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Protein

Proteasome maturation protein

Gene

Pomp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome maturation protein
Alternative name(s):
Proteassemblin
Protein UMP1 homolog
Short name:
mUMP1
Gene namesi
Name:Pomp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913787 Pomp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471851 – 141Proteasome maturation proteinAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9CQT5
MaxQBiQ9CQT5
PaxDbiQ9CQT5
PeptideAtlasiQ9CQT5
PRIDEiQ9CQT5

PTM databases

iPTMnetiQ9CQT5
PhosphoSitePlusiQ9CQT5

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By interferon gamma.1 Publication

Gene expression databases

BgeeiENSMUSG00000029649 Expressed in 297 organ(s), highest expression level in pharyngeal arch 1
CleanExiMM_POMP
ExpressionAtlasiQ9CQT5 baseline and differential
GenevisibleiQ9CQT5 MM

Interactioni

Subunit structurei

Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i is controversial. Forms tetramers (By similarity).By similarity

Protein-protein interaction databases

BioGridi211543, 1 interactor
STRINGi10090.ENSMUSP00000031654

Family & Domainsi

Sequence similaritiesi

Belongs to the POMP/UMP1 family.Curated

Phylogenomic databases

eggNOGiKOG3061 Eukaryota
ENOG410XUI5 LUCA
GeneTreeiENSGT00390000010734
HOGENOMiHOG000276894
HOVERGENiHBG057292
InParanoidiQ9CQT5
KOiK11599
OMAiHDTLRYG
OrthoDBiEOG091G0V3C
PhylomeDBiQ9CQT5
TreeFamiTF323548

Family and domain databases

InterProiView protein in InterPro
IPR008012 Ump1
PANTHERiPTHR12828 PTHR12828, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNARGLGSEL KDSIPVAELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL
60 70 80 90 100
SEKNFQLNQD KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVH RLPFLPSSNL
110 120 130 140
SLDILRGNDE TIGFEDILND PSQSELMGEP HVMVEHKLGL L
Length:141
Mass (Da):15,766
Last modified:June 1, 2001 - v1
Checksum:i5CDA8C2EB7E2D7DF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUI3A0A0J9YUI3_MOUSE
Proteasome maturation protein
Pomp
119Annotation score:
A0A0J9YVJ2A0A0J9YVJ2_MOUSE
Proteasome maturation protein
Pomp
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52E → K in BAB29067 (PubMed:16141072).Curated1
Sequence conflicti126L → Q in BAB28250 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003439 mRNA Translation: BAB22791.1
AK011115 mRNA Translation: BAB27410.1
AK012455 mRNA Translation: BAB28250.1
AK013934 mRNA Translation: BAB29067.1
AK014296 mRNA Translation: BAB29252.1
AK167958 mRNA Translation: BAE39956.1
BC027016 mRNA Translation: AAH27016.1
CCDSiCCDS39402.1
RefSeqiNP_079900.1, NM_025624.2
UniGeneiMm.332855

Genome annotation databases

EnsembliENSMUST00000031654; ENSMUSP00000031654; ENSMUSG00000029649
GeneIDi66537
KEGGimmu:66537
UCSCiuc009aoj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003439 mRNA Translation: BAB22791.1
AK011115 mRNA Translation: BAB27410.1
AK012455 mRNA Translation: BAB28250.1
AK013934 mRNA Translation: BAB29067.1
AK014296 mRNA Translation: BAB29252.1
AK167958 mRNA Translation: BAE39956.1
BC027016 mRNA Translation: AAH27016.1
CCDSiCCDS39402.1
RefSeqiNP_079900.1, NM_025624.2
UniGeneiMm.332855

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211543, 1 interactor
STRINGi10090.ENSMUSP00000031654

PTM databases

iPTMnetiQ9CQT5
PhosphoSitePlusiQ9CQT5

Proteomic databases

EPDiQ9CQT5
MaxQBiQ9CQT5
PaxDbiQ9CQT5
PeptideAtlasiQ9CQT5
PRIDEiQ9CQT5

Protocols and materials databases

DNASUi66537
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031654; ENSMUSP00000031654; ENSMUSG00000029649
GeneIDi66537
KEGGimmu:66537
UCSCiuc009aoj.1 mouse

Organism-specific databases

CTDi51371
MGIiMGI:1913787 Pomp

Phylogenomic databases

eggNOGiKOG3061 Eukaryota
ENOG410XUI5 LUCA
GeneTreeiENSGT00390000010734
HOGENOMiHOG000276894
HOVERGENiHBG057292
InParanoidiQ9CQT5
KOiK11599
OMAiHDTLRYG
OrthoDBiEOG091G0V3C
PhylomeDBiQ9CQT5
TreeFamiTF323548

Miscellaneous databases

ChiTaRSiPomp mouse
PROiPR:Q9CQT5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029649 Expressed in 297 organ(s), highest expression level in pharyngeal arch 1
CleanExiMM_POMP
ExpressionAtlasiQ9CQT5 baseline and differential
GenevisibleiQ9CQT5 MM

Family and domain databases

InterProiView protein in InterPro
IPR008012 Ump1
PANTHERiPTHR12828 PTHR12828, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOMP_MOUSE
AccessioniPrimary (citable) accession number: Q9CQT5
Secondary accession number(s): Q9CXV8, Q9CZL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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