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Protein

60S ribosomal protein L14

Gene

Rpl14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14
Gene namesi
Name:Rpl14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914365 Rpl14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001320321 – 21760S ribosomal protein L14Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei85N6-acetyllysine; alternateCombined sources1
Modified residuei85N6-succinyllysine; alternateCombined sources1
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei139PhosphoserineCombined sources1
Modified residuei206N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CR57
MaxQBiQ9CR57
PaxDbiQ9CR57
PeptideAtlasiQ9CR57
PRIDEiQ9CR57
TopDownProteomicsiQ9CR57

PTM databases

iPTMnetiQ9CR57
PhosphoSitePlusiQ9CR57
SwissPalmiQ9CR57

Expressioni

Gene expression databases

BgeeiENSMUSG00000025794
CleanExiMM_RPL14
ExpressionAtlasiQ9CR57 baseline and differential
GenevisibleiQ9CR57 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211949, 5 interactors
CORUMiQ9CR57
IntActiQ9CR57, 6 interactors
MINTiQ9CR57
STRINGi10090.ENSMUSP00000131489

Structurei

3D structure databases

ProteinModelPortaliQ9CR57
SMRiQ9CR57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati173 – 1771-1; approximate5
Repeati178 – 1821-25
Repeati183 – 1871-35
Repeati188 – 1921-45
Repeati195 – 1972-13
Repeati198 – 2002-23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 1924 X 5 AA tandem repeats of Q-K-A-[APS]-XAdd BLAST20
Regioni195 – 2002 X 3 AA tandem repeats of K-G-Q6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3421 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000007888
HOGENOMiHOG000201693
HOVERGENiHBG005187
InParanoidiQ9CR57
KOiK02875
OMAiMAMKRIA
OrthoDBiEOG091G0VTN
TreeFamiTF314356

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR014722 Rib_L2_dom2
IPR002784 Ribosomal_L14e_dom
IPR008991 Translation_prot_SH3-like_sf
PfamiView protein in Pfam
PF01929 Ribosomal_L14e, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRRYVEVG RVAYISFGPH AGKLVAIVDV IDQNRALVDG PCTRVRRQAM
60 70 80 90 100
PFKCMQLTDF ILKFPHSARQ KYVRKAWEKA DINTKWAATR WAKKIDARER
110 120 130 140 150
KAKMTDFDRF KVMKAKKMRN RIIKTEVKKL QRAAILKASP KKAAVAKAAI
160 170 180 190 200
AAAAAAAAAK AKVPAKKATG PGKKAAGQKA PAQKAAGQKA APPAKGQKGQ
210
KTPAQKAPAP KAAGKKA
Length:217
Mass (Da):23,564
Last modified:January 23, 2007 - v3
Checksum:i1DB57CAA155D05A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → T in BAB25272 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007807 mRNA Translation: BAB25272.1
AK012277 mRNA Translation: BAB28136.1
AK013912 mRNA Translation: BAB29051.1
CCDSiCCDS40809.1
RefSeqiNP_080250.1, NM_025974.2
UniGeneiMm.289810

Genome annotation databases

EnsembliENSMUST00000165532; ENSMUSP00000131489; ENSMUSG00000025794
GeneIDi67115
KEGGimmu:67115
UCSCiuc009scr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRL14_MOUSE
AccessioniPrimary (citable) accession number: Q9CR57
Secondary accession number(s): Q9D8Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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