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Protein

RAD52 motif-containing protein 1

Gene

Rdm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RAD52 motif-containing protein 1
Gene namesi
Name:Rdm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913849 Rdm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995301 – 281RAD52 motif-containing protein 1Add BLAST281

Proteomic databases

PaxDbiQ9CQK3
PRIDEiQ9CQK3

PTM databases

PhosphoSitePlusiQ9CQK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000010362
CleanExiMM_RDM1
ExpressionAtlasiQ9CQK3 baseline and differential
GenevisibleiQ9CQK3 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi211585, 1 interactor
STRINGi10090.ENSMUSP00000010506

Structurei

3D structure databases

ProteinModelPortaliQ9CQK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 98RRMPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92Necessary for nuclear localization and for nucleolar accumulation in response to heat shockBy similarityAdd BLAST92
Regioni90 – 133Necessary for nuclear and nucleolar localizationBy similarityAdd BLAST44

Domaini

C-terminal half contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.By similarity

Phylogenomic databases

eggNOGiENOG410IFY2 Eukaryota
ENOG41123Y3 LUCA
GeneTreeiENSGT00390000018397
HOGENOMiHOG000015383
HOVERGENiHBG105575
InParanoidiQ9CQK3
KOiK10874
OMAiYDCRSPG
OrthoDBiEOG091G0J48
PhylomeDBiQ9CQK3
TreeFamiTF101222

Family and domain databases

CDDicd12364 RRM_RDM1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034200 RDM1_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELISFVVP TQSDKVLLVW DLSTGPPAEA LSHSLFTVFS QFGLLYSVRV
60 70 80 90 100
FPNAAVARPG FYAIIKFYSS RDAQRAQKAC DGKPLFQTSP VKVRLGTRHK
110 120 130 140 150
ALQHQAFALN SSRCQELANY YFGFSGWSKR IIKLQELSGL EDAALAVPMQ
160 170 180 190 200
KGSPQFLCAV EVVLPPYGCR SPGVGISEEP LRQLEEGQSS FLMKRKTAQK
210 220 230 240 250
LAFQAAVSDA FQKLTIVVLE SGRIAVEYRP TAEDLDARSE EELQNLIQVS
260 270 280
CSSWSQSSQR EEECLSDFSL EEEDLKLCDP H
Length:281
Mass (Da):31,235
Last modified:June 1, 2001 - v1
Checksum:i7FDB5CB5F2579CCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003135 mRNA Translation: BAB22595.1
AK010457 mRNA Translation: BAB26954.1
AL590994 Genomic DNA No translation available.
BC026811 mRNA Translation: AAH26811.1
BC055013 mRNA Translation: AAH55013.1
CCDSiCCDS25477.1
RefSeqiNP_079930.1, NM_025654.2
UniGeneiMm.41449

Genome annotation databases

EnsembliENSMUST00000010506; ENSMUSP00000010506; ENSMUSG00000010362
GeneIDi66599
KEGGimmu:66599
UCSCiuc007lpp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRDM1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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