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Protein

Calcium-regulated heat stable protein 1

Gene

Carhsp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds mRNA and regulates the stability of target mRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of mRNA stability Source: UniProtKB
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-regulated heat stable protein 1
Alternative name(s):
Calcium-regulated heat-stable protein of 24 kDa
Short name:
CRHSP-24
Gene namesi
Name:Carhsp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1196368 Carhsp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001002312 – 148Calcium-regulated heat stable protein 1Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei46PhosphothreonineBy similarity1
Modified residuei53PhosphoserineBy similarity1
Modified residuei59PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1

Post-translational modificationi

Can be phosphorylated by DYRK2 (in vitro). Dephosphorylated by calcineurin in a Ca2+ dependent manner (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CR86
MaxQBiQ9CR86
PaxDbiQ9CR86
PRIDEiQ9CR86

PTM databases

iPTMnetiQ9CR86
PhosphoSitePlusiQ9CR86

Expressioni

Gene expression databases

BgeeiENSMUSG00000008393
CleanExiMM_CARHSP1
ExpressionAtlasiQ9CR86 baseline and differential
GenevisibleiQ9CR86 MM

Interactioni

Subunit structurei

Homodimer. Interacts with STYX (By similarity).By similarity

Protein-protein interaction databases

BioGridi206625, 1 interactor
IntActiQ9CR86, 2 interactors
MINTiQ9CR86
STRINGi10090.ENSMUSP00000008537

Structurei

3D structure databases

ProteinModelPortaliQ9CR86
SMRiQ9CR86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 130CSDAdd BLAST68

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ9CR86
OMAiCTIPPKN
OrthoDBiEOG091G0TYX
PhylomeDBiQ9CR86
TreeFamiTF324381

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEPPPPPL QPPTHQTSVG LLDTPRTRDR SPSPLRGNVV PSPLPTRRTR
60 70 80 90 100
TFSATVRASQ GPVYKGVCKC FCRSKGHGFI TPADGGPDIF LHISDVEGEY
110 120 130 140
VPVEGDEVTY KMCSIPPKNE KLQAVEVVIT HLAPGTKHET WSGHVISN
Length:148
Mass (Da):16,062
Last modified:June 1, 2001 - v1
Checksum:i117F3FE85D11BC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414101 mRNA Translation: AAL07470.1
AK004711 mRNA Translation: BAB23495.1
AK002853 mRNA Translation: BAB22408.1
AK003926 mRNA Translation: BAB23077.1
BC011225 mRNA Translation: AAH11225.1
CCDSiCCDS27942.1
RefSeqiNP_080097.1, NM_025821.2
XP_006522409.2, XM_006522346.2
UniGeneiMm.142095

Genome annotation databases

EnsembliENSMUST00000008537; ENSMUSP00000008537; ENSMUSG00000008393
GeneIDi52502
KEGGimmu:52502
UCSCiuc007yct.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCHSP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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