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Protein

Heat shock protein 75 kDa, mitochondrial

Gene

Trap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121ATPBy similarity1
Binding sitei160ATPBy similarity1
Binding sitei173ATPBy similarity1
Binding sitei207ATP; via amide nitrogenBy similarity1
Binding sitei404ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:Trap1
Synonyms:Hsp75
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915265 Trap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 60MitochondrionBy similarityAdd BLAST60
ChainiPRO_000001360561 – 706Heat shock protein 75 kDa, mitochondrialAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1
Modified residuei176PhosphothreonineBy similarity1
Modified residuei196PhosphoserineBy similarity1
Modified residuei264N6-acetyllysineCombined sources1
Modified residuei326N6-acetyllysineCombined sources1
Modified residuei334N6-acetyllysineBy similarity1
Modified residuei426N6-acetyllysineCombined sources1
Modified residuei433N6-acetyllysineCombined sources1
Modified residuei468N6-acetyllysineBy similarity1
Modified residuei496PhosphothreonineBy similarity1
Modified residuei570PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQN1
MaxQBiQ9CQN1
PaxDbiQ9CQN1
PeptideAtlasiQ9CQN1
PRIDEiQ9CQN1

2D gel databases

REPRODUCTION-2DPAGEiQ9CQN1

PTM databases

iPTMnetiQ9CQN1
PhosphoSitePlusiQ9CQN1
SwissPalmiQ9CQN1

Expressioni

Gene expression databases

BgeeiENSMUSG00000005981 Expressed in 271 organ(s), highest expression level in paneth cell
CleanExiMM_TRAP1
ExpressionAtlasiQ9CQN1 baseline and differential
GenevisibleiQ9CQN1 MM

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212597, 5 interactors
IntActiQ9CQN1, 5 interactors
MINTiQ9CQN1
STRINGi10090.ENSMUSP00000006137

Structurei

3D structure databases

ProteinModelPortaliQ9CQN1
SMRiQ9CQN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00920000149016
HOGENOMiHOG000031987
HOVERGENiHBG103147
InParanoidiQ9CQN1
KOiK09488
OMAiYTRKVLI
OrthoDBiEOG091G03C9
PhylomeDBiQ9CQN1
TreeFamiTF315234

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACELRAVLL WGRGLQTVLR APALAGVRRG KPVLHLQKTT VQFRGPTQSL
60 70 80 90 100
ASGISAGQLY STQAAEDKEE ESLHSIISNT EAVRGSVSKH EFQAETKKLL
110 120 130 140 150
DIVARSLYSE KEVFIRELIS NASDALEKLR HKLVCEGQVL PEMEIHLQTD
160 170 180 190 200
AKKGTITIQD TGIGMTQEEL VSNLGTIARS GSKAFLEALQ NQAETSSKII
210 220 230 240 250
GQFGVGFYSA FMVADKVEVY SRSAAPESPG YQWLSDGSGV FEIAEASGVR
260 270 280 290 300
PGTKIIIHLK SDCKDFASES RVQDVVTKYS NFVSFPLYLN GKRINTLQAI
310 320 330 340 350
WMMDPKDISE FQHEEFYRYI AQAYDKPRFT LHYKTDAPLN IRSIFYVPEM
360 370 380 390 400
KPSMFDVSRE LGSSVALYSR KVLIQTKAAD ILPKWLRFIR GVVDSEDIPL
410 420 430 440 450
NLSRELLQES ALIRKLRDVL QQRLIKFFID QSKKDAEKYA KFFEDYGLFM
460 470 480 490 500
REGIVTTAEQ DIKEDIAKLL RYESSALPAG QLTSLPDYAS RMQAGTRNIY
510 520 530 540 550
YLCAPNRHLA EHSPYYEAMK QKHTEVLFCY EQFDELTLLH LREFDKKKLI
560 570 580 590 600
SVETDIVVDH YKEEKFEDTS PADERLSEKE TEDLMAWMRN ALGSRVTNVK
610 620 630 640 650
VTFRLDTHPA MVTVLEMGAA RHFLRMQQLA KTQEERAQLL QPTLEINPRH
660 670 680 690 700
TLIKKLCQLR ESEPELAQLL VDQIYENAMI AAGLVDDPRA MVGRLNDLLV

KVLEKH
Length:706
Mass (Da):80,209
Last modified:June 1, 2001 - v1
Checksum:i7183CE538CB36464
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1P4S4R1P4_MOUSE
Heat shock protein 75 kDa, mitochon...
Trap1
113Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002409 mRNA Translation: BAB22078.1
AK010341 mRNA Translation: BAB26865.1
AK088471 mRNA Translation: BAC40374.1
BC022912 mRNA Translation: AAH22912.1
CCDSiCCDS27914.1
RefSeqiNP_080784.1, NM_026508.2
UniGeneiMm.123366

Genome annotation databases

EnsembliENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981
GeneIDi68015
KEGGimmu:68015
UCSCiuc007xzk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002409 mRNA Translation: BAB22078.1
AK010341 mRNA Translation: BAB26865.1
AK088471 mRNA Translation: BAC40374.1
BC022912 mRNA Translation: AAH22912.1
CCDSiCCDS27914.1
RefSeqiNP_080784.1, NM_026508.2
UniGeneiMm.123366

3D structure databases

ProteinModelPortaliQ9CQN1
SMRiQ9CQN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212597, 5 interactors
IntActiQ9CQN1, 5 interactors
MINTiQ9CQN1
STRINGi10090.ENSMUSP00000006137

PTM databases

iPTMnetiQ9CQN1
PhosphoSitePlusiQ9CQN1
SwissPalmiQ9CQN1

2D gel databases

REPRODUCTION-2DPAGEiQ9CQN1

Proteomic databases

EPDiQ9CQN1
MaxQBiQ9CQN1
PaxDbiQ9CQN1
PeptideAtlasiQ9CQN1
PRIDEiQ9CQN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006137; ENSMUSP00000006137; ENSMUSG00000005981
GeneIDi68015
KEGGimmu:68015
UCSCiuc007xzk.1 mouse

Organism-specific databases

CTDi10131
MGIiMGI:1915265 Trap1

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00920000149016
HOGENOMiHOG000031987
HOVERGENiHBG103147
InParanoidiQ9CQN1
KOiK09488
OMAiYTRKVLI
OrthoDBiEOG091G03C9
PhylomeDBiQ9CQN1
TreeFamiTF315234

Miscellaneous databases

PROiPR:Q9CQN1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005981 Expressed in 271 organ(s), highest expression level in paneth cell
CleanExiMM_TRAP1
ExpressionAtlasiQ9CQN1 baseline and differential
GenevisibleiQ9CQN1 MM

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQN1
Secondary accession number(s): Q542I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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