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Protein

Density-regulated protein

Gene

Denr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein
Short name:
DRP
Gene namesi
Name:Denr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915434 Denr

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001306012 – 198Density-regulated proteinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQJ6
MaxQBiQ9CQJ6
PaxDbiQ9CQJ6
PeptideAtlasiQ9CQJ6
PRIDEiQ9CQJ6

PTM databases

iPTMnetiQ9CQJ6
PhosphoSitePlusiQ9CQJ6
SwissPalmiQ9CQJ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000023106
CleanExiMM_DENR
ExpressionAtlasiQ9CQJ6 baseline and differential
GenevisibleiQ9CQJ6 MM

Interactioni

Subunit structurei

Interacts with MCTS1.By similarity

Protein-protein interaction databases

BioGridi212709, 1 interactor
STRINGi10090.ENSMUSP00000023869

Structurei

3D structure databases

ProteinModelPortaliQ9CQJ6
SMRiQ9CQJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 182SUI1PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the DENR family.Curated

Phylogenomic databases

eggNOGiKOG3239 Eukaryota
COG0023 LUCA
GeneTreeiENSGT00390000014349
HOGENOMiHOG000237611
HOVERGENiHBG005471
InParanoidiQ9CQJ6
OMAiSGGHDCK
OrthoDBiEOG091G0R9X
PhylomeDBiQ9CQJ6
TreeFamiTF105912

Family and domain databases

InterProiView protein in InterPro
IPR005873 Drp1
IPR001950 SUI1
IPR005872 SUI1_arc_bac
IPR036877 SUI1_dom_sf
PANTHERiPTHR12789 PTHR12789, 1 hit
PfamiView protein in Pfam
PF01253 SUI1, 1 hit
SUPFAMiSSF55159 SSF55159, 2 hits
TIGRFAMsiTIGR01159 DRP1, 1 hit
PROSITEiView protein in PROSITE
PS50296 SUI1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDISESSG ADCKGDTKNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV
60 70 80 90 100
AKCRQWLEKN FPNEFAKLTV ENSPKQETGI TEGQGPVGEE EEKKKQKRGG
110 120 130 140 150
RGQIKQKKKT VPQKVTIAKI PRAKKKYVTR VCGLATFEID LKEAQRFFAQ
160 170 180 190
KFSCGASVTG EDEIIIQGDF TDDIIDVIQE KWPEVDDDSI EDLGEVKK
Length:198
Mass (Da):22,166
Last modified:April 27, 2001 - v1
Checksum:i8482AA9E13E27A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017647 mRNA Translation: BAB30854.1
AK018762 mRNA Translation: BAB31392.1
AK135127 mRNA Translation: BAE22432.1
BC043922 mRNA Translation: AAH43922.1
CCDSiCCDS39275.1
RefSeqiNP_080879.1, NM_026603.4
UniGeneiMm.28549

Genome annotation databases

EnsembliENSMUST00000023869; ENSMUSP00000023869; ENSMUSG00000023106
GeneIDi68184
KEGGimmu:68184
UCSCiuc008zor.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDENR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQJ6
Secondary accession number(s): Q3UXY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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