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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

Ergic3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: HGNC
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-84 homolog
Gene namesi
Name:Ergic3
Synonyms:Erv46, Sdbcag84
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913616 Ergic3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 341LumenalSequence analysisAdd BLAST295
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976411 – 383Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei116PhosphoserineBy similarity1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9CQE7
PaxDbiQ9CQE7
PeptideAtlasiQ9CQE7
PRIDEiQ9CQE7

PTM databases

iPTMnetiQ9CQE7
PhosphoSitePlusiQ9CQE7
SwissPalmiQ9CQE7

Expressioni

Tissue specificityi

Expression is particularly strong in liver, kidney and brain but is almost undetectable in heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000005881 Expressed in 282 organ(s), highest expression level in molar tooth
CleanExiMM_ERGIC3
ExpressionAtlasiQ9CQE7 baseline and differential
GenevisibleiQ9CQE7 MM

Interactioni

Subunit structurei

Interacts with ERGIC1/ERGIC32.By similarity

Protein-protein interaction databases

BioGridi211417, 1 interactor
IntActiQ9CQE7, 1 interactor
MINTiQ9CQE7
STRINGi10090.ENSMUSP00000006035

Structurei

3D structure databases

ProteinModelPortaliQ9CQE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOGENOMiHOG000210954
HOVERGENiHBG105706
InParanoidiQ9CQE7
KOiK20367
OMAiSWAFGRG
OrthoDBiEOG091G08NM
PhylomeDBiQ9CQE7
TreeFamiTF300739

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CQE7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKKRLDK DGVPVSSEAE RHELGKVEVT VFDPNSLDPN RCESCYGAES
160 170 180 190 200
EDIKCCNSCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIKHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,208
Last modified:June 1, 2001 - v1
Checksum:i97EF08712201E0C2
GO
Isoform 2 (identifier: Q9CQE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: V → VHAVEI
     239-239: N → NPSDCLQ

Show »
Length:394
Mass (Da):44,402
Checksum:i44BFD6F72316DD77
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RK81F6RK81_MOUSE
Endoplasmic reticulum-Golgi interme...
Ergic3
235Annotation score:
F6UIS1F6UIS1_MOUSE
Endoplasmic reticulum-Golgi interme...
Ergic3
246Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019209229V → VHAVEI in isoform 2. 1 Publication1
Alternative sequenceiVSP_019210239N → NPSDCLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009350 mRNA Translation: BAB26233.1
AK013942 mRNA Translation: BAB29073.1
AK050285 mRNA Translation: BAC34166.1
AL833786 Genomic DNA No translation available.
BC043720 mRNA Translation: AAH43720.1
BC057130 mRNA Translation: AAH57130.1
CCDSiCCDS16959.1 [Q9CQE7-1]
RefSeqiNP_079792.1, NM_025516.4 [Q9CQE7-1]
UniGeneiMm.141276

Genome annotation databases

EnsembliENSMUST00000006035; ENSMUSP00000006035; ENSMUSG00000005881 [Q9CQE7-1]
ENSMUST00000088650; ENSMUSP00000086025; ENSMUSG00000005881 [Q9CQE7-2]
GeneIDi66366
KEGGimmu:66366
UCSCiuc008nlx.1 mouse [Q9CQE7-1]
uc008nly.1 mouse [Q9CQE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009350 mRNA Translation: BAB26233.1
AK013942 mRNA Translation: BAB29073.1
AK050285 mRNA Translation: BAC34166.1
AL833786 Genomic DNA No translation available.
BC043720 mRNA Translation: AAH43720.1
BC057130 mRNA Translation: AAH57130.1
CCDSiCCDS16959.1 [Q9CQE7-1]
RefSeqiNP_079792.1, NM_025516.4 [Q9CQE7-1]
UniGeneiMm.141276

3D structure databases

ProteinModelPortaliQ9CQE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211417, 1 interactor
IntActiQ9CQE7, 1 interactor
MINTiQ9CQE7
STRINGi10090.ENSMUSP00000006035

PTM databases

iPTMnetiQ9CQE7
PhosphoSitePlusiQ9CQE7
SwissPalmiQ9CQE7

Proteomic databases

EPDiQ9CQE7
PaxDbiQ9CQE7
PeptideAtlasiQ9CQE7
PRIDEiQ9CQE7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006035; ENSMUSP00000006035; ENSMUSG00000005881 [Q9CQE7-1]
ENSMUST00000088650; ENSMUSP00000086025; ENSMUSG00000005881 [Q9CQE7-2]
GeneIDi66366
KEGGimmu:66366
UCSCiuc008nlx.1 mouse [Q9CQE7-1]
uc008nly.1 mouse [Q9CQE7-2]

Organism-specific databases

CTDi51614
MGIiMGI:1913616 Ergic3

Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOGENOMiHOG000210954
HOVERGENiHBG105706
InParanoidiQ9CQE7
KOiK20367
OMAiSWAFGRG
OrthoDBiEOG091G08NM
PhylomeDBiQ9CQE7
TreeFamiTF300739

Miscellaneous databases

ChiTaRSiErgic3 mouse
PROiPR:Q9CQE7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005881 Expressed in 282 organ(s), highest expression level in molar tooth
CleanExiMM_ERGIC3
ExpressionAtlasiQ9CQE7 baseline and differential
GenevisibleiQ9CQE7 MM

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERGI3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQE7
Secondary accession number(s): B7ZCN9, Q6PGA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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