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Protein

RNA transcription, translation and transport factor protein

Gene

RTRAF

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA transcription, translation and transport factor proteinImported
Gene namesi
Name:RTRAFImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915295 Rtraf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899571 – 244RNA transcription, translation and transport factor proteinAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20N6-acetyllysineBy similarity1
Modified residuei62N6-acetyllysineBy similarity1
Modified residuei98N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQE8
MaxQBiQ9CQE8
PaxDbiQ9CQE8
PRIDEiQ9CQE8

2D gel databases

REPRODUCTION-2DPAGEiQ9CQE8

PTM databases

iPTMnetiQ9CQE8
PhosphoSitePlusiQ9CQE8
SwissPalmiQ9CQE8

Expressioni

Gene expression databases

BgeeiENSMUSG00000021807 Expressed in 274 organ(s), highest expression level in bone fossa
CleanExiMM_2700060E02RIK
ExpressionAtlasiQ9CQE8 baseline and differential
GenevisibleiQ9CQE8 MM

Interactioni

Subunit structurei

Homodimer. Interacts with FAM98A (via N- and C-terminus). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212624, 4 interactors
IntActiQ9CQE8, 6 interactors
MINTiQ9CQE8
STRINGi10090.ENSMUSP00000022341

Structurei

3D structure databases

ProteinModelPortaliQ9CQE8
SMRiQ9CQE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RTRAF family.Curated

Phylogenomic databases

eggNOGiKOG4380 Eukaryota
ENOG410XRFT LUCA
GeneTreeiENSGT00390000005163
HOGENOMiHOG000039763
HOVERGENiHBG051035
InParanoidiQ9CQE8
KOiK15433
OMAiPMRILRL
OrthoDBiEOG091G0JMY
PhylomeDBiQ9CQE8
TreeFamiTF323606

Family and domain databases

InterProiView protein in InterPro
IPR019265 RTRAF
PANTHERiPTHR15924 PTHR15924, 1 hit
PfamiView protein in Pfam
PF10036 RLL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRRKLTALD YHNPSGFNCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN
60 70 80 90 100
IHSSDWPKFF EKYLKDVNCP FKIQDRQEAI DWLLGLAVRL EYGDNAEKYK
110 120 130 140 150
DLVPDNRKNT DNAAKNAEPL INLDVNNPDF KAGVMALANL LQIQRHDDYL
160 170 180 190 200
VMLKAIRILV QERLTQDAVA KANQTKEGLP VALEKHILGF DTGDAVLNEA
210 220 230 240
AQILRLLHIE ELRELQTKIN EAIVAVQAII ADPKTDHRLG KVGR
Length:244
Mass (Da):28,152
Last modified:June 1, 2001 - v1
Checksum:i973961CDEB52BBDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003732 mRNA Translation: BAB22966.1
AK012460 mRNA Translation: BAB28255.1
AK012486 mRNA Translation: BAB28273.1
BC048357 mRNA Translation: AAH48357.1
CCDSiCCDS26839.1
RefSeqiNP_080804.1, NM_026528.3
UniGeneiMm.21932

Genome annotation databases

EnsembliENSMUST00000022341; ENSMUSP00000022341; ENSMUSG00000021807
GeneIDi68045
KEGGimmu:68045
UCSCiuc007siv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003732 mRNA Translation: BAB22966.1
AK012460 mRNA Translation: BAB28255.1
AK012486 mRNA Translation: BAB28273.1
BC048357 mRNA Translation: AAH48357.1
CCDSiCCDS26839.1
RefSeqiNP_080804.1, NM_026528.3
UniGeneiMm.21932

3D structure databases

ProteinModelPortaliQ9CQE8
SMRiQ9CQE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212624, 4 interactors
IntActiQ9CQE8, 6 interactors
MINTiQ9CQE8
STRINGi10090.ENSMUSP00000022341

PTM databases

iPTMnetiQ9CQE8
PhosphoSitePlusiQ9CQE8
SwissPalmiQ9CQE8

2D gel databases

REPRODUCTION-2DPAGEiQ9CQE8

Proteomic databases

EPDiQ9CQE8
MaxQBiQ9CQE8
PaxDbiQ9CQE8
PRIDEiQ9CQE8

Protocols and materials databases

DNASUi68045
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022341; ENSMUSP00000022341; ENSMUSG00000021807
GeneIDi68045
KEGGimmu:68045
UCSCiuc007siv.1 mouse

Organism-specific databases

CTDi51637
MGIiMGI:1915295 Rtraf

Phylogenomic databases

eggNOGiKOG4380 Eukaryota
ENOG410XRFT LUCA
GeneTreeiENSGT00390000005163
HOGENOMiHOG000039763
HOVERGENiHBG051035
InParanoidiQ9CQE8
KOiK15433
OMAiPMRILRL
OrthoDBiEOG091G0JMY
PhylomeDBiQ9CQE8
TreeFamiTF323606

Miscellaneous databases

PROiPR:Q9CQE8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021807 Expressed in 274 organ(s), highest expression level in bone fossa
CleanExiMM_2700060E02RIK
ExpressionAtlasiQ9CQE8 baseline and differential
GenevisibleiQ9CQE8 MM

Family and domain databases

InterProiView protein in InterPro
IPR019265 RTRAF
PANTHERiPTHR15924 PTHR15924, 1 hit
PfamiView protein in Pfam
PF10036 RLL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTRAF_MOUSE
AccessioniPrimary (citable) accession number: Q9CQE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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