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Protein

Ribosome biogenesis protein NSA2 homolog

Gene

Nsa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis protein NSA2 homolog
Alternative name(s):
L-name-related protein 42
Short name:
LNR42
TGF-beta-inducible nuclear protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsa2
Synonyms:Tinp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913883 Nsa2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001222601 – 260Ribosome biogenesis protein NSA2 homologAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CR47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CR47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CR47

PeptideAtlas

More...
PeptideAtlasi
Q9CR47

PRoteomics IDEntifications database

More...
PRIDEi
Q9CR47

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CR47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060739 Expressed in 281 organ(s), highest expression level in skin of back

CleanEx database of gene expression profiles

More...
CleanExi
MM_5730427N09RIK

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9CR47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CR47 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the pre-66S ribosomal particle.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208514, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9CR47, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9CR47

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000073161

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9CR47

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CR47

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi11 – 18Nuclear localization signalPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 152Lys-richAdd BLAST130

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3163 Eukaryota
COG2007 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018706

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG047617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CR47

KEGG Orthology (KO)

More...
KOi
K14842

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRQKKAW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0IDG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CR47

TreeFam database of animal gene trees

More...
TreeFami
TF300766

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11381 NSA2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2

The PANTHER Classification System

More...
PANTHERi
PTHR12642 PTHR12642, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01201 Ribosomal_S8e, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CR47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQNEYIELH RKRYGYRLDY HEKKRKKEGR EAHERSKKAK KMIGLKAKLY
60 70 80 90 100
HKQRHAEKIQ MKKTIKMHEK RNTKQKDDEK TPQGAVPAYL LDREGQSRAK
110 120 130 140 150
VLSNMIKQKR KEKAGKWEVP LPKVRAQGET EVLKVIRTGK RKKKAWKRMV
160 170 180 190 200
TKVCFVGDGF TRKPPKYERF IRPMGLRFKK AHVTHPELKA TFCLPILGVK
210 220 230 240 250
KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK YAQVTNNPEN
260
DGCINAVLLV
Length:260
Mass (Da):30,036
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i229B1B4D8F5F8446
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCS8A0A286YCS8_MOUSE
Ribosome biogenesis protein NSA2 ho...
Nsa2
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF63492 differs from that shown. Reason: Frameshift at position 61.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 44MPQNE…KKMIG → MHVQRRQKNDC in BAB22128 (PubMed:16141072).CuratedAdd BLAST44
Sequence conflicti22E → G in BAC25587 (PubMed:16141072).Curated1
Sequence conflicti233G → E in BAB30834 (PubMed:16141072).Curated1
Sequence conflicti238W → C in BAB30834 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002474 mRNA Translation: BAB22128.2
AK012832 mRNA Translation: BAB28500.1
AK014275 mRNA Translation: BAB29237.1
AK017605 mRNA Translation: BAB30834.1
AK019203 mRNA Translation: BAB31599.3
AK019279 mRNA Translation: BAC25587.1
AK019379 mRNA Translation: BAB31689.1
AK078457 mRNA Translation: BAC37283.1
AF238866 mRNA Translation: AAF63492.1 Frameshift.
BC126976 mRNA Translation: AAI26977.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36756.1

NCBI Reference Sequences

More...
RefSeqi
NP_067527.3, NM_021552.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.390634
Mm.422907

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000073456; ENSMUSP00000073161; ENSMUSG00000060739

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
59050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:59050

UCSC genome browser

More...
UCSCi
uc007rns.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002474 mRNA Translation: BAB22128.2
AK012832 mRNA Translation: BAB28500.1
AK014275 mRNA Translation: BAB29237.1
AK017605 mRNA Translation: BAB30834.1
AK019203 mRNA Translation: BAB31599.3
AK019279 mRNA Translation: BAC25587.1
AK019379 mRNA Translation: BAB31689.1
AK078457 mRNA Translation: BAC37283.1
AF238866 mRNA Translation: AAF63492.1 Frameshift.
BC126976 mRNA Translation: AAI26977.1
CCDSiCCDS36756.1
RefSeqiNP_067527.3, NM_021552.5
UniGeneiMm.390634
Mm.422907

3D structure databases

ProteinModelPortaliQ9CR47
SMRiQ9CR47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208514, 1 interactor
IntActiQ9CR47, 2 interactors
MINTiQ9CR47
STRINGi10090.ENSMUSP00000073161

PTM databases

PhosphoSitePlusiQ9CR47

Proteomic databases

EPDiQ9CR47
MaxQBiQ9CR47
PaxDbiQ9CR47
PeptideAtlasiQ9CR47
PRIDEiQ9CR47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073456; ENSMUSP00000073161; ENSMUSG00000060739
GeneIDi59050
KEGGimmu:59050
UCSCiuc007rns.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10412
MGIiMGI:1913883 Nsa2

Phylogenomic databases

eggNOGiKOG3163 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000018706
HOVERGENiHBG047617
InParanoidiQ9CR47
KOiK14842
OMAiKRQKKAW
OrthoDBiEOG091G0IDG
PhylomeDBiQ9CR47
TreeFamiTF300766

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9CR47

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060739 Expressed in 281 organ(s), highest expression level in skin of back
CleanExiMM_5730427N09RIK
ExpressionAtlasiQ9CR47 baseline and differential
GenevisibleiQ9CR47 MM

Family and domain databases

CDDicd11381 NSA2, 1 hit
InterProiView protein in InterPro
IPR039411 NSA2_fam
IPR022309 Ribosomal_S8e/biogenesis_NSA2
PANTHERiPTHR12642 PTHR12642, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSA2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CR47
Secondary accession number(s): A0JNU8
, Q8BHQ6, Q8BHT0, Q9CRQ0, Q9CS34, Q9CYK0, Q9JKF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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