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Protein

Synaptobrevin homolog YKT6

Gene

Ykt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.By similarity

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: HGNC
  • SNAP receptor activity Source: MGI
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptobrevin homolog YKT6 (EC:2.3.1.-)
Gene namesi
Name:Ykt6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927550 Ykt6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807101 – 195Synaptobrevin homolog YKT6Add BLAST195
PropeptideiPRO_0000396662196 – 198Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineBy similarity1
Lipidationi194S-palmitoyl cysteineBy similarity1
Modified residuei195Cysteine methyl esterBy similarity1
Lipidationi195S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.By similarity
Farnesylation is required for Golgi targeting.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9CQW1
MaxQBiQ9CQW1
PaxDbiQ9CQW1
PeptideAtlasiQ9CQW1
PRIDEiQ9CQW1

PTM databases

iPTMnetiQ9CQW1
PhosphoSitePlusiQ9CQW1

Expressioni

Gene expression databases

BgeeiENSMUSG00000002741 Expressed in 289 organ(s), highest expression level in neocortex
CleanExiMM_YKT6
GenevisibleiQ9CQW1 MM

Interactioni

Subunit structurei

Identified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207964, 4 interactors
IntActiQ9CQW1, 1 interactor
MINTiQ9CQW1
STRINGi10090.ENSMUSP00000002818

Structurei

3D structure databases

ProteinModelPortaliQ9CQW1
SMRiQ9CQW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 131LonginPROSITE-ProRule annotationAdd BLAST124
Domaini138 – 198v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Domaini

The longin domain regulates palmitoylation and membrane targeting.By similarity

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0861 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00390000015164
HOGENOMiHOG000189970
HOVERGENiHBG088939
InParanoidiQ9CQW1
KOiK08516
OMAiYPVRPAF
OrthoDBiEOG091G0MPE
PhylomeDBiQ9CQW1
TreeFamiTF105606

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLYSLSVLY KGDPKAVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER
60 70 80 90 100
SGKGSRASVK EQEYLCHVYV RSDSLAGVVI ADSEYPSRVA FTLLEKVLDE
110 120 130 140 150
FSKQVDRIDW PVGSPATIQY TGLDDHLSKY QNPREADPMS KVQAELDETK
160 170 180 190
IILHNTMESL LERGEKLDDL VSKSEVLGTQ SKAFYKTARK QNSCCAIM
Length:198
Mass (Da):22,314
Last modified:June 1, 2001 - v1
Checksum:i50A6E4EA7614592B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95E → D in AAC26834 (PubMed:11323436).Curated1
Sequence conflicti165E → V in AAC26834 (PubMed:11323436).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076956 mRNA Translation: AAC26834.1
AK002916 mRNA Translation: BAB22455.1
AK007486 mRNA Translation: BAB25062.1
AK147098 mRNA Translation: BAE27674.1
AK150472 mRNA Translation: BAE29589.1
AK159253 mRNA Translation: BAE34934.1
AL645469 Genomic DNA No translation available.
BC006760 mRNA Translation: AAH06760.1
CCDSiCCDS24410.1
RefSeqiNP_062635.2, NM_019661.4
UniGeneiMm.294821

Genome annotation databases

EnsembliENSMUST00000002818; ENSMUSP00000002818; ENSMUSG00000002741
GeneIDi56418
KEGGimmu:56418
UCSCiuc007hxp.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076956 mRNA Translation: AAC26834.1
AK002916 mRNA Translation: BAB22455.1
AK007486 mRNA Translation: BAB25062.1
AK147098 mRNA Translation: BAE27674.1
AK150472 mRNA Translation: BAE29589.1
AK159253 mRNA Translation: BAE34934.1
AL645469 Genomic DNA No translation available.
BC006760 mRNA Translation: AAH06760.1
CCDSiCCDS24410.1
RefSeqiNP_062635.2, NM_019661.4
UniGeneiMm.294821

3D structure databases

ProteinModelPortaliQ9CQW1
SMRiQ9CQW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207964, 4 interactors
IntActiQ9CQW1, 1 interactor
MINTiQ9CQW1
STRINGi10090.ENSMUSP00000002818

PTM databases

iPTMnetiQ9CQW1
PhosphoSitePlusiQ9CQW1

Proteomic databases

EPDiQ9CQW1
MaxQBiQ9CQW1
PaxDbiQ9CQW1
PeptideAtlasiQ9CQW1
PRIDEiQ9CQW1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002818; ENSMUSP00000002818; ENSMUSG00000002741
GeneIDi56418
KEGGimmu:56418
UCSCiuc007hxp.3 mouse

Organism-specific databases

CTDi10652
MGIiMGI:1927550 Ykt6

Phylogenomic databases

eggNOGiKOG0861 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00390000015164
HOGENOMiHOG000189970
HOVERGENiHBG088939
InParanoidiQ9CQW1
KOiK08516
OMAiYPVRPAF
OrthoDBiEOG091G0MPE
PhylomeDBiQ9CQW1
TreeFamiTF105606

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiYkt6 mouse
PROiPR:Q9CQW1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002741 Expressed in 289 organ(s), highest expression level in neocortex
CleanExiMM_YKT6
GenevisibleiQ9CQW1 MM

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYKT6_MOUSE
AccessioniPrimary (citable) accession number: Q9CQW1
Secondary accession number(s): O88595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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