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Protein

Gastrokine-1

Gene

Gkn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.1 Publication

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

GO - Molecular functioni

  • growth factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrokine-1
Alternative name(s):
18 kDa antrum mucosa protein
Short name:
AMP-18
Protein CA11 homolog
Gene namesi
Name:Gkn1
Synonyms:Amp18, Ca11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913533 Gkn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35By similarityAdd BLAST35
ChainiPRO_000002133336 – 201Gastrokine-1Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 157By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9CR36
PaxDbiQ9CR36
PRIDEiQ9CR36

PTM databases

PhosphoSitePlusiQ9CR36

Expressioni

Tissue specificityi

Highly expressed specifically in surface cells of the antrum mucosa from where it is secreted.1 Publication

Gene expression databases

CleanExiMM_GKN1

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032129

Structurei

3D structure databases

ProteinModelPortaliQ9CR36
SMRiQ9CR36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 165BRICHOSPROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the gastrokine family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVWS Eukaryota
ENOG410YN1G LUCA
HOGENOMiHOG000112728
HOVERGENiHBG009322
InParanoidiQ9CR36
PhylomeDBiQ9CR36

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CR36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSTPPDPL LHHTPAAMKL TMFVVGLLGL LAAPGFAYTV NINGNDGNVD
60 70 80 90 100
GSGQQSVSIN GVHNVANIDN NNGWDSWNSL WDYENSFAAT RLFSKKSCIV
110 120 130 140 150
HRMNKDAMPS LQDLDTMVKE QKGKGPGGAP PKDLMYSVNP TRVEDLNTFG
160 170 180 190 200
PKIAGMCRGI PTYVAEEIPG PNQPLYSKKC YTADILWILR MSFCGTSVET

Y
Length:201
Mass (Da):21,887
Last modified:February 10, 2009 - v2
Checksum:i012662B9A4EF83AA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53YU8Q53YU8_MOUSE
Foveolin
Gkn1 Fov, mCG_130856
184Annotation score:

Sequence cautioni

The sequence AAN75448 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25784 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25801 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25805 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25856 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25872 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB25975 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26010 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26103 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB31525 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3V → G in BAB25975 (PubMed:16141072).Curated1
Sequence conflicti3V → G in BAB26010 (PubMed:16141072).Curated1
Sequence conflicti130P → L in BAB26103 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139183 Genomic DNA Translation: AAN75448.1 Different initiation.
AK008622 mRNA Translation: BAB25784.1 Different initiation.
AK008641 mRNA Translation: BAB25801.1 Different initiation.
AK008647 mRNA Translation: BAB25805.1 Different initiation.
AK008722 mRNA Translation: BAB25856.1 Different initiation.
AK008745 mRNA Translation: BAB25872.1 Different initiation.
AK008933 mRNA Translation: BAB25975.1 Different initiation.
AK008956 mRNA No translation available.
AK008990 mRNA Translation: BAB26010.1 Different initiation.
AK009145 mRNA Translation: BAB26103.1 Different initiation.
AK019050 mRNA Translation: BAB31525.3 Different initiation.
RefSeqiNP_079742.1, NM_025466.1
UniGeneiMm.46414

Genome annotation databases

GeneIDi66283
KEGGimmu:66283
UCSCiuc009cth.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY139183 Genomic DNA Translation: AAN75448.1 Different initiation.
AK008622 mRNA Translation: BAB25784.1 Different initiation.
AK008641 mRNA Translation: BAB25801.1 Different initiation.
AK008647 mRNA Translation: BAB25805.1 Different initiation.
AK008722 mRNA Translation: BAB25856.1 Different initiation.
AK008745 mRNA Translation: BAB25872.1 Different initiation.
AK008933 mRNA Translation: BAB25975.1 Different initiation.
AK008956 mRNA No translation available.
AK008990 mRNA Translation: BAB26010.1 Different initiation.
AK009145 mRNA Translation: BAB26103.1 Different initiation.
AK019050 mRNA Translation: BAB31525.3 Different initiation.
RefSeqiNP_079742.1, NM_025466.1
UniGeneiMm.46414

3D structure databases

ProteinModelPortaliQ9CR36
SMRiQ9CR36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032129

PTM databases

PhosphoSitePlusiQ9CR36

Proteomic databases

MaxQBiQ9CR36
PaxDbiQ9CR36
PRIDEiQ9CR36

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66283
KEGGimmu:66283
UCSCiuc009cth.1 mouse

Organism-specific databases

CTDi56287
MGIiMGI:1913533 Gkn1

Phylogenomic databases

eggNOGiENOG410IVWS Eukaryota
ENOG410YN1G LUCA
HOGENOMiHOG000112728
HOVERGENiHBG009322
InParanoidiQ9CR36
PhylomeDBiQ9CR36

Miscellaneous databases

PROiPR:Q9CR36
SOURCEiSearch...

Gene expression databases

CleanExiMM_GKN1

Family and domain databases

InterProiView protein in InterPro
IPR007084 BRICHOS_dom
PfamiView protein in Pfam
PF04089 BRICHOS, 1 hit
SMARTiView protein in SMART
SM01039 BRICHOS, 1 hit
PROSITEiView protein in PROSITE
PS50869 BRICHOS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGKN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR36
Secondary accession number(s): Q9CTZ5, Q9D7K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 10, 2009
Last modified: August 30, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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