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Protein

U6 snRNA-associated Sm-like protein LSm7

Gene

Lsm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm7
Gene namesi
Name:Lsm7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913344 Lsm7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001255802 – 103U6 snRNA-associated Sm-like protein LSm7Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQQ8
MaxQBiQ9CQQ8
PaxDbiQ9CQQ8
PeptideAtlasiQ9CQQ8
PRIDEiQ9CQQ8

2D gel databases

REPRODUCTION-2DPAGEiQ9CQQ8

PTM databases

iPTMnetiQ9CQQ8
PhosphoSitePlusiQ9CQQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000035215 Expressed in 33 organ(s), highest expression level in olfactory epithelium
ExpressionAtlasiQ9CQQ8 baseline and differential

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Interacts with TACC1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQQ8, 3 interactors
MINTiQ9CQQ8
STRINGi10090.ENSMUSP00000072521

Structurei

3D structure databases

ProteinModelPortaliQ9CQQ8
SMRiQ9CQQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1781 Eukaryota
ENOG4111VMJ LUCA
GeneTreeiENSGT00510000047872
HOGENOMiHOG000223548
HOVERGENiHBG000513
InParanoidiQ9CQQ8
KOiK12626
OMAiGPKREAI
OrthoDBiEOG091G14J2
PhylomeDBiQ9CQQ8
TreeFamiTF314385

Family and domain databases

CDDicd01729 LSm7, 1 hit
InterProiView protein in InterPro
IPR017132 Lsm7
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG
60 70 80 90 100
TMEYMRDPDD QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFVQQ

QDT
Length:103
Mass (Da):11,636
Last modified:June 1, 2001 - v1
Checksum:i6859DC08A81AE808
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6N1A0A1W2P6N1_MOUSE
MCG12127, isoform CRA_e
Lsm7 mCG_12127
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013355 mRNA Translation: BAB28806.1
BC027511 mRNA Translation: AAH27511.1
BC081444 mRNA Translation: AAH81444.1
AK003062 mRNA Translation: BAB22540.1
AK007462 mRNA Translation: BAB25051.1
AK012446 mRNA Translation: BAB28245.1
CCDSiCCDS35987.1
RefSeqiNP_079625.1, NM_025349.2
UniGeneiMm.379101

Genome annotation databases

EnsembliENSMUST00000035775; ENSMUSP00000044993; ENSMUSG00000035215
GeneIDi66094
KEGGimmu:66094
UCSCiuc007gez.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013355 mRNA Translation: BAB28806.1
BC027511 mRNA Translation: AAH27511.1
BC081444 mRNA Translation: AAH81444.1
AK003062 mRNA Translation: BAB22540.1
AK007462 mRNA Translation: BAB25051.1
AK012446 mRNA Translation: BAB28245.1
CCDSiCCDS35987.1
RefSeqiNP_079625.1, NM_025349.2
UniGeneiMm.379101

3D structure databases

ProteinModelPortaliQ9CQQ8
SMRiQ9CQQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQQ8, 3 interactors
MINTiQ9CQQ8
STRINGi10090.ENSMUSP00000072521

PTM databases

iPTMnetiQ9CQQ8
PhosphoSitePlusiQ9CQQ8

2D gel databases

REPRODUCTION-2DPAGEiQ9CQQ8

Proteomic databases

EPDiQ9CQQ8
MaxQBiQ9CQQ8
PaxDbiQ9CQQ8
PeptideAtlasiQ9CQQ8
PRIDEiQ9CQQ8

Protocols and materials databases

DNASUi66094
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035775; ENSMUSP00000044993; ENSMUSG00000035215
GeneIDi66094
KEGGimmu:66094
UCSCiuc007gez.1 mouse

Organism-specific databases

CTDi51690
MGIiMGI:1913344 Lsm7

Phylogenomic databases

eggNOGiKOG1781 Eukaryota
ENOG4111VMJ LUCA
GeneTreeiENSGT00510000047872
HOGENOMiHOG000223548
HOVERGENiHBG000513
InParanoidiQ9CQQ8
KOiK12626
OMAiGPKREAI
OrthoDBiEOG091G14J2
PhylomeDBiQ9CQQ8
TreeFamiTF314385

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q9CQQ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035215 Expressed in 33 organ(s), highest expression level in olfactory epithelium
ExpressionAtlasiQ9CQQ8 baseline and differential

Family and domain databases

CDDicd01729 LSm7, 1 hit
InterProiView protein in InterPro
IPR017132 Lsm7
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM7_MOUSE
AccessioniPrimary (citable) accession number: Q9CQQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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