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Protein

Cdc42 effector protein 3

Gene

Cdc42ep3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-MMU-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 3
Alternative name(s):
Binder of Rho GTPases 2
Gene namesi
Name:Cdc42ep3
Synonyms:Borg2, Cep3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384718 Cdc42ep3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126521 – 254Cdc42 effector protein 3Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphotyrosineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CQC5
PaxDbiQ9CQC5
PRIDEiQ9CQC5

PTM databases

iPTMnetiQ9CQC5
PhosphoSitePlusiQ9CQC5

Expressioni

Gene expression databases

BgeeiENSMUSG00000036533 Expressed in 261 organ(s), highest expression level in urinary bladder
CleanExiMM_CDC42EP3
GenevisibleiQ9CQC5 MM

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067217

Structurei

3D structure databases

ProteinModelPortaliQ9CQC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 45CRIBPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi171 – 197Ser-richAdd BLAST27

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IHT2 Eukaryota
ENOG410Y5G0 LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ9CQC5
OMAiFDHPAPC
OrthoDBiEOG091G0MK0
PhylomeDBiQ9CQC5
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAKTPIYLK AANNKKGKKF KLRDILSPDM ISPPLGDFRH TIHIGKEGQH
60 70 80 90 100
DVFGDISFLQ GNYELLPGNQ EKAHSGQFPG HNDFFRANST SDSMFTETPS
110 120 130 140 150
PVLKNAISLP TIGGSQALML PLLSPVTFHS KQESFGRPKL PRLSCEPVME
160 170 180 190 200
EKVQEQSSLL ENGAVHQGDT SWGSSGSGSQ SSQGRDSHSS SLSEQSSDWP
210 220 230 240 250
ADDMFEHPAS CELVKSKTKS EESFSDLTGS LLSLQLDLGP SLLDEVLNVM

DKNK
Length:254
Mass (Da):27,686
Last modified:June 1, 2001 - v1
Checksum:i9EB9991CF1EB678F
GO

Sequence cautioni

The sequence BAC36479 differs from that shown. Reason: Frameshift at positions 167 and 205.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012309 mRNA Translation: BAB28155.1
AK014281 mRNA Translation: BAB29241.1
AK019447 mRNA Translation: BAB31723.1
AK076782 mRNA Translation: BAC36479.1 Frameshift.
AK150214 mRNA Translation: BAE29384.1
BC021409 mRNA Translation: AAH21409.1
BC034714 mRNA Translation: AAH34714.1
BC092297 mRNA Translation: AAH92297.1
CCDSiCCDS28984.1
RefSeqiNP_080790.1, NM_026514.2
XP_006524358.1, XM_006524295.3
UniGeneiMm.140601

Genome annotation databases

EnsembliENSMUST00000068958; ENSMUSP00000067217; ENSMUSG00000036533
GeneIDi260409
KEGGimmu:260409
UCSCiuc008dpx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012309 mRNA Translation: BAB28155.1
AK014281 mRNA Translation: BAB29241.1
AK019447 mRNA Translation: BAB31723.1
AK076782 mRNA Translation: BAC36479.1 Frameshift.
AK150214 mRNA Translation: BAE29384.1
BC021409 mRNA Translation: AAH21409.1
BC034714 mRNA Translation: AAH34714.1
BC092297 mRNA Translation: AAH92297.1
CCDSiCCDS28984.1
RefSeqiNP_080790.1, NM_026514.2
XP_006524358.1, XM_006524295.3
UniGeneiMm.140601

3D structure databases

ProteinModelPortaliQ9CQC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067217

PTM databases

iPTMnetiQ9CQC5
PhosphoSitePlusiQ9CQC5

Proteomic databases

MaxQBiQ9CQC5
PaxDbiQ9CQC5
PRIDEiQ9CQC5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068958; ENSMUSP00000067217; ENSMUSG00000036533
GeneIDi260409
KEGGimmu:260409
UCSCiuc008dpx.1 mouse

Organism-specific databases

CTDi10602
MGIiMGI:2384718 Cdc42ep3

Phylogenomic databases

eggNOGiENOG410IHT2 Eukaryota
ENOG410Y5G0 LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ9CQC5
OMAiFDHPAPC
OrthoDBiEOG091G0MK0
PhylomeDBiQ9CQC5
TreeFamiTF331725

Enzyme and pathway databases

ReactomeiR-MMU-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

PROiPR:Q9CQC5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036533 Expressed in 261 organ(s), highest expression level in urinary bladder
CleanExiMM_CDC42EP3
GenevisibleiQ9CQC5 MM

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBORG2_MOUSE
AccessioniPrimary (citable) accession number: Q9CQC5
Secondary accession number(s): Q3UD77, Q8BVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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