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Protein

Kidney mitochondrial carrier protein 1

Gene

Slc25a30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.24.2 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Kidney mitochondrial carrier protein 1
Alternative name(s):
Solute carrier family 25 member 30
Gene namesi
Name:Slc25a30
Synonyms:Kmcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914804 Slc25a30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 26Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei71 – 89Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei106 – 124Helical; Name=3Sequence analysisAdd BLAST19
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei264 – 283Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002889182 – 291Kidney mitochondrial carrier protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CR58
MaxQBiQ9CR58
PaxDbiQ9CR58
PRIDEiQ9CR58

PTM databases

PhosphoSitePlusiQ9CR58

Expressioni

Tissue specificityi

Present in kidney (at protein level). Expressed predominantly within the kidney cortex in the proximal and distal tubules and at lower levels in the testis and white adipose tissue.1 Publication

Inductioni

Up-regulated during fasting and in the regenerative phase following renal tubular injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000022003
CleanExiMM_SLC25A30
GenevisibleiQ9CR58 MM

Interactioni

Subunit structurei

Interacts with VDAC1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022580

Structurei

3D structure databases

ProteinModelPortaliQ9CR58
SMRiQ9CR58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 96Solcar 1Add BLAST90
Repeati104 – 189Solcar 2Add BLAST86
Repeati198 – 289Solcar 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiQ9CR58
KOiK15106
OMAiSITAECG
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9CR58
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DANFREIRYR
60 70 80 90 100
GMLHALMRIG REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLAVER
110 120 130 140 150
PEDETLLVNV VCGILSGVIS SAIANPTDVL KIRMQAQNSA VQGGMIDSFM
160 170 180 190 200
SIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL PVYDITKKHL ILSGLMGDTV
210 220 230 240 250
ATHFLSSFTC GLVGALASNP VDVVRTRMMN QRALRDGRCA GYKGTLDCLL
260 270 280 290
QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF LTYEQLKKLD L
Length:291
Mass (Da):32,282
Last modified:June 1, 2001 - v1
Checksum:i1CD3138F9FF27B99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17I → M in BAE30385 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015679 mRNA Translation: BAB29928.1
AK017035 mRNA Translation: BAB30563.1
AK151334 mRNA Translation: BAE30312.1
AK151420 mRNA Translation: BAE30385.1
AK159122 mRNA Translation: BAE34837.1
AK159732 mRNA Translation: BAE35326.1
CCDSiCCDS27281.1
RefSeqiNP_080508.1, NM_026232.3
UniGeneiMm.46067

Genome annotation databases

EnsembliENSMUST00000022580; ENSMUSP00000022580; ENSMUSG00000022003
GeneIDi67554
KEGGimmu:67554
UCSCiuc007uqx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKMCP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR58
Secondary accession number(s): Q3UAD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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