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Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MoonDBiQ9CR42 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1097717 Ankrd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404801 – 319Ankyrin repeat domain-containing protein 1Add BLAST319

Proteomic databases

MaxQBiQ9CR42
PaxDbiQ9CR42
PRIDEiQ9CR42

PTM databases

iPTMnetiQ9CR42
PhosphoSitePlusiQ9CR42

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Developmental stagei

Expression was first clearly detected as early as E8.5 specifically in heart and is regulated temporally and spatially in the myocardium. Transcripts are present in uniformly high levels in the myocardium. Throughout cardiac development, expression is specific for the myocardium; endocardial cushions and valves exhibit only background levels of signal. Transcript levels persist but gradually decrease in neonatal, 2-week-old, and adult hearts.2 Publications

Gene expression databases

BgeeiENSMUSG00000024803 Expressed in 105 organ(s), highest expression level in cardiac atrium
CleanExiMM_ANKRD1
GenevisibleiQ9CR42 MM

Interactioni

Subunit structurei

Interacts with TTN/titin and YBX1.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223553, 2 interactors
IntActiQ9CR42, 29 interactors
MINTiQ9CR42
STRINGi10090.ENSMUSP00000025718

Structurei

3D structure databases

ProteinModelPortaliQ9CR42
SMRiQ9CR42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati152 – 181ANK 1Add BLAST30
Repeati185 – 214ANK 2Add BLAST30
Repeati218 – 247ANK 3Add BLAST30
Repeati251 – 280ANK 4Add BLAST30
Repeati284 – 315ANK 5Add BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 89Sequence analysisAdd BLAST37

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150856
HOGENOMiHOG000236321
HOVERGENiHBG071561
InParanoidiQ9CR42
KOiK21433
OMAiETLYSWQ
OrthoDBiEOG091G0DCN
PhylomeDBiQ9CR42
TreeFamiTF331650

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequencei

Sequence statusi: Complete.

Q9CR42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVLRVEELV TGKKNSNGAA GEFLPGEFRN GEYEAAVALE KQEDLKTLPA
60 70 80 90 100
NSVKQGEEQR KSEKLREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK
110 120 130 140 150
KTKVPVVKEP EPEIMTEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD
160 170 180 190 200
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNAD
210 220 230 240 250
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPLHDAV RLNRYKMIRL LMTFGADLKV KNCAGKTPMD LVLHWQSGTK
310
AIFDSLKENA YKNSRIATF
Length:319
Mass (Da):36,004
Last modified:June 1, 2001 - v1
Checksum:i26A3C4062CF0E7D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48L → F in BAE27549 (PubMed:16141072).Curated1
Sequence conflicti139 – 140FL → LV in AAC03533 (PubMed:9043061).Curated2
Sequence conflicti139 – 140FL → LV in AAB97080 (Ref. 4) Curated2
Sequence conflicti299T → N in BAE27316 (PubMed:16141072).Curated1
Sequence conflicti306L → P in AAC03533 (PubMed:9043061).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA Translation: AAC03533.1
AK009655 mRNA Translation: BAB26419.1
AK009959 mRNA Translation: BAB26611.1
AK145944 mRNA Translation: BAE26773.1
AK146471 mRNA Translation: BAE27197.1
AK146627 mRNA Translation: BAE27316.1
AK146940 mRNA Translation: BAE27549.1
BC037138 mRNA Translation: AAH37138.1
AF041849 mRNA Translation: AAB97080.1
CCDSiCCDS29771.1
RefSeqiNP_038496.2, NM_013468.3
UniGeneiMm.10279

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803
GeneIDi107765
KEGGimmu:107765
UCSCiuc008hhh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041847 mRNA Translation: AAC03533.1
AK009655 mRNA Translation: BAB26419.1
AK009959 mRNA Translation: BAB26611.1
AK145944 mRNA Translation: BAE26773.1
AK146471 mRNA Translation: BAE27197.1
AK146627 mRNA Translation: BAE27316.1
AK146940 mRNA Translation: BAE27549.1
BC037138 mRNA Translation: AAH37138.1
AF041849 mRNA Translation: AAB97080.1
CCDSiCCDS29771.1
RefSeqiNP_038496.2, NM_013468.3
UniGeneiMm.10279

3D structure databases

ProteinModelPortaliQ9CR42
SMRiQ9CR42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223553, 2 interactors
IntActiQ9CR42, 29 interactors
MINTiQ9CR42
STRINGi10090.ENSMUSP00000025718

Protein family/group databases

MoonDBiQ9CR42 Predicted

PTM databases

iPTMnetiQ9CR42
PhosphoSitePlusiQ9CR42

Proteomic databases

MaxQBiQ9CR42
PaxDbiQ9CR42
PRIDEiQ9CR42

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025718; ENSMUSP00000025718; ENSMUSG00000024803
GeneIDi107765
KEGGimmu:107765
UCSCiuc008hhh.1 mouse

Organism-specific databases

CTDi27063
MGIiMGI:1097717 Ankrd1

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150856
HOGENOMiHOG000236321
HOVERGENiHBG071561
InParanoidiQ9CR42
KOiK21433
OMAiETLYSWQ
OrthoDBiEOG091G0DCN
PhylomeDBiQ9CR42
TreeFamiTF331650

Miscellaneous databases

PROiPR:Q9CR42
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024803 Expressed in 105 organ(s), highest expression level in cardiac atrium
CleanExiMM_ANKRD1
GenevisibleiQ9CR42 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR42
Secondary accession number(s): O55014
, Q3UIF7, Q3UJ39, Q792Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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