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Protein

26S proteasome non-ATPase regulatory subunit 9

Gene

Psmd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: BHF-UCL
  • protein C-terminus binding Source: MGI
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8941858 Regulation of RUNX3 expression and activity
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 9
Alternative name(s):
26S proteasome regulatory subunit p27
Gene namesi
Name:Psmd9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914401 Psmd9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738531 – 22226S proteasome non-ATPase regulatory subunit 9Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CR00
MaxQBiQ9CR00
PaxDbiQ9CR00
PeptideAtlasiQ9CR00
PRIDEiQ9CR00

2D gel databases

REPRODUCTION-2DPAGEiQ9CR00

PTM databases

iPTMnetiQ9CR00
PhosphoSitePlusiQ9CR00
SwissPalmiQ9CR00

Expressioni

Gene expression databases

BgeeiENSMUSG00000029440
ExpressionAtlasiQ9CR00 baseline and differential
GenevisibleiQ9CR00 MM

Interactioni

Subunit structurei

Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome (By similarity).By similarity

GO - Molecular functioni

  • bHLH transcription factor binding Source: BHF-UCL
  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

BioGridi211979, 2 interactors
IntActiQ9CR00, 1 interactor
MINTiQ9CR00
STRINGi10090.ENSMUSP00000098295

Structurei

3D structure databases

ProteinModelPortaliQ9CR00
SMRiQ9CR00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 194PDZAdd BLAST87

Sequence similaritiesi

Belongs to the proteasome subunit p27 family.Curated

Phylogenomic databases

eggNOGiKOG3129 Eukaryota
COG0265 LUCA
GeneTreeiENSGT00390000004147
HOGENOMiHOG000216665
HOVERGENiHBG001851
InParanoidiQ9CR00
KOiK06693
OMAiLGCNIVP
OrthoDBiEOG091G0N53
PhylomeDBiQ9CR00
TreeFamiTF105995

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035269 PSMD9
PANTHERiPTHR12651 PTHR12651, 1 hit
PfamiView protein in Pfam
PF13180 PDZ_2, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CR00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGEDVPHRA ESSEARAAAV SDIQDLMRRK EEIEAEIKAN YDVLESQKGI
60 70 80 90 100
GMNEPLVDCE GYPRADVDLY QVRTARHNII CLQNDHKALM KQVEEALHQL
110 120 130 140 150
HARDKEKQAR DMAEAREEAM NRRLASNSPV LPQAFARVNS ISPGSPASIA
160 170 180 190 200
GLQVDDEIVE FGSVNTQNFQ SVQNVGTVVQ HSEGKPLNVT VIRRGEKHQL
210 220
RLIPTRWAGK GLLGCNIIPL QR
Length:222
Mass (Da):24,720
Last modified:June 1, 2001 - v1
Checksum:i3AC45ECAC1358C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002280 mRNA Translation: BAB21984.1
AK010276 mRNA Translation: BAB26813.1
AK168863 mRNA Translation: BAE40682.1
BC051930 mRNA Translation: AAH51930.1
BC060245 mRNA Translation: AAH60245.1
CCDSiCCDS39266.1
RefSeqiNP_080276.2, NM_026000.2
UniGeneiMm.278997

Genome annotation databases

EnsembliENSMUST00000100729; ENSMUSP00000098295; ENSMUSG00000029440
GeneIDi67151
KEGGimmu:67151
UCSCiuc008znk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPSMD9_MOUSE
AccessioniPrimary (citable) accession number: Q9CR00
Secondary accession number(s): Q3TG66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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