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Protein

Histone chaperone ASF1A

Gene

Asf1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.By similarity

GO - Molecular functioni

  • chromatin binding Source: MGI
  • histone binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone chaperone ASF1A
Alternative name(s):
Anti-silencing function protein 1 homolog A
Gene namesi
Name:Asf1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913653 Asf1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002840131 – 204Histone chaperone ASF1AAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192Phosphoserine; by TLK2By similarity1

Post-translational modificationi

Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQE6
MaxQBiQ9CQE6
PaxDbiQ9CQE6
PeptideAtlasiQ9CQE6
PRIDEiQ9CQE6

PTM databases

iPTMnetiQ9CQE6
PhosphoSitePlusiQ9CQE6

Expressioni

Gene expression databases

BgeeiENSMUSG00000019857 Expressed in 305 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9CQE6 baseline and differential
GenevisibleiQ9CQE6 MM

Interactioni

Subunit structurei

Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1 (By similarity). Interacts with CDAN1 (By similarity). Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211447, 3 interactors
IntActiQ9CQE6, 5 interactors
STRINGi10090.ENSMUSP00000020004

Structurei

3D structure databases

ProteinModelPortaliQ9CQE6
SMRiQ9CQE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 156Interaction with histone H3, CHAF1B, and HIRABy similarityAdd BLAST156
Regioni155 – 204Required for interaction with HIRABy similarityAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 37Required for interaction with HIRABy similarity7

Sequence similaritiesi

Belongs to the ASF1 family.Curated

Phylogenomic databases

eggNOGiKOG3265 Eukaryota
COG5137 LUCA
GeneTreeiENSGT00390000004692
HOGENOMiHOG000197425
HOVERGENiHBG105617
InParanoidiQ9CQE6
KOiK10753
OMAiFNPFQFE
OrthoDBiEOG091G0K07
PhylomeDBiQ9CQE6
TreeFamiTF106429

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf
PANTHERiPTHR12040 PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729 ASF1_hist_chap, 1 hit
SUPFAMiSSF101546 SSF101546, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9CQE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES
60 70 80 90 100
EEYDQVLDSV LVGPVPAGRH MFVFQADAPN AGLIPDADAV GVTVVLITCT
110 120 130 140 150
YRGQEFIRVG YYVNNEYTET ELRENPPVKP DFSKLQRNIL ASNPRVTRFH
160 170 180 190 200
INWEDNTEKL EDAESSNPNL QSLLSTDALP SASKGWSTSE NSLNVMLESH

MDCM
Length:204
Mass (Da):22,943
Last modified:June 1, 2001 - v1
Checksum:i9803653A63B8FC68
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7K2A0A1W2P7K2_MOUSE
ASF1 anti-silencing function 1 homo...
Asf1a mCG_6312
134Annotation score:
A0A1W2P7E1A0A1W2P7E1_MOUSE
Histone chaperone ASF1A
Asf1a
118Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007804 mRNA Translation: BAB25269.1
AK010210 mRNA Translation: BAB26770.1
AK012376 mRNA Translation: BAB28198.1
AK088618 mRNA Translation: BAC40457.1
BC027628 mRNA Translation: AAH27628.1
CCDSiCCDS23847.1
RefSeqiNP_079817.1, NM_025541.3
UniGeneiMm.272989

Genome annotation databases

EnsembliENSMUST00000020004; ENSMUSP00000020004; ENSMUSG00000019857
GeneIDi66403
KEGGimmu:66403
UCSCiuc007fbr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007804 mRNA Translation: BAB25269.1
AK010210 mRNA Translation: BAB26770.1
AK012376 mRNA Translation: BAB28198.1
AK088618 mRNA Translation: BAC40457.1
BC027628 mRNA Translation: AAH27628.1
CCDSiCCDS23847.1
RefSeqiNP_079817.1, NM_025541.3
UniGeneiMm.272989

3D structure databases

ProteinModelPortaliQ9CQE6
SMRiQ9CQE6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211447, 3 interactors
IntActiQ9CQE6, 5 interactors
STRINGi10090.ENSMUSP00000020004

PTM databases

iPTMnetiQ9CQE6
PhosphoSitePlusiQ9CQE6

Proteomic databases

EPDiQ9CQE6
MaxQBiQ9CQE6
PaxDbiQ9CQE6
PeptideAtlasiQ9CQE6
PRIDEiQ9CQE6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020004; ENSMUSP00000020004; ENSMUSG00000019857
GeneIDi66403
KEGGimmu:66403
UCSCiuc007fbr.1 mouse

Organism-specific databases

CTDi25842
MGIiMGI:1913653 Asf1a

Phylogenomic databases

eggNOGiKOG3265 Eukaryota
COG5137 LUCA
GeneTreeiENSGT00390000004692
HOGENOMiHOG000197425
HOVERGENiHBG105617
InParanoidiQ9CQE6
KOiK10753
OMAiFNPFQFE
OrthoDBiEOG091G0K07
PhylomeDBiQ9CQE6
TreeFamiTF106429

Enzyme and pathway databases

ReactomeiR-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

PROiPR:Q9CQE6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019857 Expressed in 305 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9CQE6 baseline and differential
GenevisibleiQ9CQE6 MM

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf
PANTHERiPTHR12040 PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729 ASF1_hist_chap, 1 hit
SUPFAMiSSF101546 SSF101546, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASF1A_MOUSE
AccessioniPrimary (citable) accession number: Q9CQE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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