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Protein

GTP-binding protein SAR1b

Gene

Sar1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi34MagnesiumBy similarity1
Metal bindingi75MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi75 – 78GTPBy similarity4
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-5694530 Cargo concentration in the ER
R-MMU-8963888 Chylomicron assembly
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein SAR1b
Gene namesi
Name:Sar1b
Synonyms:Sara1b, Sara2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913647 Sar1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062621 – 198GTP-binding protein SAR1bAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQC9
MaxQBiQ9CQC9
PaxDbiQ9CQC9
PRIDEiQ9CQC9
TopDownProteomicsiQ9CQC9

PTM databases

iPTMnetiQ9CQC9
PhosphoSitePlusiQ9CQC9

Expressioni

Gene expression databases

BgeeiENSMUSG00000020386 Expressed in 298 organ(s), highest expression level in vastus lateralis
CleanExiMM_SAR1B
ExpressionAtlasiQ9CQC9 baseline and differential
GenevisibleiQ9CQC9 MM

Interactioni

Subunit structurei

Homodimer. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity). Binds PREB.By similarity

Protein-protein interaction databases

BioGridi211441, 1 interactor
STRINGi10090.ENSMUSP00000020653

Structurei

3D structure databases

ProteinModelPortaliQ9CQC9
SMRiQ9CQC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. SAR1 family.Curated

Phylogenomic databases

eggNOGiKOG0077 Eukaryota
ENOG410YIKI LUCA
GeneTreeiENSGT00550000074696
HOGENOMiHOG000163690
HOVERGENiHBG104997
InParanoidiQ9CQC9
KOiK07953
OMAiWMAQYIN
OrthoDBiEOG091G0KFV
PhylomeDBiQ9CQC9
TreeFamiTF312890

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR006687 Small_GTPase_SAR1
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51422 SAR1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFIFDWIYS GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL
60 70 80 90 100
GQHVPTLHPT SEELTIAGMT FTTFDLGGHV QARRVWKNYL PAINGIVFLV
110 120 130 140 150
DCADHERLLE SKEELDSLMT DETIANVPIL ILGNKIDRPE AISEERLREM
160 170 180 190
FGLYGQTTGK GSVSLKELNA RPLEVFMCSV LKRQGYGEGF RWMAQYID
Length:198
Mass (Da):22,382
Last modified:June 1, 2001 - v1
Checksum:i9D0173C53FCD7A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002327 mRNA Translation: BAB22015.1
AK010187 mRNA Translation: BAB26755.1
AK013559 mRNA Translation: BAB28905.1
AK150906 mRNA Translation: BAE29948.1
BC082550 mRNA Translation: AAH82550.1
CCDSiCCDS24661.1
RefSeqiNP_079811.1, NM_025535.2
UniGeneiMm.196592

Genome annotation databases

EnsembliENSMUST00000020653; ENSMUSP00000020653; ENSMUSG00000020386
GeneIDi66397
KEGGimmu:66397
UCSCiuc007iup.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002327 mRNA Translation: BAB22015.1
AK010187 mRNA Translation: BAB26755.1
AK013559 mRNA Translation: BAB28905.1
AK150906 mRNA Translation: BAE29948.1
BC082550 mRNA Translation: AAH82550.1
CCDSiCCDS24661.1
RefSeqiNP_079811.1, NM_025535.2
UniGeneiMm.196592

3D structure databases

ProteinModelPortaliQ9CQC9
SMRiQ9CQC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211441, 1 interactor
STRINGi10090.ENSMUSP00000020653

PTM databases

iPTMnetiQ9CQC9
PhosphoSitePlusiQ9CQC9

Proteomic databases

EPDiQ9CQC9
MaxQBiQ9CQC9
PaxDbiQ9CQC9
PRIDEiQ9CQC9
TopDownProteomicsiQ9CQC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020653; ENSMUSP00000020653; ENSMUSG00000020386
GeneIDi66397
KEGGimmu:66397
UCSCiuc007iup.2 mouse

Organism-specific databases

CTDi51128
MGIiMGI:1913647 Sar1b

Phylogenomic databases

eggNOGiKOG0077 Eukaryota
ENOG410YIKI LUCA
GeneTreeiENSGT00550000074696
HOGENOMiHOG000163690
HOVERGENiHBG104997
InParanoidiQ9CQC9
KOiK07953
OMAiWMAQYIN
OrthoDBiEOG091G0KFV
PhylomeDBiQ9CQC9
TreeFamiTF312890

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-2132295 MHC class II antigen presentation
R-MMU-5694530 Cargo concentration in the ER
R-MMU-8963888 Chylomicron assembly
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

PROiPR:Q9CQC9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020386 Expressed in 298 organ(s), highest expression level in vastus lateralis
CleanExiMM_SAR1B
ExpressionAtlasiQ9CQC9 baseline and differential
GenevisibleiQ9CQC9 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
IPR006687 Small_GTPase_SAR1
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51422 SAR1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAR1B_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC9
Secondary accession number(s): Q3UBL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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