UniProtKB - Q9CR11 (YETS4_MOUSE)
YEATS domain-containing protein 4
Yeats4
Functioni
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity).
Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity).
Also able to recognize and bind crotonylated histone H3 (By similarity).
May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity).
Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (By similarity).
H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 73 | Interacts with diacetylated histone H3By similarity | 1 |
GO - Molecular functioni
- histone binding Source: GO_Central
- lysine-acetylated histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- protein C-terminus binding Source: MGI
GO - Biological processi
- chromatin remodeling Source: GO_Central
- histone acetylation Source: GO_Central
- histone exchange Source: ComplexPortal
- histone H2A acetylation Source: UniProtKB
- histone H4 acetylation Source: UniProtKB
- positive regulation of double-strand break repair via homologous recombination Source: MGI
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of apoptotic process Source: ComplexPortal
- regulation of cell cycle Source: MGI
- regulation of double-strand break repair Source: ComplexPortal
- regulation of growth Source: UniProtKB-KW
- regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Growth regulation, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: YEATS domain-containing protein 4CuratedAlternative name(s): Glioma-amplified sequence 41 homolog1 Publication Short name: Gas411 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927224, Yeats4 |
VEuPathDBi | HostDB:ENSMUSG00000020171 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nuclear membrane Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- nucleosome Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066205 | 1 – 227 | YEATS domain-containing protein 4Add BLAST | 227 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 37 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9CR11 |
MaxQBi | Q9CR11 |
PaxDbi | Q9CR11 |
PeptideAtlasi | Q9CR11 |
PRIDEi | Q9CR11 |
ProteomicsDBi | 299620 |
PTM databases
iPTMneti | Q9CR11 |
PhosphoSitePlusi | Q9CR11 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020171, Expressed in embryo and 299 other tissues |
Genevisiblei | Q9CR11, MM |
Interactioni
Subunit structurei
Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity.
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein.
Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
Interacts with MLLT10/AF10.
Also interacts with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1.
By similarityGO - Molecular functioni
- histone binding Source: GO_Central
- lysine-acetylated histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- protein C-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 211018, 4 interactors |
ComplexPortali | CPX-976, SRCAP chromatin remodeling complex CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q9CR11, 4 interactors |
MINTi | Q9CR11 |
STRINGi | 10090.ENSMUSP00000020382 |
Miscellaneous databases
RNActi | Q9CR11, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 158 | YEATSPROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 93 – 97 | Diacetylated histone H3 bindingBy similarity | 5 | |
Regioni | 163 – 227 | Interaction with MLLT10By similarityAdd BLAST | 65 | |
Regioni | 168 – 227 | Interaction with TACC1By similarityAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 178 – 226 | Sequence analysisAdd BLAST | 49 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000155811 |
HOGENOMi | CLU_051385_3_0_1 |
InParanoidi | Q9CR11 |
OMAi | PYHNEDM |
OrthoDBi | 1482359at2759 |
PhylomeDBi | Q9CR11 |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY
60 70 80 90 100
VKPYRNEDMS AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII
110 120 130 140 150
KIFFIDPNER PVTLYHLLKL FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM
160 170 180 190 200
MQQLLTTSRQ LTLGAYKHET EFAELEVKTR EKLEAAKKKT SFEIAELKER
210 220
LKASRETINC LKNEIRKLEE DDQTKDI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P7H0 | A0A1W2P7H0_MOUSE | YEATS domain-containing protein 4 | Yeats4 | 95 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002839 mRNA Translation: BAB22396.1 AK012096 mRNA Translation: BAB28027.1 AK010522 mRNA Translation: BAB27003.1 BC020043 mRNA Translation: AAH20043.1 |
CCDSi | CCDS24191.1 |
RefSeqi | NP_080846.1, NM_026570.4 |
Genome annotation databases
Ensembli | ENSMUST00000020382; ENSMUSP00000020382; ENSMUSG00000020171 |
GeneIDi | 64050 |
KEGGi | mmu:64050 |
UCSCi | uc007hcx.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002839 mRNA Translation: BAB22396.1 AK012096 mRNA Translation: BAB28027.1 AK010522 mRNA Translation: BAB27003.1 BC020043 mRNA Translation: AAH20043.1 |
CCDSi | CCDS24191.1 |
RefSeqi | NP_080846.1, NM_026570.4 |
3D structure databases
AlphaFoldDBi | Q9CR11 |
SMRi | Q9CR11 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211018, 4 interactors |
ComplexPortali | CPX-976, SRCAP chromatin remodeling complex CPX-990, NuA4 histone acetyltransferase complex |
IntActi | Q9CR11, 4 interactors |
MINTi | Q9CR11 |
STRINGi | 10090.ENSMUSP00000020382 |
PTM databases
iPTMneti | Q9CR11 |
PhosphoSitePlusi | Q9CR11 |
Proteomic databases
EPDi | Q9CR11 |
MaxQBi | Q9CR11 |
PaxDbi | Q9CR11 |
PeptideAtlasi | Q9CR11 |
PRIDEi | Q9CR11 |
ProteomicsDBi | 299620 |
Protocols and materials databases
Antibodypediai | 16961, 397 antibodies from 32 providers |
DNASUi | 64050 |
Genome annotation databases
Ensembli | ENSMUST00000020382; ENSMUSP00000020382; ENSMUSG00000020171 |
GeneIDi | 64050 |
KEGGi | mmu:64050 |
UCSCi | uc007hcx.2, mouse |
Organism-specific databases
CTDi | 8089 |
MGIi | MGI:1927224, Yeats4 |
VEuPathDBi | HostDB:ENSMUSG00000020171 |
Phylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000155811 |
HOGENOMi | CLU_051385_3_0_1 |
InParanoidi | Q9CR11 |
OMAi | PYHNEDM |
OrthoDBi | 1482359at2759 |
PhylomeDBi | Q9CR11 |
Enzyme and pathway databases
Reactomei | R-MMU-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 64050, 26 hits in 73 CRISPR screens |
PROi | PR:Q9CR11 |
RNActi | Q9CR11, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020171, Expressed in embryo and 299 other tissues |
Genevisiblei | Q9CR11, MM |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YETS4_MOUSE | |
Accessioni | Q9CR11Primary (citable) accession number: Q9CR11 Secondary accession number(s): Q9CW86 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot