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Protein

Centrosomal protein of 19 kDa

Gene

Cep19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 19 kDa
Short name:
Cep19
Gene namesi
Name:Cep19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914244 Cep19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Severe obesity, hyperphagia, decreased energy expenditure, impaired whole-body fat oxidation, altered hepatic insulin signaling, and impaired glucose and insulin tolerance. Spermatogenic cells and seminiferous tubules show marked degeneration.1 Publication

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002519611 – 163Centrosomal protein of 19 kDaAdd BLAST163

Proteomic databases

PaxDbiQ9CQA8
PRIDEiQ9CQA8

PTM databases

iPTMnetiQ9CQA8
PhosphoSitePlusiQ9CQA8

Expressioni

Gene expression databases

BgeeiENSMUSG00000035790 Expressed in 275 organ(s), highest expression level in visual cortex
CleanExiMM_1500031L02RIK
GenevisibleiQ9CQA8 MM

Interactioni

Subunit structurei

Interacts with FGFR1OP; this interaction is required for its localization to the mother centriole. Interacts (via residues 121-150) with RABL2B. Interacts (via C-terminus) with CEP350; this interaction is required for its localization to the mother centriole.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the CEP19 family.Curated

Phylogenomic databases

eggNOGiENOG410IWEE Eukaryota
ENOG4111MS1 LUCA
GeneTreeiENSGT00390000016356
HOVERGENiHBG081009
InParanoidiQ9CQA8
KOiK16801
OMAiWDTESAD
OrthoDBiEOG091G0WDG
PhylomeDBiQ9CQA8
TreeFamiTF328425

Family and domain databases

InterProiView protein in InterPro
IPR029412 CEP19
PANTHERiPTHR31539 PTHR31539, 2 hits
PfamiView protein in Pfam
PF14933 CEP19, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYIAKKCGV RFQPPAVILI YENETEGKSR QRIMPVRNFS KFSDCTRAAE
60 70 80 90 100
QLKNNPRHKS YLEQVPLKQL EKLFVFLRGS LQGQSLAETM EQIRRETTID
110 120 130 140 150
PEEDLNKLDD KELAKRKSIM DELFEKNQKR KDDPTFVYDV EVEFPQDEQL
160
LSCSWDTASV DDF
Length:163
Mass (Da):19,170
Last modified:June 1, 2001 - v1
Checksum:iA7C8E26E4E5597E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005324 mRNA Translation: BAB23954.1
AK007713 mRNA Translation: BAB25206.1
BC023715 mRNA Translation: AAH23715.1
CCDSiCCDS28114.1
RefSeqiNP_080168.1, NM_025892.2
UniGeneiMm.22990

Genome annotation databases

EnsembliENSMUST00000042869; ENSMUSP00000046587; ENSMUSG00000035790
ENSMUST00000115168; ENSMUSP00000110822; ENSMUSG00000035790
ENSMUST00000169186; ENSMUSP00000126083; ENSMUSG00000035790
GeneIDi66994
KEGGimmu:66994
UCSCiuc007yyf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005324 mRNA Translation: BAB23954.1
AK007713 mRNA Translation: BAB25206.1
BC023715 mRNA Translation: AAH23715.1
CCDSiCCDS28114.1
RefSeqiNP_080168.1, NM_025892.2
UniGeneiMm.22990

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9CQA8
PhosphoSitePlusiQ9CQA8

Proteomic databases

PaxDbiQ9CQA8
PRIDEiQ9CQA8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042869; ENSMUSP00000046587; ENSMUSG00000035790
ENSMUST00000115168; ENSMUSP00000110822; ENSMUSG00000035790
ENSMUST00000169186; ENSMUSP00000126083; ENSMUSG00000035790
GeneIDi66994
KEGGimmu:66994
UCSCiuc007yyf.1 mouse

Organism-specific databases

CTDi84984
MGIiMGI:1914244 Cep19

Phylogenomic databases

eggNOGiENOG410IWEE Eukaryota
ENOG4111MS1 LUCA
GeneTreeiENSGT00390000016356
HOVERGENiHBG081009
InParanoidiQ9CQA8
KOiK16801
OMAiWDTESAD
OrthoDBiEOG091G0WDG
PhylomeDBiQ9CQA8
TreeFamiTF328425

Miscellaneous databases

PROiPR:Q9CQA8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035790 Expressed in 275 organ(s), highest expression level in visual cortex
CleanExiMM_1500031L02RIK
GenevisibleiQ9CQA8 MM

Family and domain databases

InterProiView protein in InterPro
IPR029412 CEP19
PANTHERiPTHR31539 PTHR31539, 2 hits
PfamiView protein in Pfam
PF14933 CEP19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEP19_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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