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Protein

Solute carrier family 25 member 46

Gene

Slc25a46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914703 Slc25a46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 123Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei167 – 187Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei202 – 222Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei314 – 334Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei382 – 402Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918291 – 418Solute carrier family 25 member 46Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei35PhosphoserineBy similarity1
Modified residuei45PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQS4
PaxDbiQ9CQS4
PeptideAtlasiQ9CQS4
PRIDEiQ9CQS4

PTM databases

iPTMnetiQ9CQS4
PhosphoSitePlusiQ9CQS4

Expressioni

Gene expression databases

BgeeiENSMUSG00000024259
CleanExiMM_SLC25A46
GenevisibleiQ9CQS4 MM

Interactioni

Subunit structurei

Interacts with IMMT.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053325

Structurei

3D structure databases

ProteinModelPortaliQ9CQS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 187Solcar 1Add BLAST92
Repeati311 – 413Solcar 2Add BLAST103

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954 Eukaryota
ENOG410XRFB LUCA
GeneTreeiENSGT00390000015874
HOGENOMiHOG000007981
HOVERGENiHBG059752
InParanoidiQ9CQS4
KOiK03454
OMAiEISHKWN
OrthoDBiEOG091G05RA
PhylomeDBiQ9CQS4
TreeFamiTF313365

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
IPR039158 SLC25A46
PANTHERiPTHR21252 PTHR21252, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 1 hit
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

Q9CQS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRRPEGFD GLGYRGGVRD DPAFGGPFHA RSFGSGTELG HWVTTPPDIP
60 70 80 90 100
GSRNLHWGEK SPSYGVPSAP PTLEGSAEEP FPGGGEGPRP GPSSEQLNRF
110 120 130 140 150
AGFGIGLASL FTENVLAHPC IVLRRQCQVN YHARHYHLTP FSIINIMYSF
160 170 180 190 200
NKTQGPRALW KGMGSTFIVQ GVTLGAEGII SEFTPLPREV SHKLNPKQIG
210 220 230 240 250
EHLLLKCLTY MVAMPFYSAS LIETVQSEII RDNTGILECV KEGIGRVIGL
260 270 280 290 300
GVPHSKRLLP LFSLIFPTVL HGVLHYIISS IIQKIVLLIL KRKTYNSHLA
310 320 330 340 350
ESTSPMQNML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII
360 370 380 390 400
DNTDLGYEVL PINTQYEGMR DCINTIKQEE GVFGFYKGFG AVIIQYTLHA
410
TILQITKMIY STLLQNSI
Length:418
Mass (Da):46,224
Last modified:June 1, 2001 - v1
Checksum:i621A9892D62C6CD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → G in BAE28241 (PubMed:16141072).Curated1
Sequence conflicti59E → G in BAE36038 (PubMed:16141072).Curated1
Sequence conflicti85G → S in AAH20087 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004625 mRNA Translation: BAB23420.1
AK008131 mRNA Translation: BAB25481.1
AK030346 mRNA Translation: BAC26914.1
AK031117 mRNA Translation: BAC27260.1
AK147936 mRNA Translation: BAE28241.1
AK160834 mRNA Translation: BAE36038.1
BC020087 mRNA Translation: AAH20087.1
CCDSiCCDS29110.1
RefSeqiNP_080441.1, NM_026165.3
UniGeneiMm.23896

Genome annotation databases

EnsembliENSMUST00000060396; ENSMUSP00000053325; ENSMUSG00000024259
GeneIDi67453
KEGGimmu:67453
UCSCiuc008ehz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS2546_MOUSE
AccessioniPrimary (citable) accession number: Q9CQS4
Secondary accession number(s): Q3TUD3, Q3UGG7, Q8VDX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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