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Entry version 147 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

DNA-directed RNA polymerase III subunit RPC10

Gene

Polr3k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri5 – 28C4-typeSequence analysisAdd BLAST24
Zinc fingeri65 – 107TFIIS-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Transcription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC10
Short name:
RNA polymerase III subunit C10
Alternative name(s):
DNA-directed RNA polymerase III subunit K
RNA polymerase III subunit C11
Short name:
RPC11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Polr3k
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914255, Polr3k

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001214761 – 108DNA-directed RNA polymerase III subunit RPC10Add BLAST108

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CQZ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CQZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CQZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9CQZ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260923

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CQZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038628, Expressed in iris and 329 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CQZ7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211869, 12 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044582

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9CQZ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CQZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 28C4-typeSequence analysisAdd BLAST24
Zinc fingeri65 – 107TFIIS-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2906, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_093932_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CQZ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEFCDEC

Database of Orthologous Groups

More...
OrthoDBi
1508693at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CQZ7

TreeFam database of animal gene trees

More...
TreeFami
TF103031

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10509, Zn-ribbon_RPC11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034014, Zn_ribbon_RPC11_C
IPR001222, Znf_TFIIS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005586, RNApol_RpoM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS00466, ZF_TFIIS_1, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9CQZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD
60 70 80 90 100
DVLGGAAAWE NVDSTAEPCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA

QCGHRWRD
Length:108
Mass (Da):12,330
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D650FCDB48F9D1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15E → V in BAB32384 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK005152 mRNA Translation: BAB23846.1
AK010875 mRNA Translation: BAB27239.1
AK021353 mRNA Translation: BAB32384.1
AK031110 mRNA Translation: BAC27257.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17225.1

NCBI Reference Sequences

More...
RefSeqi
NP_080177.1, NM_025901.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039551; ENSMUSP00000044582; ENSMUSG00000038628

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67005

UCSC genome browser

More...
UCSCi
uc008onw.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005152 mRNA Translation: BAB23846.1
AK010875 mRNA Translation: BAB27239.1
AK021353 mRNA Translation: BAB32384.1
AK031110 mRNA Translation: BAC27257.1
CCDSiCCDS17225.1
RefSeqiNP_080177.1, NM_025901.3

3D structure databases

SMRiQ9CQZ7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211869, 12 interactors
STRINGi10090.ENSMUSP00000044582

PTM databases

PhosphoSitePlusiQ9CQZ7

Proteomic databases

EPDiQ9CQZ7
MaxQBiQ9CQZ7
PaxDbiQ9CQZ7
PRIDEiQ9CQZ7
ProteomicsDBi260923

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1811, 147 antibodies

The DNASU plasmid repository

More...
DNASUi
67005

Genome annotation databases

EnsembliENSMUST00000039551; ENSMUSP00000044582; ENSMUSG00000038628
GeneIDi67005
KEGGimmu:67005
UCSCiuc008onw.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51728
MGIiMGI:1914255, Polr3k

Phylogenomic databases

eggNOGiKOG2906, Eukaryota
GeneTreeiENSGT00550000075071
HOGENOMiCLU_093932_3_0_1
InParanoidiQ9CQZ7
OMAiMEFCDEC
OrthoDBi1508693at2759
PhylomeDBiQ9CQZ7
TreeFamiTF103031

Enzyme and pathway databases

ReactomeiR-MMU-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67005, 26 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Polr3k, mouse

Protein Ontology

More...
PROi
PR:Q9CQZ7
RNActiQ9CQZ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038628, Expressed in iris and 329 other tissues
GenevisibleiQ9CQZ7, MM

Family and domain databases

CDDicd10509, Zn-ribbon_RPC11, 1 hit
InterProiView protein in InterPro
IPR019761, DNA-dir_RNA_pol-M_15_CS
IPR001529, DNA-dir_RNA_pol_M/15kDasu
IPR012164, Rpa12/Rpb9/Rpc10/TFS
IPR034014, Zn_ribbon_RPC11_C
IPR001222, Znf_TFIIS
PfamiView protein in Pfam
PF02150, RNA_POL_M_15KD, 1 hit
PF01096, TFIIS_C, 1 hit
PIRSFiPIRSF005586, RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00661, RPOL9, 1 hit
SM00440, ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030, RNA_POL_M_15KD, 1 hit
PS00466, ZF_TFIIS_1, 1 hit
PS51133, ZF_TFIIS_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CQZ7
Secondary accession number(s): Q9D1U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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