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Protein

Protein transport protein Sec61 subunit beta

Gene

Sec61b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157).By similarity1 Publication

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • epidermal growth factor binding Source: MGI
  • ribosome binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:Sec61b1 PublicationImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913462 Sec61b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001572552 – 96Protein transport protein Sec61 subunit betaAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Lipidationi39S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9CQS8
MaxQBiQ9CQS8
PaxDbiQ9CQS8
PeptideAtlasiQ9CQS8
PRIDEiQ9CQS8
TopDownProteomicsiQ9CQS8

PTM databases

iPTMnetiQ9CQS8
PhosphoSitePlusiQ9CQS8
SwissPalmiQ9CQS8

Expressioni

Gene expression databases

BgeeiENSMUSG00000053317 Expressed in 70 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SEC61B
ExpressionAtlasiQ9CQS8 baseline and differential
GenevisibleiQ9CQS8 MM

Interactioni

Subunit structurei

The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211302, 3 interactors
CORUMiQ9CQS8
IntActiQ9CQS8, 2 interactors
STRINGi10090.ENSMUSP00000067681

Structurei

3D structure databases

ProteinModelPortaliQ9CQS8
SMRiQ9CQS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457 Eukaryota
ENOG4111UAR LUCA
GeneTreeiENSGT00390000003561
HOGENOMiHOG000211109
HOVERGENiHBG061281
InParanoidiQ9CQS8
KOiK09481
OMAiNSGGMWR
PhylomeDBiQ9CQS8
TreeFamiTF313144

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IAAVFMLHIW GKYTRS
Length:96
Mass (Da):9,958
Last modified:January 23, 2007 - v3
Checksum:i5FAFF4197A742049
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5P9A8Y5P9_MOUSE
Protein transport protein Sec61 sub...
Sec61b
117Annotation score:
A8Y5P8A8Y5P8_MOUSE
Protein transport protein Sec61 sub...
Sec61b
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004505 mRNA Translation: BAB23338.1
AK008739 mRNA Translation: BAB25868.1
BC002089 mRNA Translation: AAH02089.1
BC081445 mRNA Translation: AAH81445.1
CCDSiCCDS38759.1
RefSeqiNP_077133.1, NM_024171.2
UniGeneiMm.20188

Genome annotation databases

EnsembliENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317
GeneIDi66212
KEGGimmu:66212
UCSCiuc008sur.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004505 mRNA Translation: BAB23338.1
AK008739 mRNA Translation: BAB25868.1
BC002089 mRNA Translation: AAH02089.1
BC081445 mRNA Translation: AAH81445.1
CCDSiCCDS38759.1
RefSeqiNP_077133.1, NM_024171.2
UniGeneiMm.20188

3D structure databases

ProteinModelPortaliQ9CQS8
SMRiQ9CQS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211302, 3 interactors
CORUMiQ9CQS8
IntActiQ9CQS8, 2 interactors
STRINGi10090.ENSMUSP00000067681

PTM databases

iPTMnetiQ9CQS8
PhosphoSitePlusiQ9CQS8
SwissPalmiQ9CQS8

Proteomic databases

EPDiQ9CQS8
MaxQBiQ9CQS8
PaxDbiQ9CQS8
PeptideAtlasiQ9CQS8
PRIDEiQ9CQS8
TopDownProteomicsiQ9CQS8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317
GeneIDi66212
KEGGimmu:66212
UCSCiuc008sur.1 mouse

Organism-specific databases

CTDi10952
MGIiMGI:1913462 Sec61b

Phylogenomic databases

eggNOGiKOG3457 Eukaryota
ENOG4111UAR LUCA
GeneTreeiENSGT00390000003561
HOGENOMiHOG000211109
HOVERGENiHBG061281
InParanoidiQ9CQS8
KOiK09481
OMAiNSGGMWR
PhylomeDBiQ9CQS8
TreeFamiTF313144

Enzyme and pathway databases

ReactomeiR-MMU-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSec61b mouse
PROiPR:Q9CQS8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053317 Expressed in 70 organ(s), highest expression level in dorsal pancreas
CleanExiMM_SEC61B
ExpressionAtlasiQ9CQS8 baseline and differential
GenevisibleiQ9CQS8 MM

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC61B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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