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Protein

Transmembrane protein 9

Gene

Tmem9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular transport.

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 9
Gene namesi
Name:Tmem9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913491 Tmem9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 89ExtracellularSequence analysisAdd BLAST69
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 183CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003437521 – 183Transmembrane protein 9Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei144PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9CR23
PaxDbiQ9CR23
PeptideAtlasiQ9CR23
PRIDEiQ9CR23

PTM databases

iPTMnetiQ9CR23
PhosphoSitePlusiQ9CR23

Expressioni

Gene expression databases

BgeeiENSMUSG00000026411 Expressed in 239 organ(s), highest expression level in membranous labyrinth
CleanExiMM_TMEM9
GenevisibleiQ9CR23 MM

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065409

Structurei

3D structure databases

ProteinModelPortaliQ9CR23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM9 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4007 Eukaryota
ENOG4111KV2 LUCA
GeneTreeiENSGT00390000000819
HOGENOMiHOG000044306
HOVERGENiHBG050972
InParanoidiQ9CR23
OMAiDPYTQPL
OrthoDBiEOG091G0MBS
PhylomeDBiQ9CR23
TreeFamiTF315146

Family and domain databases

InterProiView protein in InterPro
IPR008853 TMEM9
PANTHERiPTHR13064 PTHR13064, 1 hit
PfamiView protein in Pfam
PF05434 Tmemb_9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CR23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLCLVAVV GCLLVPPAQA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ
60 70 80 90 100
KDCNCLHVVE PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG
110 120 130 140 150
ALLLYMAFLM LVDPLIRKPD AYTEQLHNEE ENEDARTMAT AAASIGGPRA
160 170 180
NTVLERVEGA QQRWKLQVQE QRKTVFDRHK MLS
Length:183
Mass (Da):20,633
Last modified:June 1, 2001 - v1
Checksum:i2F906CC16C15D9A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005248 mRNA Translation: BAB23903.1
AK021225 mRNA Translation: BAB32335.1
AK134909 mRNA Translation: BAE22335.1
AK154423 mRNA Translation: BAE32575.1
BC016524 mRNA Translation: AAH16524.1
CCDSiCCDS15323.1
RefSeqiNP_001153617.1, NM_001160145.1
NP_001153618.1, NM_001160146.1
NP_079715.1, NM_025439.3
UniGeneiMm.41773

Genome annotation databases

EnsembliENSMUST00000063719; ENSMUSP00000065409; ENSMUSG00000026411
ENSMUST00000117950; ENSMUSP00000113416; ENSMUSG00000026411
ENSMUST00000165125; ENSMUSP00000128185; ENSMUSG00000026411
GeneIDi66241
KEGGimmu:66241
UCSCiuc007cue.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005248 mRNA Translation: BAB23903.1
AK021225 mRNA Translation: BAB32335.1
AK134909 mRNA Translation: BAE22335.1
AK154423 mRNA Translation: BAE32575.1
BC016524 mRNA Translation: AAH16524.1
CCDSiCCDS15323.1
RefSeqiNP_001153617.1, NM_001160145.1
NP_001153618.1, NM_001160146.1
NP_079715.1, NM_025439.3
UniGeneiMm.41773

3D structure databases

ProteinModelPortaliQ9CR23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065409

PTM databases

iPTMnetiQ9CR23
PhosphoSitePlusiQ9CR23

Proteomic databases

MaxQBiQ9CR23
PaxDbiQ9CR23
PeptideAtlasiQ9CR23
PRIDEiQ9CR23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063719; ENSMUSP00000065409; ENSMUSG00000026411
ENSMUST00000117950; ENSMUSP00000113416; ENSMUSG00000026411
ENSMUST00000165125; ENSMUSP00000128185; ENSMUSG00000026411
GeneIDi66241
KEGGimmu:66241
UCSCiuc007cue.2 mouse

Organism-specific databases

CTDi252839
MGIiMGI:1913491 Tmem9

Phylogenomic databases

eggNOGiKOG4007 Eukaryota
ENOG4111KV2 LUCA
GeneTreeiENSGT00390000000819
HOGENOMiHOG000044306
HOVERGENiHBG050972
InParanoidiQ9CR23
OMAiDPYTQPL
OrthoDBiEOG091G0MBS
PhylomeDBiQ9CR23
TreeFamiTF315146

Miscellaneous databases

ChiTaRSiTmem9 mouse
PROiPR:Q9CR23
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026411 Expressed in 239 organ(s), highest expression level in membranous labyrinth
CleanExiMM_TMEM9
GenevisibleiQ9CR23 MM

Family and domain databases

InterProiView protein in InterPro
IPR008853 TMEM9
PANTHERiPTHR13064 PTHR13064, 1 hit
PfamiView protein in Pfam
PF05434 Tmemb_9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMEM9_MOUSE
AccessioniPrimary (citable) accession number: Q9CR23
Secondary accession number(s): Q3U459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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