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Protein

WD repeat domain phosphoinositide-interacting protein 3

Gene

Wdr45b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 3
Short name:
WIPI-3
Alternative name(s):
WD repeat-containing protein 45-like
Short name:
WDR45-like protein
WD repeat-containing protein 45B
Gene namesi
Name:Wdr45b
Synonyms:Wdr45l, Wipi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914090 Wdr45b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514461 – 344WD repeat domain phosphoinositide-interacting protein 3Add BLAST344

Proteomic databases

MaxQBiQ9CR39
PaxDbiQ9CR39
PeptideAtlasiQ9CR39
PRIDEiQ9CR39

PTM databases

iPTMnetiQ9CR39
PhosphoSitePlusiQ9CR39

Expressioni

Gene expression databases

BgeeiENSMUSG00000025173 Expressed in 38 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_WDR45L
ExpressionAtlasiQ9CR39 baseline and differential
GenevisibleiQ9CR39 MM

Interactioni

Protein-protein interaction databases

BioGridi211756, 1 interactor
STRINGi10090.ENSMUSP00000026173

Structurei

3D structure databases

ProteinModelPortaliQ9CR39
SMRiQ9CR39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati183 – 223WD 1Add BLAST41
Repeati228 – 267WD 2Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2111 Eukaryota
ENOG410XQZ6 LUCA
GeneTreeiENSGT00730000110940
HOGENOMiHOG000217543
HOVERGENiHBG053275
InParanoidiQ9CR39
OMAiYCINFNH
OrthoDBiEOG091G0EJZ
PhylomeDBiQ9CR39
TreeFamiTF314859

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CR39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL
60 70 80 90 100
EGGVGHVEML FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST
110 120 130 140 150
EVKAVKLRRD RIVVVLDSMI KVFTFTHNPH QLHVFETCYN PKGLCVLCPN
160 170 180 190 200
SNNSLLAFPG THTGHVQLVD LASTEKPPVD IPAHEGVLSC IALNLQGTRI
210 220 230 240 250
ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ DASLICVSSD
260 270 280 290 300
HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA
310 320 330 340
FGTEPNAVIA ICADGSYYKF LFSPKGECVR DVCAQFLEMT DDKL
Length:344
Mass (Da):38,021
Last modified:July 5, 2004 - v2
Checksum:i20B05342EF3DBC24
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AZP7F7AZP7_MOUSE
WD repeat domain phosphoinositide-i...
Wdr45b Wdr45l
218Annotation score:
F6RIG8F6RIG8_MOUSE
WD repeat domain phosphoinositide-i...
Wdr45b Wdr45l
172Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199R → S in BAE30843 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002352 mRNA Translation: BAB22031.2
AK013170 mRNA Translation: BAB28689.2
AK146101 mRNA Translation: BAE26902.1
AK151975 mRNA Translation: BAE30843.1
AK168603 mRNA Translation: BAE40470.1
AK170602 mRNA Translation: BAE41906.1
BC004595 mRNA Translation: AAH04595.2
CCDSiCCDS25773.1
RefSeqiNP_080069.2, NM_025793.3
UniGeneiMm.103986

Genome annotation databases

EnsembliENSMUST00000026173; ENSMUSP00000026173; ENSMUSG00000025173
GeneIDi66840
KEGGimmu:66840
UCSCiuc007mvt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002352 mRNA Translation: BAB22031.2
AK013170 mRNA Translation: BAB28689.2
AK146101 mRNA Translation: BAE26902.1
AK151975 mRNA Translation: BAE30843.1
AK168603 mRNA Translation: BAE40470.1
AK170602 mRNA Translation: BAE41906.1
BC004595 mRNA Translation: AAH04595.2
CCDSiCCDS25773.1
RefSeqiNP_080069.2, NM_025793.3
UniGeneiMm.103986

3D structure databases

ProteinModelPortaliQ9CR39
SMRiQ9CR39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211756, 1 interactor
STRINGi10090.ENSMUSP00000026173

PTM databases

iPTMnetiQ9CR39
PhosphoSitePlusiQ9CR39

Proteomic databases

MaxQBiQ9CR39
PaxDbiQ9CR39
PeptideAtlasiQ9CR39
PRIDEiQ9CR39

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026173; ENSMUSP00000026173; ENSMUSG00000025173
GeneIDi66840
KEGGimmu:66840
UCSCiuc007mvt.2 mouse

Organism-specific databases

CTDi56270
MGIiMGI:1914090 Wdr45b

Phylogenomic databases

eggNOGiKOG2111 Eukaryota
ENOG410XQZ6 LUCA
GeneTreeiENSGT00730000110940
HOGENOMiHOG000217543
HOVERGENiHBG053275
InParanoidiQ9CR39
OMAiYCINFNH
OrthoDBiEOG091G0EJZ
PhylomeDBiQ9CR39
TreeFamiTF314859

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Miscellaneous databases

PROiPR:Q9CR39
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025173 Expressed in 38 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_WDR45L
ExpressionAtlasiQ9CR39 baseline and differential
GenevisibleiQ9CR39 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWIPI3_MOUSE
AccessioniPrimary (citable) accession number: Q9CR39
Secondary accession number(s): Q3U924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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