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Protein

Protein FAM32A

Gene

Fam32a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May induce G2 arrest and apoptosis (By similarity). May also increase cell sensitivity to apoptotic stimuli (By similarity). In cell lines, may play a role in the inhibition of anchor-independent cell growth.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM32A
Alternative name(s):
Ovarian tumor associated gene 12
Short name:
OTAG-12
Gene namesi
Name:Fam32a
Synonyms:Otag12
ORF Names:MNCb-3154
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915172 Fam32a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232511 – 112Protein FAM32AAdd BLAST112

Proteomic databases

EPDiQ9CR80
MaxQBiQ9CR80
PaxDbiQ9CR80
PeptideAtlasiQ9CR80
PRIDEiQ9CR80

PTM databases

iPTMnetiQ9CR80
PhosphoSitePlusiQ9CR80

Expressioni

Tissue specificityi

Widely expressed, with highest level in pancreas and lowest in muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000003039 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_2510049I19RIK
GenevisibleiQ9CR80 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CR80, 3 interactors
MINTiQ9CR80
STRINGi10090.ENSMUSP00000003123

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 86Lys-richAdd BLAST78

Sequence similaritiesi

Belongs to the FAM32 family.Curated

Phylogenomic databases

eggNOGiKOG3410 Eukaryota
ENOG41126B2 LUCA
GeneTreeiENSGT00390000013811
HOVERGENiHBG081504
InParanoidiQ9CR80
KOiK13120
OMAiLSEHNDM
OrthoDBiEOG091G1285
PhylomeDBiQ9CR80
TreeFamiTF314020

Family and domain databases

InterProiView protein in InterPro
IPR013865 DUF1754_euk
PANTHERiPTHR13282 PTHR13282, 1 hit
PfamiView protein in Pfam
PF08555 DUF1754, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKMLEA MGTSKKSEEE
60 70 80 90 100
KRRCLDKRTP AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT
110
EHYDIPKVSW TK
Length:112
Mass (Da):13,215
Last modified:June 1, 2001 - v1
Checksum:i14CEF0C40B3DAD48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → P in BAB93548 (Ref. 1) Curated1
Sequence conflicti37M → V in BAB93548 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041658 mRNA Translation: BAB93548.1
AK008285 mRNA Translation: BAB25576.1
AK011922 mRNA Translation: BAB27918.1
AK075976 mRNA Translation: BAC36089.1
AK082792 mRNA Translation: BAC38622.1
AK150416 mRNA Translation: BAE29540.1
BC006058 mRNA Translation: AAH06058.1
CCDSiCCDS52595.1
RefSeqiNP_080731.1, NM_026455.4
UniGeneiMm.28327

Genome annotation databases

EnsembliENSMUST00000003123; ENSMUSP00000003123; ENSMUSG00000003039
GeneIDi67922
KEGGimmu:67922
UCSCiuc009mfn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041658 mRNA Translation: BAB93548.1
AK008285 mRNA Translation: BAB25576.1
AK011922 mRNA Translation: BAB27918.1
AK075976 mRNA Translation: BAC36089.1
AK082792 mRNA Translation: BAC38622.1
AK150416 mRNA Translation: BAE29540.1
BC006058 mRNA Translation: AAH06058.1
CCDSiCCDS52595.1
RefSeqiNP_080731.1, NM_026455.4
UniGeneiMm.28327

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CR80, 3 interactors
MINTiQ9CR80
STRINGi10090.ENSMUSP00000003123

PTM databases

iPTMnetiQ9CR80
PhosphoSitePlusiQ9CR80

Proteomic databases

EPDiQ9CR80
MaxQBiQ9CR80
PaxDbiQ9CR80
PeptideAtlasiQ9CR80
PRIDEiQ9CR80

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003123; ENSMUSP00000003123; ENSMUSG00000003039
GeneIDi67922
KEGGimmu:67922
UCSCiuc009mfn.1 mouse

Organism-specific databases

CTDi26017
MGIiMGI:1915172 Fam32a

Phylogenomic databases

eggNOGiKOG3410 Eukaryota
ENOG41126B2 LUCA
GeneTreeiENSGT00390000013811
HOVERGENiHBG081504
InParanoidiQ9CR80
KOiK13120
OMAiLSEHNDM
OrthoDBiEOG091G1285
PhylomeDBiQ9CR80
TreeFamiTF314020

Miscellaneous databases

ChiTaRSiFam32a mouse
PROiPR:Q9CR80
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003039 Expressed in 289 organ(s), highest expression level in blood
CleanExiMM_2510049I19RIK
GenevisibleiQ9CR80 MM

Family and domain databases

InterProiView protein in InterPro
IPR013865 DUF1754_euk
PANTHERiPTHR13282 PTHR13282, 1 hit
PfamiView protein in Pfam
PF08555 DUF1754, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA32A_MOUSE
AccessioniPrimary (citable) accession number: Q9CR80
Secondary accession number(s): Q8K5E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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