Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RING finger and CHY zinc finger domain-containing protein 1

Gene

Rchy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression.By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi6.3.2.19 3474
ReactomeiR-MMU-110320 Translesion Synthesis by POLH
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger and CHY zinc finger domain-containing protein 1 (EC:2.3.2.27)
Alternative name(s):
Androgen receptor N-terminal-interacting protein
CH-rich-interacting match with PLAG1
E3 ubiquitin-protein ligase Pirh2
RING-type E3 ubiquitin transferase RCHY1
Zinc finger protein 363
Gene namesi
Name:Rchy1
Synonyms:Arnip, Chimp, Zfp363, Znf363
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915348 Rchy1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563131 – 261RING finger and CHY zinc finger domain-containing protein 1Add BLAST261

Post-translational modificationi

Subject to ubiquitination and proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9CR50
MaxQBiQ9CR50
PaxDbiQ9CR50
PeptideAtlasiQ9CR50
PRIDEiQ9CR50

PTM databases

PhosphoSitePlusiQ9CR50

Expressioni

Tissue specificityi

Detected in testis, liver, kidney and heart.1 Publication

Inductioni

Up-regulated upon p53/TP53 activation.1 Publication

Gene expression databases

BgeeiENSMUSG00000029397 Expressed in 279 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ9CR50 baseline and differential
GenevisibleiQ9CR50 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212655, 3 interactors
STRINGi10090.ENSMUSP00000031345

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9CR50
SMRiQ9CR50
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CR50

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 80CHY-typePROSITE-ProRule annotationAdd BLAST68
Zinc fingeri82 – 144CTCHY-typePROSITE-ProRule annotationAdd BLAST63
Zinc fingeri145 – 189RING-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1940 Eukaryota
ENOG410XXHF LUCA
GeneTreeiENSGT00390000008853
HOGENOMiHOG000231827
HOVERGENiHBG062959
InParanoidiQ9CR50
KOiK10144
OMAiGMKCNIC
OrthoDBiEOG091G094U
PhylomeDBiQ9CR50
TreeFamiTF323762

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039512 RCHY1_zinc-ribbon
IPR008913 Znf_CHY
IPR037274 Znf_CHY_sf
IPR017921 Znf_CTCHY
IPR037275 Znf_CTCHY_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05495 zf-CHY, 1 hit
PF13639 zf-RING_2, 1 hit
PF14599 zinc_ribbon_6, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF161219 SSF161219, 1 hit
SSF161245 SSF161245, 1 hit
PROSITEiView protein in PROSITE
PS51266 ZF_CHY, 1 hit
PS51270 ZF_CTCHY, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CR50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATAREDGV RNLAQGPRGC EHYDRACLLK APCCDKLYTC RLCHDTNEDH
60 70 80 90 100
QLDRFKVKEV QCINCEKLQH AQQTCEDCST LFGEYYCSIC HLFDKDKRQY
110 120 130 140 150
HCESCGICRI GPKEDFFHCL KCNLCLTTNL RGKHKCIENV SRQNCPICLE
160 170 180 190 200
DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG YRCPLCMHSA LDMTRYWRQL
210 220 230 240 250
DTEVAQTPMP SEYQNVTVDI LCNDCNGRST VQFHILGMKC KLCDSYNTAQ
260
AGGRRVPVDQ Q
Length:261
Mass (Da):30,014
Last modified:June 1, 2001 - v1
Checksum:i219AE48A421CC10D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWD8G3UWD8_MOUSE
RING finger and CHY zinc finger dom...
Rchy1 mCG_12522
221Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071222 mRNA Translation: AAL75940.1
AF276959 mRNA Translation: AAK96899.1
AF305423 mRNA Translation: AAL09355.1
AK018364 mRNA Translation: BAB31179.1
AK018488 mRNA Translation: BAB31236.1
AK078397 mRNA Translation: BAC37254.1
BC057143 mRNA Translation: AAH57143.1
CCDSiCCDS19424.1
RefSeqiNP_001258726.1, NM_001271797.1
NP_080833.1, NM_026557.4
UniGeneiMm.159453

Genome annotation databases

EnsembliENSMUST00000031345; ENSMUSP00000031345; ENSMUSG00000029397
GeneIDi68098
KEGGimmu:68098
UCSCiuc008yby.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071222 mRNA Translation: AAL75940.1
AF276959 mRNA Translation: AAK96899.1
AF305423 mRNA Translation: AAL09355.1
AK018364 mRNA Translation: BAB31179.1
AK018488 mRNA Translation: BAB31236.1
AK078397 mRNA Translation: BAC37254.1
BC057143 mRNA Translation: AAH57143.1
CCDSiCCDS19424.1
RefSeqiNP_001258726.1, NM_001271797.1
NP_080833.1, NM_026557.4
UniGeneiMm.159453

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKTNMR-A9-138[»]
2ECMNMR-A145-186[»]
ProteinModelPortaliQ9CR50
SMRiQ9CR50
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212655, 3 interactors
STRINGi10090.ENSMUSP00000031345

PTM databases

PhosphoSitePlusiQ9CR50

Proteomic databases

EPDiQ9CR50
MaxQBiQ9CR50
PaxDbiQ9CR50
PeptideAtlasiQ9CR50
PRIDEiQ9CR50

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031345; ENSMUSP00000031345; ENSMUSG00000029397
GeneIDi68098
KEGGimmu:68098
UCSCiuc008yby.2 mouse

Organism-specific databases

CTDi25898
MGIiMGI:1915348 Rchy1

Phylogenomic databases

eggNOGiKOG1940 Eukaryota
ENOG410XXHF LUCA
GeneTreeiENSGT00390000008853
HOGENOMiHOG000231827
HOVERGENiHBG062959
InParanoidiQ9CR50
KOiK10144
OMAiGMKCNIC
OrthoDBiEOG091G094U
PhylomeDBiQ9CR50
TreeFamiTF323762

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi6.3.2.19 3474
ReactomeiR-MMU-110320 Translesion Synthesis by POLH
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiRchy1 mouse
EvolutionaryTraceiQ9CR50
PROiPR:Q9CR50
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029397 Expressed in 279 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ9CR50 baseline and differential
GenevisibleiQ9CR50 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039512 RCHY1_zinc-ribbon
IPR008913 Znf_CHY
IPR037274 Znf_CHY_sf
IPR017921 Znf_CTCHY
IPR037275 Znf_CTCHY_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05495 zf-CHY, 1 hit
PF13639 zf-RING_2, 1 hit
PF14599 zinc_ribbon_6, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SUPFAMiSSF161219 SSF161219, 1 hit
SSF161245 SSF161245, 1 hit
PROSITEiView protein in PROSITE
PS51266 ZF_CHY, 1 hit
PS51270 ZF_CTCHY, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZN363_MOUSE
AccessioniPrimary (citable) accession number: Q9CR50
Secondary accession number(s): Q920H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again