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Protein

Growth arrest and DNA damage-inducible proteins-interacting protein 1

Gene

Gadd45gip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.By similarity

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible proteins-interacting protein 1
Alternative name(s):
39S ribosomal protein L59, mitochondrial
Short name:
MRP-L59
Gene namesi
Name:Gadd45gip1
Synonyms:Mrpl59
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914947 Gadd45gip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002286211 – 222Growth arrest and DNA damage-inducible proteins-interacting protein 1Add BLAST222

Proteomic databases

EPDiQ9CR59
MaxQBiQ9CR59
PaxDbiQ9CR59
PeptideAtlasiQ9CR59
PRIDEiQ9CR59

PTM databases

iPTMnetiQ9CR59
PhosphoSitePlusiQ9CR59

Expressioni

Gene expression databases

BgeeiENSMUSG00000033751 Expressed in 255 organ(s), highest expression level in primary oocyte
GenevisibleiQ9CR59 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with ATAD3A and ATAD3B.By similarity

Protein-protein interaction databases

DIPiDIP-61653N
IntActiQ9CR59, 1 interactor
MINTiQ9CR59
STRINGi10090.ENSMUSP00000037783

Structurei

3D structure databases

ProteinModelPortaliQ9CR59
SMRiQ9CR59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 207Sequence analysisAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi184 – 200Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 31Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4848 Eukaryota
ENOG410XVD1 LUCA
GeneTreeiENSGT00390000013719
HOGENOMiHOG000112686
HOVERGENiHBG068845
InParanoidiQ9CR59
OMAiAEEREWY
OrthoDBiEOG091G158K
PhylomeDBiQ9CR59
TreeFamiTF323794

Family and domain databases

InterProiView protein in InterPro
IPR018472 Damage-induce-interacting_prot
PANTHERiPTHR31761 PTHR31761, 1 hit
PfamiView protein in Pfam
PF10147 CR6_interact, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALAMRSGY LLRLSVALGP RSRSYRAPPP PRRRPGPHSP DPENLLTPRW
60 70 80 90 100
QLTPRYVAKQ FGRHGAISGV PPASLWPTPE QLRELEAEEQ EWYPSLATMQ
110 120 130 140 150
ESLRLQQQAL EARRQAREQR IAECMAKMPQ MIENWRKQKR ERWEKIQADK
160 170 180 190 200
ERRARLQAEA QERLGYHVDP RSARFQELLQ DLDKQQRKRL KEERQRQKKE
210 220
ARIAAMASAE AQDSAVSGEP SS
Length:222
Mass (Da):25,820
Last modified:June 1, 2001 - v1
Checksum:i1CB0F5AF4ACFF504
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184K → Q in BAC25826 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002738 mRNA Translation: BAB22318.1
AK003314 mRNA Translation: BAB22710.1
AK028227 mRNA Translation: BAC25826.1
AK009723 mRNA Translation: BAB26464.1
AK019570 mRNA Translation: BAB31797.1
BC061069 mRNA Translation: AAH61069.1
CCDSiCCDS22478.1
RefSeqiNP_899202.3, NM_183358.4
UniGeneiMm.489649

Genome annotation databases

EnsembliENSMUST00000036734; ENSMUSP00000037783; ENSMUSG00000033751
GeneIDi102060
KEGGimmu:102060
UCSCiuc009mnj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002738 mRNA Translation: BAB22318.1
AK003314 mRNA Translation: BAB22710.1
AK028227 mRNA Translation: BAC25826.1
AK009723 mRNA Translation: BAB26464.1
AK019570 mRNA Translation: BAB31797.1
BC061069 mRNA Translation: AAH61069.1
CCDSiCCDS22478.1
RefSeqiNP_899202.3, NM_183358.4
UniGeneiMm.489649

3D structure databases

ProteinModelPortaliQ9CR59
SMRiQ9CR59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61653N
IntActiQ9CR59, 1 interactor
MINTiQ9CR59
STRINGi10090.ENSMUSP00000037783

PTM databases

iPTMnetiQ9CR59
PhosphoSitePlusiQ9CR59

Proteomic databases

EPDiQ9CR59
MaxQBiQ9CR59
PaxDbiQ9CR59
PeptideAtlasiQ9CR59
PRIDEiQ9CR59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036734; ENSMUSP00000037783; ENSMUSG00000033751
GeneIDi102060
KEGGimmu:102060
UCSCiuc009mnj.1 mouse

Organism-specific databases

CTDi90480
MGIiMGI:1914947 Gadd45gip1

Phylogenomic databases

eggNOGiKOG4848 Eukaryota
ENOG410XVD1 LUCA
GeneTreeiENSGT00390000013719
HOGENOMiHOG000112686
HOVERGENiHBG068845
InParanoidiQ9CR59
OMAiAEEREWY
OrthoDBiEOG091G158K
PhylomeDBiQ9CR59
TreeFamiTF323794

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q9CR59
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033751 Expressed in 255 organ(s), highest expression level in primary oocyte
GenevisibleiQ9CR59 MM

Family and domain databases

InterProiView protein in InterPro
IPR018472 Damage-induce-interacting_prot
PANTHERiPTHR31761 PTHR31761, 1 hit
PfamiView protein in Pfam
PF10147 CR6_interact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG45IP_MOUSE
AccessioniPrimary (citable) accession number: Q9CR59
Secondary accession number(s): Q8BT05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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