Trap1

Functionⁱ

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	121	ATPBy similarity	1
Binding siteⁱ	160	ATPBy similarity	1
Binding siteⁱ	173	ATPBy similarity	1
Binding siteⁱ	207	ATP; via amide nitrogenBy similarity	1
Binding siteⁱ	404	ATPBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein kinase binding Source: ParkinsonsUK-UCL
RNA binding Source: ParkinsonsUK-UCL
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cellular respiration Source: UniProtKB
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source: ParkinsonsUK-UCL
protein folding Source: InterPro
translational attenuation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock protein 75 kDa, mitochondrial Short name: HSP 75 Alternative name(s): TNFR-associated protein 1 Tumor necrosis factor type 1 receptor-associated protein Short name: TRAP-1
Gene namesⁱ	Name:Trap1 Synonyms:Hsp75
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:1915265 Trap1

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 60	MitochondrionBy similarityAdd BLAST		60
ChainⁱPRO_0000013605	61 – 706	Heat shock protein 75 kDa, mitochondrialAdd BLAST		646

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	172	PhosphoserineBy similarity	1
Modified residueⁱ	176	PhosphothreonineBy similarity	1
Modified residueⁱ	196	PhosphoserineBy similarity	1
Modified residueⁱ	264	N6-acetyllysineCombined sources	1
Modified residueⁱ	326	N6-acetyllysineCombined sources	1
Modified residueⁱ	334	N6-acetyllysineBy similarity	1
Modified residueⁱ	426	N6-acetyllysineCombined sources	1
Modified residueⁱ	433	N6-acetyllysineCombined sources	1
Modified residueⁱ	468	N6-acetyllysineBy similarity	1
Modified residueⁱ	496	PhosphothreonineBy similarity	1
Modified residueⁱ	570	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9CQN1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CQN1
PaxDbⁱ	Q9CQN1
PeptideAtlas More...PeptideAtlasⁱ	Q9CQN1
PRIDEⁱ	Q9CQN1

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9CQN1

REPRODUCTION-2DPAGEⁱ

Q9CQN1

PTM databases

iPTMnetⁱ	Q9CQN1
PhosphoSitePlusⁱ	Q9CQN1
SwissPalmⁱ	Q9CQN1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005981 Expressed in 271 organ(s), highest expression level in paneth cell
CleanExⁱ	MM_TRAP1
ExpressionAtlasⁱ	Q9CQN1 baseline and differential
Genevisibleⁱ	Q9CQN1 MM

Interactionⁱ

Subunit structureⁱ

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

GO - Molecular functionⁱ

protein kinase binding Source: ParkinsonsUK-UCL
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	212597, 5 interactors
IntActⁱ	Q9CQN1, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9CQN1
STRINGⁱ	10090.ENSMUSP00000006137

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CQN1
SMRⁱ	Q9CQN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heat shock protein 90 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0019 Eukaryota COG0326 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149016
HOGENOMⁱ	HOG000031987
HOVERGENⁱ	HBG103147
InParanoidⁱ	Q9CQN1
KEGG Orthology (KO) More...KOⁱ	K09488
OMAⁱ	YTRKVLI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03C9
PhylomeDBⁱ	Q9CQN1
TreeFamⁱ	TF315234

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00075 HATPase_c, 1 hit
Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505 HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR037196 HSP90_C IPR001404 Hsp90_fam IPR020575 Hsp90_N IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528 PTHR11528, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00183 HSP90, 1 hit
PIRSFⁱ	PIRSF002583 Hsp90, 1 hit
PRINTSⁱ	PR00775 HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387 HATPase_c, 1 hit
SUPFAMⁱ	SSF110942 SSF110942, 1 hit SSF54211 SSF54211, 1 hit SSF55874 SSF55874, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9CQN1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MACELRAVLL WGRGLQTVLR APALAGVRRG KPVLHLQKTT VQFRGPTQSL 
        60         70         80         90        100
ASGISAGQLY STQAAEDKEE ESLHSIISNT EAVRGSVSKH EFQAETKKLL 
       110        120        130        140        150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKLVCEGQVL PEMEIHLQTD 
       160        170        180        190        200
AKKGTITIQD TGIGMTQEEL VSNLGTIARS GSKAFLEALQ NQAETSSKII 
       210        220        230        240        250
GQFGVGFYSA FMVADKVEVY SRSAAPESPG YQWLSDGSGV FEIAEASGVR 
       260        270        280        290        300
PGTKIIIHLK SDCKDFASES RVQDVVTKYS NFVSFPLYLN GKRINTLQAI 
       310        320        330        340        350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFT LHYKTDAPLN IRSIFYVPEM 
       360        370        380        390        400
KPSMFDVSRE LGSSVALYSR KVLIQTKAAD ILPKWLRFIR GVVDSEDIPL 
       410        420        430        440        450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM 
       460        470        480        490        500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLPDYAS RMQAGTRNIY 
       510        520        530        540        550
YLCAPNRHLA EHSPYYEAMK QKHTEVLFCY EQFDELTLLH LREFDKKKLI 
       560        570        580        590        600
SVETDIVVDH YKEEKFEDTS PADERLSEKE TEDLMAWMRN ALGSRVTNVK 
       610        620        630        640        650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH 
       660        670        680        690        700
TLIKKLCQLR ESEPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV 

KVLEKH

Length:706

Mass (Da):80,209

Last modified:June 1, 2001 - v1

Checksum:ⁱ7183CE538CB36464

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	S4R1P4	S4R1P4_MOUSE		Heat shock protein 75 kDa, mitochon... Heat shock protein 75 kDa, mitochondrial	Trap1	113	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002409 mRNA Translation: BAB22078.1 AK010341 mRNA Translation: BAB26865.1 AK088471 mRNA Translation: BAC40374.1 BC022912 mRNA Translation: AAH22912.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27914.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080784.1, NM_026508.2
UniGeneⁱ	Mm.123366

Genome annotation databases

Ensemblⁱ	ENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981
GeneIDⁱ	68015
KEGGⁱ	mmu:68015
UCSC genome browser More...UCSCⁱ	uc007xzk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9CQN1	Trap1 protein (Fragment)		MOUSE		705	UniRef100_Q9CQN1

Protein	Similar proteins		Species	Score	Length	Source
Q9CQN1	Heat shock protein 75 kDa, mitochondrial		RAT		706	UniRef90_Q5XHZ0
Trap1 protein (Fragment)		MOUSE		705
heat shock protein 75 kDa, mitochondrial		MESAU		706
Heat shock protein 75 kDa, mitochondrial		CRIGR		706
Uncharacterized protein		NEOLE		706
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9CQN1	Heat shock protein 75 kDa, mitochondrial	)	HUMAN		704	UniRef50_Q12931
Heat shock protein 75 kDa, mitochondrial		BOVIN		703
Heat shock protein 75 kDa, mitochondrial		RAT		706
Heat shock protein 75 kDa, mitochondrial		PANTR		732
TRAP1 isoform 17 (Fragment)		PONAB		58
+604

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002409 mRNA Translation: BAB22078.1 AK010341 mRNA Translation: BAB26865.1 AK088471 mRNA Translation: BAC40374.1 BC022912 mRNA Translation: AAH22912.1
CCDSⁱ	CCDS27914.1
RefSeqⁱ	NP_080784.1, NM_026508.2
UniGeneⁱ	Mm.123366

3D structure databases

ProteinModelPortalⁱ	Q9CQN1
SMRⁱ	Q9CQN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212597, 5 interactors
IntActⁱ	Q9CQN1, 5 interactors
MINTⁱ	Q9CQN1
STRINGⁱ	10090.ENSMUSP00000006137

PTM databases

iPTMnetⁱ	Q9CQN1
PhosphoSitePlusⁱ	Q9CQN1
SwissPalmⁱ	Q9CQN1

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q9CQN1

REPRODUCTION-2DPAGEⁱ

Q9CQN1

Proteomic databases

EPDⁱ	Q9CQN1
MaxQBⁱ	Q9CQN1
PaxDbⁱ	Q9CQN1
PeptideAtlasⁱ	Q9CQN1
PRIDEⁱ	Q9CQN1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981
GeneIDⁱ	68015
KEGGⁱ	mmu:68015
UCSCⁱ	uc007xzk.1 mouse

Organism-specific databases

CTDⁱ	10131
MGIⁱ	MGI:1915265 Trap1

Phylogenomic databases

eggNOGⁱ	KOG0019 Eukaryota COG0326 LUCA
GeneTreeⁱ	ENSGT00920000149016
HOGENOMⁱ	HOG000031987
HOVERGENⁱ	HBG103147
InParanoidⁱ	Q9CQN1
KOⁱ	K09488
OMAⁱ	YTRKVLI
OrthoDBⁱ	EOG091G03C9
PhylomeDBⁱ	Q9CQN1
TreeFamⁱ	TF315234

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9CQN1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005981 Expressed in 271 organ(s), highest expression level in paneth cell
CleanExⁱ	MM_TRAP1
ExpressionAtlasⁱ	Q9CQN1 baseline and differential
Genevisibleⁱ	Q9CQN1 MM

Family and domain databases

CDDⁱ	cd00075 HATPase_c, 1 hit
Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505 HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR037196 HSP90_C IPR001404 Hsp90_fam IPR020575 Hsp90_N IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528 PTHR11528, 1 hit
Pfamⁱ	View protein in Pfam PF00183 HSP90, 1 hit
PIRSFⁱ	PIRSF002583 Hsp90, 1 hit
PRINTSⁱ	PR00775 HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387 HATPase_c, 1 hit
SUPFAMⁱ	SSF110942 SSF110942, 1 hit SSF54211 SSF54211, 1 hit SSF55874 SSF55874, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRAP1_MOUSE
Accessionⁱ	Q9CQN1Primary (citable) accession number: Q9CQN1 Secondary accession number(s): Q542I4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9CQN1 (TRAP1_MOUSE)

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Heat shock protein 75 kDa, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ