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Protein

ER lumen protein-retaining receptor 2

Gene

Kdelr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • protein retention in ER lumen Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
Gene namesi
Name:Kdelr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914163 Kdelr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941561 – 212ER lumen protein-retaining receptor 2Add BLAST212

Proteomic databases

MaxQBiQ9CQM2
PaxDbiQ9CQM2
PeptideAtlasiQ9CQM2
PRIDEiQ9CQM2

PTM databases

PhosphoSitePlusiQ9CQM2

Expressioni

Gene expression databases

BgeeiENSMUSG00000079111 Expressed in 311 organ(s), highest expression level in embryo
GenevisibleiQ9CQM2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106359

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiQ9CQM2
KOiK10949
OMAiQTTRSCR
OrthoDBiEOG091G0Q1H
PhylomeDBiQ9CQM2
TreeFamiTF314792

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKLIYIAC SYATVYLIYM KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,454
Last modified:June 1, 2001 - v1
Checksum:i774388DAF56FEC24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278133 mRNA Translation: CAC34585.1
AK003515 mRNA Translation: BAB22829.1
AK007403 mRNA Translation: BAB25016.1
AK150402 mRNA Translation: BAE29528.1
CT010232 mRNA Translation: CAJ18440.1
BC007146 mRNA Translation: AAH07146.1
CCDSiCCDS39369.1
RefSeqiNP_080117.1, NM_025841.4
UniGeneiMm.181880

Genome annotation databases

EnsembliENSMUST00000110731; ENSMUSP00000106359; ENSMUSG00000079111
GeneIDi66913
KEGGimmu:66913
UCSCiuc009akh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278133 mRNA Translation: CAC34585.1
AK003515 mRNA Translation: BAB22829.1
AK007403 mRNA Translation: BAB25016.1
AK150402 mRNA Translation: BAE29528.1
CT010232 mRNA Translation: CAJ18440.1
BC007146 mRNA Translation: AAH07146.1
CCDSiCCDS39369.1
RefSeqiNP_080117.1, NM_025841.4
UniGeneiMm.181880

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106359

PTM databases

PhosphoSitePlusiQ9CQM2

Proteomic databases

MaxQBiQ9CQM2
PaxDbiQ9CQM2
PeptideAtlasiQ9CQM2
PRIDEiQ9CQM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110731; ENSMUSP00000106359; ENSMUSG00000079111
GeneIDi66913
KEGGimmu:66913
UCSCiuc009akh.2 mouse

Organism-specific databases

CTDi11014
MGIiMGI:1914163 Kdelr2

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiQ9CQM2
KOiK10949
OMAiQTTRSCR
OrthoDBiEOG091G0Q1H
PhylomeDBiQ9CQM2
TreeFamiTF314792

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q9CQM2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079111 Expressed in 311 organ(s), highest expression level in embryo
GenevisibleiQ9CQM2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERD22_MOUSE
AccessioniPrimary (citable) accession number: Q9CQM2
Secondary accession number(s): Q4FK20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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