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Protein

Claudin domain-containing protein 1

Gene

Cldnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin domain-containing protein 1
Alternative name(s):
Claudin-25
Gene namesi
Name:Cldnd1
Synonyms:Cldn25, D11Moh34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2447860 Cldnd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646951 – 253Claudin domain-containing protein 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9CQX5
PaxDbiQ9CQX5
PeptideAtlasiQ9CQX5
PRIDEiQ9CQX5

PTM databases

iPTMnetiQ9CQX5
PhosphoSitePlusiQ9CQX5
SwissPalmiQ9CQX5

Expressioni

Gene expression databases

BgeeiENSMUSG00000022744 Expressed in 283 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CLDND1
ExpressionAtlasiQ9CQX5 baseline and differential
GenevisibleiQ9CQX5 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CQX5, 1 interactor
MINTiQ9CQX5
STRINGi10090.ENSMUSP00000023426

Structurei

3D structure databases

ProteinModelPortaliQ9CQX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQW Eukaryota
ENOG4110MPF LUCA
GeneTreeiENSGT00390000002596
HOGENOMiHOG000065699
HOVERGENiHBG050817
InParanoidiQ9CQX5
OMAiFIWAART
OrthoDBiEOG091G0M8X
PhylomeDBiQ9CQX5
TreeFamiTF331244

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPIQ ENSSDSNKIA
60 70 80 90 100
WEDFLGDEAD EKTYNDVLFR YNGSLGLWRR CITIPKNTHW YAPPERTESF
110 120 130 140 150
DVVTKCMSFT LNEQFMEKYV DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL
160 170 180 190 200
MCFGALIGLC ACICRSLYPT LATGILHLLA GLCTLGSVSC YVAGIELLHQ
210 220 230 240 250
KVELPKDVSG EFGWSFCLAC VSAPLQFMAA ALFIWAAHTN RKEYTLMKAY

RVA
Length:253
Mass (Da):28,572
Last modified:June 1, 2001 - v1
Checksum:i46C1C28B0AFAC852
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY63E0CY63_MOUSE
Claudin domain-containing protein 1
Cldnd1
123Annotation score:
E0CY66E0CY66_MOUSE
Claudin domain containing 1, isofor...
Cldnd1 mCG_127941
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003808 mRNA Translation: BAB23007.1
AK009432 mRNA Translation: BAB26284.1
AK009743 mRNA Translation: BAB26473.1
AK152121 mRNA Translation: BAE30964.1
AK152722 mRNA Translation: BAE31445.1
BC055695 mRNA Translation: AAH55695.1
CCDSiCCDS28234.1
RefSeqiNP_741968.1, NM_171826.3
XP_006522157.1, XM_006522094.3
UniGeneiMm.29482
Mm.490014

Genome annotation databases

EnsembliENSMUST00000023426; ENSMUSP00000023426; ENSMUSG00000022744
ENSMUST00000162057; ENSMUSP00000125497; ENSMUSG00000022744
GeneIDi224250
KEGGimmu:224250
UCSCiuc007zoc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003808 mRNA Translation: BAB23007.1
AK009432 mRNA Translation: BAB26284.1
AK009743 mRNA Translation: BAB26473.1
AK152121 mRNA Translation: BAE30964.1
AK152722 mRNA Translation: BAE31445.1
BC055695 mRNA Translation: AAH55695.1
CCDSiCCDS28234.1
RefSeqiNP_741968.1, NM_171826.3
XP_006522157.1, XM_006522094.3
UniGeneiMm.29482
Mm.490014

3D structure databases

ProteinModelPortaliQ9CQX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQX5, 1 interactor
MINTiQ9CQX5
STRINGi10090.ENSMUSP00000023426

PTM databases

iPTMnetiQ9CQX5
PhosphoSitePlusiQ9CQX5
SwissPalmiQ9CQX5

Proteomic databases

MaxQBiQ9CQX5
PaxDbiQ9CQX5
PeptideAtlasiQ9CQX5
PRIDEiQ9CQX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023426; ENSMUSP00000023426; ENSMUSG00000022744
ENSMUST00000162057; ENSMUSP00000125497; ENSMUSG00000022744
GeneIDi224250
KEGGimmu:224250
UCSCiuc007zoc.2 mouse

Organism-specific databases

CTDi56650
MGIiMGI:2447860 Cldnd1

Phylogenomic databases

eggNOGiENOG410IFQW Eukaryota
ENOG4110MPF LUCA
GeneTreeiENSGT00390000002596
HOGENOMiHOG000065699
HOVERGENiHBG050817
InParanoidiQ9CQX5
OMAiFIWAART
OrthoDBiEOG091G0M8X
PhylomeDBiQ9CQX5
TreeFamiTF331244

Miscellaneous databases

PROiPR:Q9CQX5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022744 Expressed in 283 organ(s), highest expression level in rostral migratory stream
CleanExiMM_CLDND1
ExpressionAtlasiQ9CQX5 baseline and differential
GenevisibleiQ9CQX5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLDN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQX5
Secondary accession number(s): Q3U7C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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