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Protein

Thioredoxin domain-containing protein 12

Gene

Txndc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses significant protein thiol-disulfide oxidase activity.By similarity

Catalytic activityi

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
Alternative name(s):
Endoplasmic reticulum resident protein 19
Short name:
ER protein 19
Short name:
ERp19
Thioredoxin-like protein p19
Gene namesi
Name:Txndc12
Synonyms:Tlp19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913323 Txndc12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000003419025 – 170Thioredoxin domain-containing protein 12Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9CQU0
MaxQBiQ9CQU0
PaxDbiQ9CQU0
PeptideAtlasiQ9CQU0
PRIDEiQ9CQU0

2D gel databases

REPRODUCTION-2DPAGEiQ9CQU0

PTM databases

PhosphoSitePlusiQ9CQU0
SwissPalmiQ9CQU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000028567 Expressed in 283 organ(s), highest expression level in placenta
GenevisibleiQ9CQU0 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CQU0, 6 interactors
MINTiQ9CQU0
STRINGi10090.ENSMUSP00000030296

Structurei

3D structure databases

ProteinModelPortaliQ9CQU0
SMRiQ9CQU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi167 – 170Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG410IWGE Eukaryota
ENOG4111X7E LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG107174
InParanoidiQ9CQU0
KOiK05360
OMAiNIHWRTL
OrthoDBiEOG091G0RHV
PhylomeDBiQ9CQU0
TreeFamiTF321449

Family and domain databases

CDDicd02959 ERp19, 1 hit
InterProiView protein in InterPro
IPR037462 ERp19
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRFGATCL LSFSFLLLIT SSDGRTGLGK GFGDHIHWRT LEDGKKEAAA
60 70 80 90 100
SGLPLMVIIH KSWCGACKAL KPKFAESTEI SELSHNFVMV NLEDEEEPRD
110 120 130 140 150
EDFSPDGGYI PRILFLDPSG KVRPEIINES GNPSYKYFYV SAEQVVQGMK
160 170
EAQERLTGDA FREKHFQDEL
Length:170
Mass (Da):19,049
Last modified:June 1, 2001 - v1
Checksum:i5B91FC9BE12C5E44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548113 mRNA Translation: AAS55653.1
AK003481 mRNA Translation: BAB22811.1
AK002862 mRNA Translation: BAB22413.1
BC006857 mRNA Translation: AAH06857.1
CCDSiCCDS18457.1
RefSeqiNP_079610.1, NM_025334.3
UniGeneiMm.159965

Genome annotation databases

EnsembliENSMUST00000030296; ENSMUSP00000030296; ENSMUSG00000028567
GeneIDi66073
KEGGimmu:66073
UCSCiuc008ubs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY548113 mRNA Translation: AAS55653.1
AK003481 mRNA Translation: BAB22811.1
AK002862 mRNA Translation: BAB22413.1
BC006857 mRNA Translation: AAH06857.1
CCDSiCCDS18457.1
RefSeqiNP_079610.1, NM_025334.3
UniGeneiMm.159965

3D structure databases

ProteinModelPortaliQ9CQU0
SMRiQ9CQU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQU0, 6 interactors
MINTiQ9CQU0
STRINGi10090.ENSMUSP00000030296

PTM databases

PhosphoSitePlusiQ9CQU0
SwissPalmiQ9CQU0

2D gel databases

REPRODUCTION-2DPAGEiQ9CQU0

Proteomic databases

EPDiQ9CQU0
MaxQBiQ9CQU0
PaxDbiQ9CQU0
PeptideAtlasiQ9CQU0
PRIDEiQ9CQU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030296; ENSMUSP00000030296; ENSMUSG00000028567
GeneIDi66073
KEGGimmu:66073
UCSCiuc008ubs.1 mouse

Organism-specific databases

CTDi51060
MGIiMGI:1913323 Txndc12

Phylogenomic databases

eggNOGiENOG410IWGE Eukaryota
ENOG4111X7E LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG107174
InParanoidiQ9CQU0
KOiK05360
OMAiNIHWRTL
OrthoDBiEOG091G0RHV
PhylomeDBiQ9CQU0
TreeFamiTF321449

Miscellaneous databases

ChiTaRSiTxndc12 mouse
PROiPR:Q9CQU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028567 Expressed in 283 organ(s), highest expression level in placenta
GenevisibleiQ9CQU0 MM

Family and domain databases

CDDicd02959 ERp19, 1 hit
InterProiView protein in InterPro
IPR037462 ERp19
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXD12_MOUSE
AccessioniPrimary (citable) accession number: Q9CQU0
Secondary accession number(s): Q53YN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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