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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

Ndufb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:Ndufb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1913296 Ndufb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000002005347 – 189NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialAdd BLAST143

Proteomic databases

EPDiQ9CQH3
MaxQBiQ9CQH3
PaxDbiQ9CQH3
PeptideAtlasiQ9CQH3
PRIDEiQ9CQH3

PTM databases

iPTMnetiQ9CQH3
PhosphoSitePlusiQ9CQH3

Expressioni

Gene expression databases

BgeeiENSMUSG00000027673
ExpressionAtlasiQ9CQH3 baseline and differential
GenevisibleiQ9CQH3 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211174, 2 interactors
ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiQ9CQH3
IntActiQ9CQH3, 4 interactors
MINTiQ9CQH3
STRINGi10090.ENSMUSP00000114963

Structurei

3D structure databases

SMRiQ9CQH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4632 Eukaryota
ENOG4111HCK LUCA
GeneTreeiENSGT00390000009980
HOVERGENiHBG003008
InParanoidiQ9CQH3
KOiK03961
OMAiQWHKFKD
OrthoDBiEOG091G0L2T
PhylomeDBiQ9CQH3
TreeFamiTF313997

Family and domain databases

InterProiView protein in InterPro
IPR019173 NADH_UbQ_OxRdtase_B5_su
PANTHERiPTHR13178 PTHR13178, 1 hit
PfamiView protein in Pfam
PF09781 NDUF_B5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMSLLQRA SVSALTALSC RRAGPRLGVG SFLTRSFPKT VAPVRHSGDH
60 70 80 90 100
GKRLFVVKPS LYYDARFLRL MKFYLMLTGI PVIIGITLVN IFIGEAELAE
110 120 130 140 150
IPEGYIPEHW EYYKHPISRW IARNFYDGPE KNYEKTLAIL QIESEKAELR
160 170 180
LKEQEVRRLM RARGDGPWYQ FPTPEKEFID HSPKATPDN
Length:189
Mass (Da):21,710
Last modified:June 1, 2001 - v1
Checksum:i8D998EA6CD683DE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018562 mRNA Translation: BAB31277.1
AK004372 mRNA Translation: BAB23279.1
AK013223 mRNA Translation: BAB28724.1
BC025155 mRNA Translation: AAH25155.1
CCDSiCCDS17300.1
RefSeqiNP_079592.2, NM_025316.2
UniGeneiMm.28058

Genome annotation databases

EnsembliENSMUST00000127477; ENSMUSP00000114963; ENSMUSG00000027673
GeneIDi66046
KEGGimmu:66046
UCSCiuc008owq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUB5_MOUSE
AccessioniPrimary (citable) accession number: Q9CQH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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