Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich nuclear receptor coactivator 2

Gene

Pnrc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (By similarity). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (By similarity). Required for UPF1/RENT1 localization to the P-body (By similarity). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (PubMed:17971453).By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processNonsense-mediated mRNA decay, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich nuclear receptor coactivator 2
Gene namesi
Name:Pnrc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:106512 Pnrc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are lean, resistant to high fat diet-induced obesity but without the induction of insulin resistance and have a higher metabolic rate than wild-type mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584861 – 140Proline-rich nuclear receptor coactivator 2Add BLAST140

Proteomic databases

PaxDbiQ9CR73
PRIDEiQ9CR73

PTM databases

iPTMnetiQ9CR73
PhosphoSitePlusiQ9CR73

Expressioni

Tissue specificityi

Strong expression is detected in lung, spleen, ovary, thymus, and colon.1 Publication

Gene expression databases

BgeeiENSMUSG00000028675 Expressed in 294 organ(s), highest expression level in pituitary gland
CleanExiMM_PNRC2
ExpressionAtlasiQ9CR73 baseline and differential
GenevisibleiQ9CR73 MM

Interactioni

Subunit structurei

Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030436

Structurei

3D structure databases

ProteinModelPortaliQ9CR73
SMRiQ9CR73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi100 – 106SH3-binding7

Domaini

The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.By similarity

Sequence similaritiesi

Belongs to the PNRC family. PNRC2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IY3T Eukaryota
ENOG4112BTC LUCA
GeneTreeiENSGT00530000063881
HOGENOMiHOG000115593
HOVERGENiHBG053627
InParanoidiQ9CR73
KOiK18751
OMAiERGHTYN
OrthoDBiEOG091G0SY3
PhylomeDBiQ9CR73

Family and domain databases

InterProiView protein in InterPro
IPR026780 PNRC1/2
IPR026781 PNRC2
PANTHERiPTHR15405 PTHR15405, 1 hit
PTHR15405:SF6 PTHR15405:SF6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CR73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGGERYNIP DPQSRNASKN QEQQNRQKSK DQNSSQTKIA HKKKERGHGY
60 70 80 90 100
NPAAAAWQAM QNGGKTKSLS NNSNWNAGLS SPSLLFKSQA SQNYAGAKFS
110 120 130 140
EPPSPSVLPK PPSHWVHVSL NPSDKETMTF QLKTLLKVQV
Length:140
Mass (Da):15,401
Last modified:June 1, 2001 - v1
Checksum:i17321057158B36B3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YMU7Z4YMU7_MOUSE
Proline-rich nuclear receptor coact...
Pnrc2
37Annotation score:
J3QJZ8J3QJZ8_MOUSE
Proline-rich nuclear receptor coact...
Pnrc2
56Annotation score:

Sequence cautioni

The sequence CAM15897 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98K → Q in BAB31186 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011192 mRNA Translation: BAB27457.1
AK012073 mRNA Translation: BAB28010.1
AK013163 mRNA Translation: BAB28686.1
AK018384 mRNA Translation: BAB31186.1
AK075816 mRNA Translation: BAC35983.1
AK077403 mRNA Translation: BAC36786.1
AL672076 Genomic DNA Translation: CAM15896.1
AL672076 Genomic DNA Translation: CAM15897.1 Sequence problems.
CH466552 Genomic DNA Translation: EDL29966.1
BC006598 mRNA Translation: AAH06598.1
CCDSiCCDS18792.1
RefSeqiNP_080659.1, NM_026383.3
XP_006539101.1, XM_006539038.1
XP_006539102.1, XM_006539039.1
UniGeneiMm.29159

Genome annotation databases

EnsembliENSMUST00000030436; ENSMUSP00000030436; ENSMUSG00000028675
GeneIDi52830
KEGGimmu:52830
UCSCiuc008vhf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011192 mRNA Translation: BAB27457.1
AK012073 mRNA Translation: BAB28010.1
AK013163 mRNA Translation: BAB28686.1
AK018384 mRNA Translation: BAB31186.1
AK075816 mRNA Translation: BAC35983.1
AK077403 mRNA Translation: BAC36786.1
AL672076 Genomic DNA Translation: CAM15896.1
AL672076 Genomic DNA Translation: CAM15897.1 Sequence problems.
CH466552 Genomic DNA Translation: EDL29966.1
BC006598 mRNA Translation: AAH06598.1
CCDSiCCDS18792.1
RefSeqiNP_080659.1, NM_026383.3
XP_006539101.1, XM_006539038.1
XP_006539102.1, XM_006539039.1
UniGeneiMm.29159

3D structure databases

ProteinModelPortaliQ9CR73
SMRiQ9CR73
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030436

PTM databases

iPTMnetiQ9CR73
PhosphoSitePlusiQ9CR73

Proteomic databases

PaxDbiQ9CR73
PRIDEiQ9CR73

Protocols and materials databases

DNASUi52830
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030436; ENSMUSP00000030436; ENSMUSG00000028675
GeneIDi52830
KEGGimmu:52830
UCSCiuc008vhf.2 mouse

Organism-specific databases

CTDi55629
MGIiMGI:106512 Pnrc2

Phylogenomic databases

eggNOGiENOG410IY3T Eukaryota
ENOG4112BTC LUCA
GeneTreeiENSGT00530000063881
HOGENOMiHOG000115593
HOVERGENiHBG053627
InParanoidiQ9CR73
KOiK18751
OMAiERGHTYN
OrthoDBiEOG091G0SY3
PhylomeDBiQ9CR73

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiPnrc2 mouse
PROiPR:Q9CR73
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028675 Expressed in 294 organ(s), highest expression level in pituitary gland
CleanExiMM_PNRC2
ExpressionAtlasiQ9CR73 baseline and differential
GenevisibleiQ9CR73 MM

Family and domain databases

InterProiView protein in InterPro
IPR026780 PNRC1/2
IPR026781 PNRC2
PANTHERiPTHR15405 PTHR15405, 1 hit
PTHR15405:SF6 PTHR15405:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNRC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR73
Secondary accession number(s): B1AV48, B1AV49, Q9CXC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again