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Protein

RNA-binding protein 7

Gene

Rbm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Possible involved in germ cell RNA processing and meiosis.By similarity

GO - Molecular functioni

  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 7
Alternative name(s):
RNA-binding motif protein 7
Gene namesi
Name:Rbm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914260 Rbm7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000817622 – 265RNA-binding protein 7Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei152Omega-N-methylarginineBy similarity1
Modified residuei203PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CQT2
MaxQBiQ9CQT2
PaxDbiQ9CQT2
PRIDEiQ9CQT2

PTM databases

iPTMnetiQ9CQT2
PhosphoSitePlusiQ9CQT2

Expressioni

Gene expression databases

BgeeiENSMUSG00000042396 Expressed in 274 organ(s), highest expression level in humerus cartilage element
CleanExiMM_RBM7
ExpressionAtlasiQ9CQT2 baseline and differential
GenevisibleiQ9CQT2 MM

Interactioni

Subunit structurei

Component of the nuclear exosome targeting (NEXT) complex composed of MTREX, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation. Interacts with ZCCHC8 and SF3B2/SAP145. Binds to MTREX.By similarity

Protein-protein interaction databases

IntActiQ9CQT2, 2 interactors
MINTiQ9CQT2
STRINGi10090.ENSMUSP00000126374

Structurei

3D structure databases

ProteinModelPortaliQ9CQT2
SMRiQ9CQT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 35ZCCHC8 bindingBy similarityAdd BLAST11
Regioni59 – 76ZCCHC8 bindingBy similarityAdd BLAST18

Phylogenomic databases

eggNOGiKOG4454 Eukaryota
ENOG41123B7 LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000059553
HOVERGENiHBG009324
InParanoidiQ9CQT2
KOiK13188
OMAiDHHYRGN
OrthoDBiEOG091G15TA
PhylomeDBiQ9CQT2
TreeFamiTF323596

Family and domain databases

CDDicd12592 RRM_RBM7, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034500 RBM7_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKLK
60 70 80 90 100
QFAFVNFKHE VSVPYAMNLL NGIKLFGRPI KIQFRSGSSH ASQDASVSYP
110 120 130 140 150
QHHVGNLSPT STSPNSYERT VGNVSPTAQM VQRSFSSPED YQRQAVMNSV
160 170 180 190 200
FRQMSYAGKF GSPHADQLGF SPSAQPHGHT FNQSSSSQWR QDALSSQRKR
210 220 230 240 250
QNSHPYLADR HYSREQRYSD HGSDYHYRGS REDFYYDDRN HDGWSHDYDN
260
RRDSSRGGKW PSSRH
Length:265
Mass (Da):30,148
Last modified:June 1, 2001 - v1
Checksum:i5D99650FD1FBF0C8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SRC3A0A1L1SRC3_MOUSE
RNA-binding protein 7
Rbm7
158Annotation score:
A0A1L1SUJ3A0A1L1SUJ3_MOUSE
RNA-binding protein 7
Rbm7
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240N → D in AAH54774 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458961 mRNA Translation: AAL60585.1
AK005200 mRNA Translation: BAB23878.1
AK006755 mRNA Translation: BAB24729.1
AK008645 mRNA Translation: BAB25804.1
AK151056 mRNA Translation: BAE30073.1
BC054774 mRNA Translation: AAH54774.1
CCDSiCCDS23155.1
RefSeqiNP_659197.2, NM_144948.5
UniGeneiMm.76911

Genome annotation databases

EnsembliENSMUST00000170000; ENSMUSP00000126374; ENSMUSG00000042396
GeneIDi67010
KEGGimmu:67010
UCSCiuc009pic.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458961 mRNA Translation: AAL60585.1
AK005200 mRNA Translation: BAB23878.1
AK006755 mRNA Translation: BAB24729.1
AK008645 mRNA Translation: BAB25804.1
AK151056 mRNA Translation: BAE30073.1
BC054774 mRNA Translation: AAH54774.1
CCDSiCCDS23155.1
RefSeqiNP_659197.2, NM_144948.5
UniGeneiMm.76911

3D structure databases

ProteinModelPortaliQ9CQT2
SMRiQ9CQT2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQT2, 2 interactors
MINTiQ9CQT2
STRINGi10090.ENSMUSP00000126374

PTM databases

iPTMnetiQ9CQT2
PhosphoSitePlusiQ9CQT2

Proteomic databases

EPDiQ9CQT2
MaxQBiQ9CQT2
PaxDbiQ9CQT2
PRIDEiQ9CQT2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170000; ENSMUSP00000126374; ENSMUSG00000042396
GeneIDi67010
KEGGimmu:67010
UCSCiuc009pic.2 mouse

Organism-specific databases

CTDi10179
MGIiMGI:1914260 Rbm7

Phylogenomic databases

eggNOGiKOG4454 Eukaryota
ENOG41123B7 LUCA
GeneTreeiENSGT00870000136493
HOGENOMiHOG000059553
HOVERGENiHBG009324
InParanoidiQ9CQT2
KOiK13188
OMAiDHHYRGN
OrthoDBiEOG091G15TA
PhylomeDBiQ9CQT2
TreeFamiTF323596

Miscellaneous databases

PROiPR:Q9CQT2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042396 Expressed in 274 organ(s), highest expression level in humerus cartilage element
CleanExiMM_RBM7
ExpressionAtlasiQ9CQT2 baseline and differential
GenevisibleiQ9CQT2 MM

Family and domain databases

CDDicd12592 RRM_RBM7, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034500 RBM7_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM7_MOUSE
AccessioniPrimary (citable) accession number: Q9CQT2
Secondary accession number(s): Q3UB91, Q7TQE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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