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Protein

Mitochondrial import inner membrane translocase subunit TIM16

Gene

Pam16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM16
Alternative name(s):
Mitochondria-associated granulocyte macrophage CSF-signaling molecule
Presequence translocated-associated motor subunit PAM16
Gene namesi
Name:Pam16
Synonyms:Magmas, Tim16, Timm16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 10, Chromosome 16

Organism-specific databases

MGIiMGI:1913699 Pam16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140791 – 125Mitochondrial import inner membrane translocase subunit TIM16Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQV1
MaxQBiQ9CQV1
PaxDbiQ9CQV1
PeptideAtlasiQ9CQV1
PRIDEiQ9CQV1
TopDownProteomicsiQ9CQV1

PTM databases

iPTMnetiQ9CQV1
PhosphoSitePlusiQ9CQV1

Expressioni

Tissue specificityi

Expressed in trabecular bone and cartilage and by differentiated chondrocytes localized in the hypertrophic zone and by osteoblasts at early developmental stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000014301 Expressed in 21 organ(s), highest expression level in testis
ExpressionAtlasiQ9CQV1 baseline and differential
GenevisibleiQ9CQV1 MM

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity (By similarity). Associates with the TIM23 complex (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CQV1, 2 interactors
MINTiQ9CQV1
STRINGi10090.ENSMUSP00000137140

Structurei

3D structure databases

ProteinModelPortaliQ9CQV1
SMRiQ9CQV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 110J-likeAdd BLAST53

Domaini

The J-like region, although related to the J domain does not have co-chaperone activity.By similarity

Sequence similaritiesi

Belongs to the TIM16/PAM16 family.Curated

Phylogenomic databases

eggNOGiKOG3442 Eukaryota
ENOG411286G LUCA
GeneTreeiENSGT00390000012037
HOGENOMiHOG000180095
HOVERGENiHBG094040
InParanoidiQ9CQV1
KOiK17805
OMAiYKYLMEA
OrthoDBiEOG091G0ZKM
PhylomeDBiQ9CQV1
TreeFamiTF315134

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR036869 J_dom_sf
IPR005341 Tim16
PANTHERiPTHR12388 PTHR12388, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKYLAQIIV MGVQVVGRAF ARALRQEFAA SQAAADARGR AGHQSAAASN
60 70 80 90 100
LSGLSLQEAQ QILNVSKLSP EEVQKNYEHL FKVNDKSVGG SFYLQSKVVR
110 120
AKERLDEELR IQAQEDREKG QKPKT
Length:125
Mass (Da):13,785
Last modified:June 1, 2001 - v1
Checksum:i54A71AB4EEA452ED
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQA2A0A1L1SQA2_MOUSE
Predicted gene 9803
Gm9803
97Annotation score:
D6RI93D6RI93_MOUSE
Mitochondrial import inner membrane...
Pam16
39Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349454 mRNA Translation: AAL57766.1
AY320045 Genomic DNA Translation: AAQ86806.1
AB073618 mRNA Translation: BAB91135.1
AK003227 mRNA Translation: BAB22656.1
AK008380 mRNA Translation: BAB25635.1
BC024346 mRNA Translation: AAH24346.1
BC096419 mRNA Translation: AAH96419.1
CCDSiCCDS37241.1
RefSeqiNP_079847.1, NM_025571.1
UniGeneiMm.354760

Genome annotation databases

EnsembliENSMUST00000014445; ENSMUSP00000014445; ENSMUSG00000014301
ENSMUST00000057649; ENSMUSP00000137140; ENSMUSG00000045886
GeneIDi66449
KEGGimmu:66449
UCSCiuc007xzx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349454 mRNA Translation: AAL57766.1
AY320045 Genomic DNA Translation: AAQ86806.1
AB073618 mRNA Translation: BAB91135.1
AK003227 mRNA Translation: BAB22656.1
AK008380 mRNA Translation: BAB25635.1
BC024346 mRNA Translation: AAH24346.1
BC096419 mRNA Translation: AAH96419.1
CCDSiCCDS37241.1
RefSeqiNP_079847.1, NM_025571.1
UniGeneiMm.354760

3D structure databases

ProteinModelPortaliQ9CQV1
SMRiQ9CQV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQV1, 2 interactors
MINTiQ9CQV1
STRINGi10090.ENSMUSP00000137140

PTM databases

iPTMnetiQ9CQV1
PhosphoSitePlusiQ9CQV1

Proteomic databases

EPDiQ9CQV1
MaxQBiQ9CQV1
PaxDbiQ9CQV1
PeptideAtlasiQ9CQV1
PRIDEiQ9CQV1
TopDownProteomicsiQ9CQV1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014445; ENSMUSP00000014445; ENSMUSG00000014301
ENSMUST00000057649; ENSMUSP00000137140; ENSMUSG00000045886
GeneIDi66449
KEGGimmu:66449
UCSCiuc007xzx.1 mouse

Organism-specific databases

CTDi51025
MGIiMGI:1913699 Pam16

Phylogenomic databases

eggNOGiKOG3442 Eukaryota
ENOG411286G LUCA
GeneTreeiENSGT00390000012037
HOGENOMiHOG000180095
HOVERGENiHBG094040
InParanoidiQ9CQV1
KOiK17805
OMAiYKYLMEA
OrthoDBiEOG091G0ZKM
PhylomeDBiQ9CQV1
TreeFamiTF315134

Miscellaneous databases

PROiPR:Q9CQV1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014301 Expressed in 21 organ(s), highest expression level in testis
ExpressionAtlasiQ9CQV1 baseline and differential
GenevisibleiQ9CQV1 MM

Family and domain databases

Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR036869 J_dom_sf
IPR005341 Tim16
PANTHERiPTHR12388 PTHR12388, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIM16_MOUSE
AccessioniPrimary (citable) accession number: Q9CQV1
Secondary accession number(s): Q6EIX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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