mitochondrial membrane organization Source: MGI
- mitochondrion organization Source: MGI
- response to muscle activity Source: Ensembl
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial fission process protein 1Alternative name(s): Mitochondrial 18 kDa protein Short name: MTP18 |
Gene namesi | Name:Mtfp1 Synonyms:Mtp18 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916686, Mtfp1 |
VEuPathDBi | HostDB:ENSMUSG00000004748 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212412 | 1 – 166 | Mitochondrial fission process protein 1Add BLAST | 166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 123 | N6-succinyllysineCombined sources | 1 |
Proteomic databases
jPOSTi | Q9CRB8 |
MaxQBi | Q9CRB8 |
PaxDbi | Q9CRB8 |
PRIDEi | Q9CRB8 |
ProteomicsDBi | 291433 |
PTM databases
PhosphoSitePlusi | Q9CRB8 |
SwissPalmi | Q9CRB8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004748, Expressed in heart left ventricle and 278 other tissues |
Genevisiblei | Q9CRB8, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 212524, 1 interactor |
IntActi | Q9CRB8, 1 interactor |
STRINGi | 10090.ENSMUSP00000004868 |
Miscellaneous databases
RNActi | Q9CRB8, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the MTFP1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3945, Eukaryota |
GeneTreei | ENSGT00390000004019 |
HOGENOMi | CLU_053720_1_0_1 |
InParanoidi | Q9CRB8 |
OMAi | DVFTWQM |
OrthoDBi | 1477184at2759 |
PhylomeDBi | Q9CRB8 |
TreeFami | TF324605 |
Family and domain databases
InterProi | View protein in InterPro IPR019560, Mitochondrial_18_kDa_protein |
PANTHERi | PTHR11001, PTHR11001, 1 hit |
Pfami | View protein in Pfam PF10558, MTP18, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9CRB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEQQRQGAE RDLYRDTWVR YLGYANEVGE AFRSLVPAAV VWLSYGVSSS
60 70 80 90 100
YVLADAIDKG KKAGEVPSPE AGRNTRMALA VVDTFVWQSL ASVAIPGFTI
110 120 130 140 150
NRLCAASLYV LGTMTHWPPT VRKWTTTTLG LLAIPVIIHP IDRSVDFLLD
160
SSLRKLYPSV EKPSTP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | S → N in BAB27999 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK006148 mRNA Translation: BAB24432.1 AK010971 mRNA Translation: BAB27300.1 AK012058 mRNA Translation: BAB27999.1 AK078381 mRNA Translation: BAC37244.1 BC058737 mRNA Translation: AAH58737.1 |
CCDSi | CCDS24376.1 |
RefSeqi | NP_080719.2, NM_026443.4 |
Genome annotation databases
Ensembli | ENSMUST00000004868; ENSMUSP00000004868; ENSMUSG00000004748 |
GeneIDi | 67900 |
KEGGi | mmu:67900 |
UCSCi | uc007hug.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK006148 mRNA Translation: BAB24432.1 AK010971 mRNA Translation: BAB27300.1 AK012058 mRNA Translation: BAB27999.1 AK078381 mRNA Translation: BAC37244.1 BC058737 mRNA Translation: AAH58737.1 |
CCDSi | CCDS24376.1 |
RefSeqi | NP_080719.2, NM_026443.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 212524, 1 interactor |
IntActi | Q9CRB8, 1 interactor |
STRINGi | 10090.ENSMUSP00000004868 |
PTM databases
PhosphoSitePlusi | Q9CRB8 |
SwissPalmi | Q9CRB8 |
Proteomic databases
jPOSTi | Q9CRB8 |
MaxQBi | Q9CRB8 |
PaxDbi | Q9CRB8 |
PRIDEi | Q9CRB8 |
ProteomicsDBi | 291433 |
Protocols and materials databases
Antibodypediai | 34826, 107 antibodies from 21 providers |
DNASUi | 67900 |
Genome annotation databases
Ensembli | ENSMUST00000004868; ENSMUSP00000004868; ENSMUSG00000004748 |
GeneIDi | 67900 |
KEGGi | mmu:67900 |
UCSCi | uc007hug.1, mouse |
Organism-specific databases
CTDi | 51537 |
MGIi | MGI:1916686, Mtfp1 |
VEuPathDBi | HostDB:ENSMUSG00000004748 |
Phylogenomic databases
eggNOGi | KOG3945, Eukaryota |
GeneTreei | ENSGT00390000004019 |
HOGENOMi | CLU_053720_1_0_1 |
InParanoidi | Q9CRB8 |
OMAi | DVFTWQM |
OrthoDBi | 1477184at2759 |
PhylomeDBi | Q9CRB8 |
TreeFami | TF324605 |
Miscellaneous databases
BioGRID-ORCSi | 67900, 2 hits in 63 CRISPR screens |
ChiTaRSi | Mtfp1, mouse |
PROi | PR:Q9CRB8 |
RNActi | Q9CRB8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004748, Expressed in heart left ventricle and 278 other tissues |
Genevisiblei | Q9CRB8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019560, Mitochondrial_18_kDa_protein |
PANTHERi | PTHR11001, PTHR11001, 1 hit |
Pfami | View protein in Pfam PF10558, MTP18, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MTFP1_MOUSE | |
Accessioni | Q9CRB8Primary (citable) accession number: Q9CRB8 Secondary accession number(s): Q9CZX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families