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Protein

Ribosome biogenesis protein NSA2 homolog

Gene

Nsa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein NSA2 homolog
Alternative name(s):
L-name-related protein 42
Short name:
LNR42
TGF-beta-inducible nuclear protein 1
Gene namesi
Name:Nsa2
Synonyms:Tinp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913883 Nsa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222601 – 260Ribosome biogenesis protein NSA2 homologAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei81PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CR47
MaxQBiQ9CR47
PaxDbiQ9CR47
PeptideAtlasiQ9CR47
PRIDEiQ9CR47

PTM databases

PhosphoSitePlusiQ9CR47

Expressioni

Gene expression databases

BgeeiENSMUSG00000060739 Expressed in 281 organ(s), highest expression level in skin of back
CleanExiMM_5730427N09RIK
ExpressionAtlasiQ9CR47 baseline and differential
GenevisibleiQ9CR47 MM

Interactioni

Subunit structurei

Component of the pre-66S ribosomal particle.By similarity

Protein-protein interaction databases

BioGridi208514, 1 interactor
IntActiQ9CR47, 2 interactors
MINTiQ9CR47
STRINGi10090.ENSMUSP00000073161

Structurei

3D structure databases

ProteinModelPortaliQ9CR47
SMRiQ9CR47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 18Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 152Lys-richAdd BLAST130

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3163 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000018706
HOVERGENiHBG047617
InParanoidiQ9CR47
KOiK14842
OMAiKRQKKAW
OrthoDBiEOG091G0IDG
PhylomeDBiQ9CR47
TreeFamiTF300766

Family and domain databases

CDDicd11381 NSA2, 1 hit
InterProiView protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2
PANTHERiPTHR12642 PTHR12642, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CR47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQNEYIELH RKRYGYRLDY HEKKRKKEGR EAHERSKKAK KMIGLKAKLY
60 70 80 90 100
HKQRHAEKIQ MKKTIKMHEK RNTKQKDDEK TPQGAVPAYL LDREGQSRAK
110 120 130 140 150
VLSNMIKQKR KEKAGKWEVP LPKVRAQGET EVLKVIRTGK RKKKAWKRMV
160 170 180 190 200
TKVCFVGDGF TRKPPKYERF IRPMGLRFKK AHVTHPELKA TFCLPILGVK
210 220 230 240 250
KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK YAQVTNNPEN
260
DGCINAVLLV
Length:260
Mass (Da):30,036
Last modified:June 1, 2001 - v1
Checksum:i229B1B4D8F5F8446
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCS8A0A286YCS8_MOUSE
Ribosome biogenesis protein NSA2 ho...
Nsa2
233Annotation score:

Sequence cautioni

The sequence AAF63492 differs from that shown. Reason: Frameshift at position 61.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 44MPQNE…KKMIG → MHVQRRQKNDC in BAB22128 (PubMed:16141072).CuratedAdd BLAST44
Sequence conflicti22E → G in BAC25587 (PubMed:16141072).Curated1
Sequence conflicti233G → E in BAB30834 (PubMed:16141072).Curated1
Sequence conflicti238W → C in BAB30834 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002474 mRNA Translation: BAB22128.2
AK012832 mRNA Translation: BAB28500.1
AK014275 mRNA Translation: BAB29237.1
AK017605 mRNA Translation: BAB30834.1
AK019203 mRNA Translation: BAB31599.3
AK019279 mRNA Translation: BAC25587.1
AK019379 mRNA Translation: BAB31689.1
AK078457 mRNA Translation: BAC37283.1
AF238866 mRNA Translation: AAF63492.1 Frameshift.
BC126976 mRNA Translation: AAI26977.1
CCDSiCCDS36756.1
RefSeqiNP_067527.3, NM_021552.5
UniGeneiMm.390634
Mm.422907

Genome annotation databases

EnsembliENSMUST00000073456; ENSMUSP00000073161; ENSMUSG00000060739
GeneIDi59050
KEGGimmu:59050
UCSCiuc007rns.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002474 mRNA Translation: BAB22128.2
AK012832 mRNA Translation: BAB28500.1
AK014275 mRNA Translation: BAB29237.1
AK017605 mRNA Translation: BAB30834.1
AK019203 mRNA Translation: BAB31599.3
AK019279 mRNA Translation: BAC25587.1
AK019379 mRNA Translation: BAB31689.1
AK078457 mRNA Translation: BAC37283.1
AF238866 mRNA Translation: AAF63492.1 Frameshift.
BC126976 mRNA Translation: AAI26977.1
CCDSiCCDS36756.1
RefSeqiNP_067527.3, NM_021552.5
UniGeneiMm.390634
Mm.422907

3D structure databases

ProteinModelPortaliQ9CR47
SMRiQ9CR47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208514, 1 interactor
IntActiQ9CR47, 2 interactors
MINTiQ9CR47
STRINGi10090.ENSMUSP00000073161

PTM databases

PhosphoSitePlusiQ9CR47

Proteomic databases

EPDiQ9CR47
MaxQBiQ9CR47
PaxDbiQ9CR47
PeptideAtlasiQ9CR47
PRIDEiQ9CR47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073456; ENSMUSP00000073161; ENSMUSG00000060739
GeneIDi59050
KEGGimmu:59050
UCSCiuc007rns.2 mouse

Organism-specific databases

CTDi10412
MGIiMGI:1913883 Nsa2

Phylogenomic databases

eggNOGiKOG3163 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000018706
HOVERGENiHBG047617
InParanoidiQ9CR47
KOiK14842
OMAiKRQKKAW
OrthoDBiEOG091G0IDG
PhylomeDBiQ9CR47
TreeFamiTF300766

Miscellaneous databases

PROiPR:Q9CR47
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060739 Expressed in 281 organ(s), highest expression level in skin of back
CleanExiMM_5730427N09RIK
ExpressionAtlasiQ9CR47 baseline and differential
GenevisibleiQ9CR47 MM

Family and domain databases

CDDicd11381 NSA2, 1 hit
InterProiView protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2
PANTHERiPTHR12642 PTHR12642, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSA2_MOUSE
AccessioniPrimary (citable) accession number: Q9CR47
Secondary accession number(s): A0JNU8
, Q8BHQ6, Q8BHT0, Q9CRQ0, Q9CS34, Q9CYK0, Q9JKF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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