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Protein

ZW10 interactor

Gene

Zwint

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
ZW10 interactor
Alternative name(s):
ZW10-interacting protein 1
Short name:
Zwint-1
Gene namesi
Name:Zwint
Synonyms:D10Ertd749e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1289227 Zwint

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665951 – 252ZW10 interactorAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineCombined sources1
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQU5
MaxQBiQ9CQU5
PaxDbiQ9CQU5
PeptideAtlasiQ9CQU5
PRIDEiQ9CQU5

PTM databases

iPTMnetiQ9CQU5
PhosphoSitePlusiQ9CQU5
SwissPalmiQ9CQU5

Expressioni

Gene expression databases

BgeeiENSMUSG00000019923 Expressed in 311 organ(s), highest expression level in inferior colliculus
CleanExiMM_ZWINT
ExpressionAtlasiQ9CQU5 baseline and differential
GenevisibleiQ9CQU5 MM

Interactioni

Subunit structurei

Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with KNL1, CETN3, DSN1 and PMF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206739, 19 interactors
IntActiQ9CQU5, 21 interactors
STRINGi10090.ENSMUSP00000020081

Structurei

3D structure databases

ProteinModelPortaliQ9CQU5
SMRiQ9CQU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 161Interaction with NDC80 and ZW10By similarityAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 221Sequence analysisAdd BLAST102

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ58 Eukaryota
ENOG4111831 LUCA
GeneTreeiENSGT00390000017639
HOGENOMiHOG000293254
HOVERGENiHBG079391
InParanoidiQ9CQU5
KOiK19943
OMAiERKTGTQ
OrthoDBiEOG091G0GKM
PhylomeDBiQ9CQU5
TreeFamiTF338101

Family and domain databases

InterProiView protein in InterPro
IPR029092 Zwint-1
PANTHERiPTHR31504 PTHR31504, 1 hit
PfamiView protein in Pfam
PF15556 Zwint, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAEKNAVA EKNNAVATKE VLAEAAAILE PVGLQEEAEL PAKIMEEFMR
60 70 80 90 100
NSRKKDKLLC SQLQVVNFLQ TFLAQEDTEQ SPDALASEDA SRQKATETKE
110 120 130 140 150
QWKDMKATYM DHVDVIKCAL SEALPQVKEA HRKYTELQKA FEQLEAKKRV
160 170 180 190 200
LEEKLQLAQK QWVLQQKRLQ NLTKISAEVK RRRKRALEKL DGSHQELETL
210 220 230 240 250
KQQAGQEQEK LQRNQSYLQL LCSLQNKLVI SEGKAEDKDV KGRALTAKSK

SP
Length:252
Mass (Da):28,713
Last modified:June 1, 2001 - v1
Checksum:i56CF28F7493CD4E8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7M1A0A1W2P7M1_MOUSE
ZW10 interactor
Zwint
126Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 7MADAEKN → PTRP in AAH13559 (PubMed:15489334).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004305 mRNA Translation: BAB23256.1
AK008144 mRNA Translation: BAB25492.1
AK013556 mRNA Translation: BAB28904.1
AK075977 mRNA Translation: BAC36090.1
AK134380 mRNA Translation: BAE22123.1
BC013559 mRNA Translation: AAH13559.1
BC027100 mRNA Translation: AAH27100.1
BC034870 mRNA Translation: AAH34870.1
CCDSiCCDS23920.1
RefSeqiNP_001280612.1, NM_001293683.1
NP_001280613.1, NM_001293684.1
NP_079911.1, NM_025635.4
UniGeneiMm.62876

Genome annotation databases

EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923
GeneIDi52696
KEGGimmu:52696
UCSCiuc007foy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004305 mRNA Translation: BAB23256.1
AK008144 mRNA Translation: BAB25492.1
AK013556 mRNA Translation: BAB28904.1
AK075977 mRNA Translation: BAC36090.1
AK134380 mRNA Translation: BAE22123.1
BC013559 mRNA Translation: AAH13559.1
BC027100 mRNA Translation: AAH27100.1
BC034870 mRNA Translation: AAH34870.1
CCDSiCCDS23920.1
RefSeqiNP_001280612.1, NM_001293683.1
NP_001280613.1, NM_001293684.1
NP_079911.1, NM_025635.4
UniGeneiMm.62876

3D structure databases

ProteinModelPortaliQ9CQU5
SMRiQ9CQU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206739, 19 interactors
IntActiQ9CQU5, 21 interactors
STRINGi10090.ENSMUSP00000020081

PTM databases

iPTMnetiQ9CQU5
PhosphoSitePlusiQ9CQU5
SwissPalmiQ9CQU5

Proteomic databases

EPDiQ9CQU5
MaxQBiQ9CQU5
PaxDbiQ9CQU5
PeptideAtlasiQ9CQU5
PRIDEiQ9CQU5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020081; ENSMUSP00000020081; ENSMUSG00000019923
ENSMUST00000105431; ENSMUSP00000101071; ENSMUSG00000019923
ENSMUST00000160337; ENSMUSP00000124429; ENSMUSG00000019923
GeneIDi52696
KEGGimmu:52696
UCSCiuc007foy.2 mouse

Organism-specific databases

CTDi11130
MGIiMGI:1289227 Zwint

Phylogenomic databases

eggNOGiENOG410IJ58 Eukaryota
ENOG4111831 LUCA
GeneTreeiENSGT00390000017639
HOGENOMiHOG000293254
HOVERGENiHBG079391
InParanoidiQ9CQU5
KOiK19943
OMAiERKTGTQ
OrthoDBiEOG091G0GKM
PhylomeDBiQ9CQU5
TreeFamiTF338101

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiZwint mouse
PROiPR:Q9CQU5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019923 Expressed in 311 organ(s), highest expression level in inferior colliculus
CleanExiMM_ZWINT
ExpressionAtlasiQ9CQU5 baseline and differential
GenevisibleiQ9CQU5 MM

Family and domain databases

InterProiView protein in InterPro
IPR029092 Zwint-1
PANTHERiPTHR31504 PTHR31504, 1 hit
PfamiView protein in Pfam
PF15556 Zwint, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZWINT_MOUSE
AccessioniPrimary (citable) accession number: Q9CQU5
Secondary accession number(s): Q3UYT8, Q91VI4, Q9D0W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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