UniProtKB - Q9CQN1 (TRAP1_MOUSE)
Protein
Heat shock protein 75 kDa, mitochondrial
Gene
Trap1
Organism
Mus musculus (Mouse)
Status
Functioni
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 121 | ATPBy similarity | 1 | |
Binding sitei | 160 | ATPBy similarity | 1 | |
Binding sitei | 173 | ATPBy similarity | 1 | |
Binding sitei | 207 | ATP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 404 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase binding Source: ParkinsonsUK-UCL
- RNA binding Source: ParkinsonsUK-UCL
- unfolded protein binding Source: GO_Central
GO - Biological processi
- negative regulation of cellular respiration Source: UniProtKB
- negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source: ParkinsonsUK-UCL
- protein folding Source: GO_Central
- translational attenuation Source: MGI
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein 75 kDa, mitochondrialShort name: HSP 75 Alternative name(s): TNFR-associated protein 1 Tumor necrosis factor type 1 receptor-associated protein Short name: TRAP-1 |
Gene namesi | Name:Trap1 Synonyms:Hsp75 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915265, Trap1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
- Mitochondrion inner membrane By similarity
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial intermembrane space Source: ParkinsonsUK-UCL
- mitochondrial matrix Source: UniProtKB
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 60 | MitochondrionBy similarityAdd BLAST | 60 | |
ChainiPRO_0000013605 | 61 – 706 | Heat shock protein 75 kDa, mitochondrialAdd BLAST | 646 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 176 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 326 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 334 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 426 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 433 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 468 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 496 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 570 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9CQN1 |
jPOSTi | Q9CQN1 |
MaxQBi | Q9CQN1 |
PaxDbi | Q9CQN1 |
PeptideAtlasi | Q9CQN1 |
PRIDEi | Q9CQN1 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9CQN1 |
PTM databases
iPTMneti | Q9CQN1 |
PhosphoSitePlusi | Q9CQN1 |
SwissPalmi | Q9CQN1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000005981, Expressed in cortex of kidney and 288 other tissues |
ExpressionAtlasi | Q9CQN1, baseline and differential |
Genevisiblei | Q9CQN1, MM |
Interactioni
Subunit structurei
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1.
Interacts with SRC.
Interacts with SDHA.
By similarityGO - Molecular functioni
- protein kinase binding Source: ParkinsonsUK-UCL
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 212597, 19 interactors |
IntActi | Q9CQN1, 5 interactors |
MINTi | Q9CQN1 |
STRINGi | 10090.ENSMUSP00000006137 |
Miscellaneous databases
RNActi | Q9CQN1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 90 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0019, Eukaryota |
GeneTreei | ENSGT00950000182747 |
HOGENOMi | CLU_006684_3_1_1 |
InParanoidi | Q9CQN1 |
OMAi | VITVEEM |
OrthoDBi | 924636at2759 |
PhylomeDBi | Q9CQN1 |
TreeFami | TF315234 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9CQN1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACELRAVLL WGRGLQTVLR APALAGVRRG KPVLHLQKTT VQFRGPTQSL
60 70 80 90 100
ASGISAGQLY STQAAEDKEE ESLHSIISNT EAVRGSVSKH EFQAETKKLL
110 120 130 140 150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKLVCEGQVL PEMEIHLQTD
160 170 180 190 200
AKKGTITIQD TGIGMTQEEL VSNLGTIARS GSKAFLEALQ NQAETSSKII
210 220 230 240 250
GQFGVGFYSA FMVADKVEVY SRSAAPESPG YQWLSDGSGV FEIAEASGVR
260 270 280 290 300
PGTKIIIHLK SDCKDFASES RVQDVVTKYS NFVSFPLYLN GKRINTLQAI
310 320 330 340 350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFT LHYKTDAPLN IRSIFYVPEM
360 370 380 390 400
KPSMFDVSRE LGSSVALYSR KVLIQTKAAD ILPKWLRFIR GVVDSEDIPL
410 420 430 440 450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM
460 470 480 490 500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLPDYAS RMQAGTRNIY
510 520 530 540 550
YLCAPNRHLA EHSPYYEAMK QKHTEVLFCY EQFDELTLLH LREFDKKKLI
560 570 580 590 600
SVETDIVVDH YKEEKFEDTS PADERLSEKE TEDLMAWMRN ALGSRVTNVK
610 620 630 640 650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH
660 670 680 690 700
TLIKKLCQLR ESEPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV
KVLEKH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R1P4 | S4R1P4_MOUSE | Heat shock protein 75 kDa, mitochon... | Trap1 | 113 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002409 mRNA Translation: BAB22078.1 AK010341 mRNA Translation: BAB26865.1 AK088471 mRNA Translation: BAC40374.1 BC022912 mRNA Translation: AAH22912.1 |
CCDSi | CCDS27914.1 |
RefSeqi | NP_080784.1, NM_026508.2 |
Genome annotation databases
Ensembli | ENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981 |
GeneIDi | 68015 |
KEGGi | mmu:68015 |
UCSCi | uc007xzk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002409 mRNA Translation: BAB22078.1 AK010341 mRNA Translation: BAB26865.1 AK088471 mRNA Translation: BAC40374.1 BC022912 mRNA Translation: AAH22912.1 |
CCDSi | CCDS27914.1 |
RefSeqi | NP_080784.1, NM_026508.2 |
3D structure databases
SMRi | Q9CQN1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212597, 19 interactors |
IntActi | Q9CQN1, 5 interactors |
MINTi | Q9CQN1 |
STRINGi | 10090.ENSMUSP00000006137 |
PTM databases
iPTMneti | Q9CQN1 |
PhosphoSitePlusi | Q9CQN1 |
SwissPalmi | Q9CQN1 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9CQN1 |
Proteomic databases
EPDi | Q9CQN1 |
jPOSTi | Q9CQN1 |
MaxQBi | Q9CQN1 |
PaxDbi | Q9CQN1 |
PeptideAtlasi | Q9CQN1 |
PRIDEi | Q9CQN1 |
Protocols and materials databases
Antibodypediai | 3798, 661 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981 |
GeneIDi | 68015 |
KEGGi | mmu:68015 |
UCSCi | uc007xzk.1, mouse |
Organism-specific databases
CTDi | 10131 |
MGIi | MGI:1915265, Trap1 |
Phylogenomic databases
eggNOGi | KOG0019, Eukaryota |
GeneTreei | ENSGT00950000182747 |
HOGENOMi | CLU_006684_3_1_1 |
InParanoidi | Q9CQN1 |
OMAi | VITVEEM |
OrthoDBi | 924636at2759 |
PhylomeDBi | Q9CQN1 |
TreeFami | TF315234 |
Miscellaneous databases
BioGRID-ORCSi | 68015, 1 hit in 18 CRISPR screens |
ChiTaRSi | Trap1, mouse |
PROi | PR:Q9CQN1 |
RNActi | Q9CQN1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005981, Expressed in cortex of kidney and 288 other tissues |
ExpressionAtlasi | Q9CQN1, baseline and differential |
Genevisiblei | Q9CQN1, MM |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAP1_MOUSE | |
Accessioni | Q9CQN1Primary (citable) accession number: Q9CQN1 Secondary accession number(s): Q542I4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 13, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families