Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 10

Gene

Rgs10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 10
Short name:
RGS10
Gene namesi
Name:Rgs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915115 Rgs10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042081 – 181Regulator of G-protein signaling 10Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineCombined sources1
Lipidationi74S-palmitoyl cysteineBy similarity1
Modified residuei176PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9CQE5
MaxQBiQ9CQE5
PaxDbiQ9CQE5
PRIDEiQ9CQE5

PTM databases

iPTMnetiQ9CQE5
PhosphoSitePlusiQ9CQE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000030844 Expressed in 266 organ(s), highest expression level in blood
CleanExiMM_RGS10
ExpressionAtlasiQ9CQE5 baseline and differential
GenevisibleiQ9CQE5 MM

Interactioni

Subunit structurei

Interacts with GNAZ, GNAI1 and GNAI3. Associates specifically with the activated, GTP-bound forms of GNAZ and GNAI3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CQE5, 1 interactor
MINTiQ9CQE5
STRINGi10090.ENSMUSP00000033133

Structurei

3D structure databases

ProteinModelPortaliQ9CQE5
SMRiQ9CQE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 156RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9CQE5
KOiK16449
OMAiPKSTAKW
OrthoDBiEOG091G0BDG
PhylomeDBiQ9CQE5
TreeFamiTF315837

Family and domain databases

CDDicd08741 RGS_RGS10, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9CQE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE
60 70 80 90 100
GVQRFREFLK KEFSEENVLF WLACEDFKKT EDRKQMQEKA KEIYMTFLSN
110 120 130 140 150
KASSQVNVEG QSRLTEKILE EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD
160 170 180
LFLKPKRTEE EEEEPPDAQT AAKRASRIYN T
Length:181
Mass (Da):21,151
Last modified:June 1, 2001 - v1
Checksum:i9897860505962286
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1B6D3Z1B6_MOUSE
Regulator of G-protein-signaling 10
Rgs10
85Annotation score:
A0A0U1RPU5A0A0U1RPU5_MOUSE
Regulator of G-protein-signaling 10
Rgs10
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → E in BAB30688 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009686 mRNA Translation: BAB26440.1
AK009283 mRNA Translation: BAB26193.1
AK017314 mRNA Translation: BAB30688.1
AK088009 mRNA Translation: BAC40091.1
CCDSiCCDS21896.1
RefSeqiNP_080694.1, NM_026418.2
UniGeneiMm.18635

Genome annotation databases

EnsembliENSMUST00000033133; ENSMUSP00000033133; ENSMUSG00000030844
GeneIDi67865
KEGGimmu:67865
UCSCiuc009jyw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009686 mRNA Translation: BAB26440.1
AK009283 mRNA Translation: BAB26193.1
AK017314 mRNA Translation: BAB30688.1
AK088009 mRNA Translation: BAC40091.1
CCDSiCCDS21896.1
RefSeqiNP_080694.1, NM_026418.2
UniGeneiMm.18635

3D structure databases

ProteinModelPortaliQ9CQE5
SMRiQ9CQE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQE5, 1 interactor
MINTiQ9CQE5
STRINGi10090.ENSMUSP00000033133

PTM databases

iPTMnetiQ9CQE5
PhosphoSitePlusiQ9CQE5

Proteomic databases

EPDiQ9CQE5
MaxQBiQ9CQE5
PaxDbiQ9CQE5
PRIDEiQ9CQE5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033133; ENSMUSP00000033133; ENSMUSG00000030844
GeneIDi67865
KEGGimmu:67865
UCSCiuc009jyw.1 mouse

Organism-specific databases

CTDi6001
MGIiMGI:1915115 Rgs10

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9CQE5
KOiK16449
OMAiPKSTAKW
OrthoDBiEOG091G0BDG
PhylomeDBiQ9CQE5
TreeFamiTF315837

Miscellaneous databases

PROiPR:Q9CQE5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030844 Expressed in 266 organ(s), highest expression level in blood
CleanExiMM_RGS10
ExpressionAtlasiQ9CQE5 baseline and differential
GenevisibleiQ9CQE5 MM

Family and domain databases

CDDicd08741 RGS_RGS10, 1 hit
Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR037879 RGS10_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS10_MOUSE
AccessioniPrimary (citable) accession number: Q9CQE5
Secondary accession number(s): Q9D3L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again