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Protein

Chymotrypsinogen B

Gene

Ctrb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

  • peptidase activity Source: MGI
  • serine-type endopeptidase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Enzyme and pathway databases

ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPSiS01.152

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:Ctrb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88559 Ctrb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000028587419 – 263Chymotrypsinogen BAdd BLAST245
ChainiPRO_000028587519 – 31Chymotrypsin B chain ABy similarityAdd BLAST13
ChainiPRO_000028587634 – 164Chymotrypsin B chain BBy similarityAdd BLAST131
ChainiPRO_0000285877167 – 263Chymotrypsin B chain CBy similarityAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Modified residuei93PhosphoserineCombined sources1
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

MaxQBiQ9CR35
PaxDbiQ9CR35
PeptideAtlasiQ9CR35
PRIDEiQ9CR35

PTM databases

iPTMnetiQ9CR35
PhosphoSitePlusiQ9CR35

Expressioni

Gene expression databases

BgeeiENSMUSG00000031957 Expressed in 41 organ(s), highest expression level in islet of Langerhans
CleanExiMM_CTRB1
GenevisibleiQ9CR35 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034435

Structurei

3D structure databases

ProteinModelPortaliQ9CR35
SMRiQ9CR35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9CR35
KOiK01310
OMAiKLAQPIN
OrthoDBiEOG091G0AH5
PhylomeDBiQ9CR35
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLWLVSCF ALVGATFGCG VPAIQPVLTG LSRIVNGEDA IPGSWPWQVS
60 70 80 90 100
LQDRTGFHFC GGSLISENWV VTAAHCGVKT TDVVVAGEFD QGSDEENVQV
110 120 130 140 150
LKIAQVFKNP KFNSFTVRND ITLLKLATPA QFSETVSAVC LPTVDDDFPA
160 170 180 190 200
GTLCATTGWG KTKYNALKTP DKLQQAALPI VSEAKCKESW GSKITDVMIC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGFCST STPAVYARVT
260
ALMPWVQEIL EAN
Length:263
Mass (Da):27,822
Last modified:June 1, 2001 - v1
Checksum:i28C4487AF1A26B27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63S → Y in BAB25112 (PubMed:16141072).Curated1
Sequence conflicti82D → N in BAB22539 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003060 mRNA Translation: BAB22539.1
AK003079 mRNA Translation: BAB22553.1
AK007566 mRNA Translation: BAB25112.1
AK007765 mRNA Translation: BAB25241.1
AK007815 mRNA Translation: BAB25280.1
AK008644 mRNA Translation: BAC25226.1
AK008729 mRNA Translation: BAB25861.1
AK008888 mRNA Translation: BAB25954.1
AK008927 mRNA Translation: BAB25971.1
BC061083 mRNA Translation: AAH61083.1
CCDSiCCDS22679.1
RefSeqiNP_079859.2, NM_025583.2
UniGeneiMm.34374

Genome annotation databases

EnsembliENSMUST00000034435; ENSMUSP00000034435; ENSMUSG00000031957
GeneIDi66473
KEGGimmu:66473
UCSCiuc009nms.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003060 mRNA Translation: BAB22539.1
AK003079 mRNA Translation: BAB22553.1
AK007566 mRNA Translation: BAB25112.1
AK007765 mRNA Translation: BAB25241.1
AK007815 mRNA Translation: BAB25280.1
AK008644 mRNA Translation: BAC25226.1
AK008729 mRNA Translation: BAB25861.1
AK008888 mRNA Translation: BAB25954.1
AK008927 mRNA Translation: BAB25971.1
BC061083 mRNA Translation: AAH61083.1
CCDSiCCDS22679.1
RefSeqiNP_079859.2, NM_025583.2
UniGeneiMm.34374

3D structure databases

ProteinModelPortaliQ9CR35
SMRiQ9CR35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034435

Protein family/group databases

MEROPSiS01.152

PTM databases

iPTMnetiQ9CR35
PhosphoSitePlusiQ9CR35

Proteomic databases

MaxQBiQ9CR35
PaxDbiQ9CR35
PeptideAtlasiQ9CR35
PRIDEiQ9CR35

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034435; ENSMUSP00000034435; ENSMUSG00000031957
GeneIDi66473
KEGGimmu:66473
UCSCiuc009nms.2 mouse

Organism-specific databases

CTDi1504
MGIiMGI:88559 Ctrb1

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9CR35
KOiK01310
OMAiKLAQPIN
OrthoDBiEOG091G0AH5
PhylomeDBiQ9CR35
TreeFamiTF330455

Enzyme and pathway databases

ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases

Miscellaneous databases

ChiTaRSiCtrb1 mouse
PROiPR:Q9CR35
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031957 Expressed in 41 organ(s), highest expression level in islet of Langerhans
CleanExiMM_CTRB1
GenevisibleiQ9CR35 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB1_MOUSE
AccessioniPrimary (citable) accession number: Q9CR35
Secondary accession number(s): Q9D8X8, Q9DC86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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