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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Sdhb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi100Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi103Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi115Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi188Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi191Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi194Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi198Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei203Ubiquinone; shared with DHSDBy similarity1
Metal bindingi245Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi251Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi255Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)
UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:Sdhb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914930 Sdhb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000001035631 – 282Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CQA3
MaxQBiQ9CQA3
PaxDbiQ9CQA3
PeptideAtlasiQ9CQA3
PRIDEiQ9CQA3

2D gel databases

REPRODUCTION-2DPAGEiQ9CQA3

PTM databases

iPTMnetiQ9CQA3
PhosphoSitePlusiQ9CQA3
SwissPalmiQ9CQA3

Expressioni

Gene expression databases

BgeeiENSMUSG00000009863 Expressed in 314 organ(s), highest expression level in cardiac ventricle
GenevisibleiQ9CQA3 MM

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

BioGridi212362, 4 interactors
ComplexPortaliCPX-562 Mitochondrial respiratory chain complex II
CORUMiQ9CQA3
IntActiQ9CQA3, 9 interactors
MINTiQ9CQA3
STRINGi10090.ENSMUSP00000010007

Structurei

3D structure databases

ProteinModelPortaliQ9CQA3
SMRiQ9CQA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 1352Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST94
Domaini178 – 2084Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
GeneTreeiENSGT00390000013558
HOGENOMiHOG000160590
HOVERGENiHBG005483
InParanoidiQ9CQA3
KOiK00235
OMAiDGQYFGP
OrthoDBiEOG091G0EKC
PhylomeDBiQ9CQA3
TreeFamiTF300754

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CQA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATVGVSLK RGFPAAVLGR VGLQFQACRG AQTAAAAAPR IKKFAIYRWD
60 70 80 90 100
PDKTGDKPRM QTYEVDLNKC GPMVLDALIK IKNEVDSTLT FRRSCREGIC
110 120 130 140 150
GSCAMNINGG NTLACTRRID TDLSKVSKIY PLPHMYVIKD LVPDLSNFYA
160 170 180 190 200
QYKSIEPYLK KKDESQEGKQ QYLQSIEDRE KLDGLYECIL CACCSTSCPS
210 220 230 240 250
YWWNGDKYLG PAVLMQAYRW MIDSRDDFTE ERLAKLQDPF SVYRCHTIMN
260 270 280
CTQTCPKGLN PGKAIAEIKK MMATYKEKRA LA
Length:282
Mass (Da):31,814
Last modified:June 1, 2001 - v1
Checksum:iA8616A911427AF8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40R → K in BAB22534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003052 mRNA Translation: BAB22534.1
AK003533 mRNA Translation: BAB22842.1
AK009660 mRNA Translation: BAB26422.1
AK153045 mRNA Translation: BAE31674.1
AK169252 mRNA Translation: BAE41016.1
BC013509 mRNA Translation: AAH13509.1
BC051934 mRNA Translation: AAH51934.1
CCDSiCCDS18858.1
PIRiPT0094
RefSeqiNP_075863.2, NM_023374.3
UniGeneiMm.246965

Genome annotation databases

EnsembliENSMUST00000010007; ENSMUSP00000010007; ENSMUSG00000009863
GeneIDi67680
KEGGimmu:67680
UCSCiuc008vnl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSDHB_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA3
Secondary accession number(s): Q3TF82, Q9DC91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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