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Entry version 148 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Mitochondrial inner membrane protease subunit 1

Gene

Immp1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei40By similarity1
Active sitei83By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial inner membrane protease subunit 1 (EC:3.4.21.-)
Alternative name(s):
IMP1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Immp1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913791, Immp1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595741 – 166Mitochondrial inner membrane protease subunit 1Add BLAST166

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9CQU8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9CQU8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9CQU8

PeptideAtlas

More...
PeptideAtlasi
Q9CQU8

PRoteomics IDEntifications database

More...
PRIDEi
Q9CQU8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269478

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9CQU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042670, Expressed in zygote and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9CQU8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 subunits, IMMPL1 and IMMPL2.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000049044

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9CQU8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9CQU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S26 family. IMP1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0171, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028723_4_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9CQU8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKGPSME

Database of Orthologous Groups

More...
OrthoDBi
1211147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9CQU8

TreeFam database of animal gene trees

More...
TreeFami
TF315083

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06530, S26_SPase_I, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036286, LexA/Signal_pep-like_sf
IPR000223, Pept_S26A_signal_pept_1
IPR019533, Peptidase_S26

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10502, Peptidase_S26, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00727, LEADERPTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51306, SSF51306, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02227, sigpep_I_bact, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9CQU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGVLGKAF RLAGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI
60 70 80 90 100
VFAENLSRHF YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILSTSPSD
110 120 130 140 150
VFKSRSYVPT GHVWLEGDNL QNSTDSRYYG PIPYGLIRGR IFFKIWPFSD
160
FGFLRDSPNG QRFSDD
Length:166
Mass (Da):18,502
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5627EE1F1BD80E3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti94L → F in BAE40162 (PubMed:16141072).Curated1
Sequence conflicti166D → A in BAE40162 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK005356 mRNA Translation: BAB23971.1
AK009570 mRNA Translation: BAB26367.1
AK010075 mRNA Translation: BAB26684.1
AK011278 mRNA Translation: BAB27512.1
AK011382 mRNA Translation: BAB27582.1
AK011420 mRNA Translation: BAB27608.1
AK011466 mRNA Translation: BAB27637.1
AK011618 mRNA Translation: BAB27737.1
AK011872 mRNA Translation: BAB27891.1
AK012181 mRNA Translation: BAB28082.1
AK015978 mRNA Translation: BAB30062.1
AK078300 mRNA Translation: BAC37210.1
AK135670 mRNA Translation: BAE22608.1
AK168202 mRNA Translation: BAE40162.1
BC008259 mRNA Translation: AAH08259.1
BC081433 mRNA Translation: AAH81433.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38192.1

NCBI Reference Sequences

More...
RefSeqi
NP_082536.1, NM_028260.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037499; ENSMUSP00000049044; ENSMUSG00000042670

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66541

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66541

UCSC genome browser

More...
UCSCi
uc008lle.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005356 mRNA Translation: BAB23971.1
AK009570 mRNA Translation: BAB26367.1
AK010075 mRNA Translation: BAB26684.1
AK011278 mRNA Translation: BAB27512.1
AK011382 mRNA Translation: BAB27582.1
AK011420 mRNA Translation: BAB27608.1
AK011466 mRNA Translation: BAB27637.1
AK011618 mRNA Translation: BAB27737.1
AK011872 mRNA Translation: BAB27891.1
AK012181 mRNA Translation: BAB28082.1
AK015978 mRNA Translation: BAB30062.1
AK078300 mRNA Translation: BAC37210.1
AK135670 mRNA Translation: BAE22608.1
AK168202 mRNA Translation: BAE40162.1
BC008259 mRNA Translation: AAH08259.1
BC081433 mRNA Translation: AAH81433.1
CCDSiCCDS38192.1
RefSeqiNP_082536.1, NM_028260.2

3D structure databases

SMRiQ9CQU8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049044

PTM databases

PhosphoSitePlusiQ9CQU8

Proteomic databases

EPDiQ9CQU8
MaxQBiQ9CQU8
PaxDbiQ9CQU8
PeptideAtlasiQ9CQU8
PRIDEiQ9CQU8
ProteomicsDBi269478

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49000, 84 antibodies

The DNASU plasmid repository

More...
DNASUi
66541

Genome annotation databases

EnsembliENSMUST00000037499; ENSMUSP00000049044; ENSMUSG00000042670
GeneIDi66541
KEGGimmu:66541
UCSCiuc008lle.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196294
MGIiMGI:1913791, Immp1l

Phylogenomic databases

eggNOGiKOG0171, Eukaryota
GeneTreeiENSGT00550000075025
HOGENOMiCLU_028723_4_3_1
InParanoidiQ9CQU8
OMAiCKGPSME
OrthoDBi1211147at2759
PhylomeDBiQ9CQU8
TreeFamiTF315083

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
66541, 0 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Immp1l, mouse

Protein Ontology

More...
PROi
PR:Q9CQU8
RNActiQ9CQU8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042670, Expressed in zygote and 71 other tissues
GenevisibleiQ9CQU8, MM

Family and domain databases

CDDicd06530, S26_SPase_I, 1 hit
InterProiView protein in InterPro
IPR036286, LexA/Signal_pep-like_sf
IPR000223, Pept_S26A_signal_pept_1
IPR019533, Peptidase_S26
PfamiView protein in Pfam
PF10502, Peptidase_S26, 2 hits
PRINTSiPR00727, LEADERPTASE
SUPFAMiSSF51306, SSF51306, 1 hit
TIGRFAMsiTIGR02227, sigpep_I_bact, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMP1L_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9CQU8
Secondary accession number(s): Q3THN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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