UniProtKB - Q9CQS8 (SC61B_MOUSE)
Protein
Protein transport protein Sec61 subunit beta
Gene
Sec61b
Organism
Mus musculus (Mouse)
Status
Functioni
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157).By similarity1 Publication
GO - Molecular functioni
- ARF guanyl-nucleotide exchange factor activity Source: GO_Central
- epidermal growth factor binding Source: MGI
- ribosome binding Source: MGI
GO - Biological processi
- posttranslational protein targeting to membrane, translocation Source: GO_Central
- retrograde protein transport, ER to cytosol Source: MGI
- SRP-dependent cotranslational protein targeting to membrane, translocation Source: GO_Central
- ubiquitin-dependent ERAD pathway Source: MGI
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein Sec61 subunit beta |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913462, Sec61b |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB
- endoplasmic reticulum quality control compartment Source: UniProtKB
- endoplasmic reticulum Sec complex Source: GO_Central
- Sec61 translocon complex Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 70 | CytoplasmicSequence analysisAdd BLAST | 69 | |
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000157255 | 2 – 96 | Protein transport protein Sec61 subunit betaAdd BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylprolineBy similarity | 1 | |
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 9 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 14 | PhosphoserineBy similarity | 1 | |
Modified residuei | 17 | PhosphoserineBy similarity | 1 | |
Lipidationi | 39 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q9CQS8 |
jPOSTi | Q9CQS8 |
MaxQBi | Q9CQS8 |
PaxDbi | Q9CQS8 |
PeptideAtlasi | Q9CQS8 |
PRIDEi | Q9CQS8 |
TopDownProteomicsi | Q9CQS8 |
PTM databases
iPTMneti | Q9CQS8 |
PhosphoSitePlusi | Q9CQS8 |
SwissPalmi | Q9CQS8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053317, Expressed in pancreas and 100 other tissues |
ExpressionAtlasi | Q9CQS8, baseline and differential |
Genevisiblei | Q9CQS8, MM |
Interactioni
Subunit structurei
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
By similarityGO - Molecular functioni
- ARF guanyl-nucleotide exchange factor activity Source: GO_Central
- epidermal growth factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 211302, 5 interactors |
CORUMi | Q9CQS8 |
IntActi | Q9CQS8, 2 interactors |
STRINGi | 10090.ENSMUSP00000067681 |
Miscellaneous databases
RNActi | Q9CQS8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SEC61-beta family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3457, Eukaryota |
GeneTreei | ENSGT00390000003561 |
HOGENOMi | CLU_133423_4_0_1 |
InParanoidi | Q9CQS8 |
OMAi | WGKYTRG |
OrthoDBi | 1634609at2759 |
PhylomeDBi | Q9CQS8 |
TreeFami | TF313144 |
Family and domain databases
InterProi | View protein in InterPro IPR030671, Sec61-beta/Sbh IPR016482, SecG/Sec61-beta/Sbh |
PANTHERi | PTHR13509, PTHR13509, 1 hit |
Pfami | View protein in Pfam PF03911, Sec61_beta, 1 hit |
PIRSFi | PIRSF006398, Sec61_beta_euk, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9CQS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IAAVFMLHIW GKYTRS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8Y5P8 | A8Y5P8_MOUSE | Protein transport protein Sec61 sub... | Sec61b | 140 | Annotation score: | ||
A8Y5P9 | A8Y5P9_MOUSE | Protein transport protein Sec61 sub... | Sec61b | 117 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004505 mRNA Translation: BAB23338.1 AK008739 mRNA Translation: BAB25868.1 BC002089 mRNA Translation: AAH02089.1 BC081445 mRNA Translation: AAH81445.1 |
CCDSi | CCDS38759.1 |
RefSeqi | NP_077133.1, NM_024171.2 |
Genome annotation databases
Ensembli | ENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317 |
GeneIDi | 66212 |
KEGGi | mmu:66212 |
UCSCi | uc008sur.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004505 mRNA Translation: BAB23338.1 AK008739 mRNA Translation: BAB25868.1 BC002089 mRNA Translation: AAH02089.1 BC081445 mRNA Translation: AAH81445.1 |
CCDSi | CCDS38759.1 |
RefSeqi | NP_077133.1, NM_024171.2 |
3D structure databases
SMRi | Q9CQS8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211302, 5 interactors |
CORUMi | Q9CQS8 |
IntActi | Q9CQS8, 2 interactors |
STRINGi | 10090.ENSMUSP00000067681 |
PTM databases
iPTMneti | Q9CQS8 |
PhosphoSitePlusi | Q9CQS8 |
SwissPalmi | Q9CQS8 |
Proteomic databases
EPDi | Q9CQS8 |
jPOSTi | Q9CQS8 |
MaxQBi | Q9CQS8 |
PaxDbi | Q9CQS8 |
PeptideAtlasi | Q9CQS8 |
PRIDEi | Q9CQS8 |
TopDownProteomicsi | Q9CQS8 |
Genome annotation databases
Ensembli | ENSMUST00000065678; ENSMUSP00000067681; ENSMUSG00000053317 |
GeneIDi | 66212 |
KEGGi | mmu:66212 |
UCSCi | uc008sur.1, mouse |
Organism-specific databases
CTDi | 10952 |
MGIi | MGI:1913462, Sec61b |
Phylogenomic databases
eggNOGi | KOG3457, Eukaryota |
GeneTreei | ENSGT00390000003561 |
HOGENOMi | CLU_133423_4_0_1 |
InParanoidi | Q9CQS8 |
OMAi | WGKYTRG |
OrthoDBi | 1634609at2759 |
PhylomeDBi | Q9CQS8 |
TreeFami | TF313144 |
Miscellaneous databases
BioGRID-ORCSi | 66212, 6 hits in 18 CRISPR screens |
ChiTaRSi | Sec61b, mouse |
PROi | PR:Q9CQS8 |
RNActi | Q9CQS8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053317, Expressed in pancreas and 100 other tissues |
ExpressionAtlasi | Q9CQS8, baseline and differential |
Genevisiblei | Q9CQS8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR030671, Sec61-beta/Sbh IPR016482, SecG/Sec61-beta/Sbh |
PANTHERi | PTHR13509, PTHR13509, 1 hit |
Pfami | View protein in Pfam PF03911, Sec61_beta, 1 hit |
PIRSFi | PIRSF006398, Sec61_beta_euk, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC61B_MOUSE | |
Accessioni | Q9CQS8Primary (citable) accession number: Q9CQS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families