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Protein

Centromere protein M

Gene

Cenpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Proliferation-associated nuclear element protein 1
Gene namesi
Name:Cenpm
Synonyms:Pane1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913820 Cenpm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582251 – 180Centromere protein MAdd BLAST180

Proteomic databases

PaxDbiQ9CQA0
PRIDEiQ9CQA0

PTM databases

PhosphoSitePlusiQ9CQA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000068101 Expressed in 121 organ(s), highest expression level in primary oocyte
CleanExiMM_CENPM
GenevisibleiQ9CQA0 MM

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CQA0, 1 interactor
MINTiQ9CQA0
STRINGi10090.ENSMUSP00000086560

Structurei

3D structure databases

ProteinModelPortaliQ9CQA0
SMRiQ9CQA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5U Eukaryota
ENOG4111PTI LUCA
GeneTreeiENSGT00390000017504
HOGENOMiHOG000261677
HOVERGENiHBG081086
InParanoidiQ9CQA0
KOiK11505
OMAiMLQICAG
OrthoDBiEOG091G0PZ0
PhylomeDBiQ9CQA0
TreeFamiTF328778

Family and domain databases

InterProiView protein in InterPro
IPR020987 Centromere_Cenp-M
PANTHERiPTHR34436 PTHR34436, 1 hit
PfamiView protein in Pfam
PF11111 CENP-M, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CQA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVLRSMDKL PDLNRATVLL VSTEDALLQQ LAESMLKDDC ASELRVHLAN
60 70 80 90 100
SLPLPSNVNR PRIDLIVFVI NLHSKYSLQK VEEFLQHVDS SFFLGKVCFL
110 120 130 140 150
VTGAGQESHC SVHQNTVIKL AHTYRSPLLL CDLQVESFRA AMARRLVRIL
160 170 180
QICAGHVPGV SALNLMSLLR SPENPPSKEL
Length:180
Mass (Da):20,039
Last modified:June 1, 2001 - v1
Checksum:iAA6396B75269346C
GO
Isoform 2 (identifier: Q9CQA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-180: AGQESHCSVH...SPENPPSKEL → GGKLSCSHGA...AASSKSSHCW

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):18,344
Checksum:i38E2649F47853431
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK17A0A2R8VK17_MOUSE
Centromere protein M
Cenpm
69Annotation score:
A0A2R8VI75A0A2R8VI75_MOUSE
Centromere protein M
Cenpm
116Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → M in BAE40163 (PubMed:16141072).Curated1
Sequence conflicti47H → N in BAE40163 (PubMed:16141072).Curated1
Sequence conflicti129L → F in AAH09160 (PubMed:15489334).Curated1
Sequence conflicti134Q → QK in AAH09160 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020440104 – 180AGQES…PSKEL → GGKLSCSHGAASGAHSADLR WPCARRLRAEPDVLAAEPRE PPIQGAVSITALHTFAASSK SSHCW in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243536 mRNA Translation: AAO62567.1
AY243537 mRNA Translation: AAO62568.1
AK010885 mRNA Translation: BAB27246.1
AK011191 mRNA Translation: BAB27456.1
AK011227 mRNA Translation: BAB27479.1
AK011464 mRNA Translation: BAB27635.1
AK011755 mRNA Translation: BAB27823.1
AK168203 mRNA Translation: BAE40163.1
AK017679 mRNA Translation: BAB30869.1
BC009160 mRNA Translation: AAH09160.1
CCDSiCCDS27685.1 [Q9CQA0-1]
CCDS37156.1 [Q9CQA0-2]
RefSeqiNP_001073627.1, NM_001080158.1
NP_079915.1, NM_025639.4 [Q9CQA0-1]
NP_840000.2, NM_178269.3 [Q9CQA0-2]
UniGeneiMm.23596

Genome annotation databases

EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101 [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101 [Q9CQA0-1]
GeneIDi66570
KEGGimmu:66570
UCSCiuc007wym.1 mouse [Q9CQA0-1]
uc007wyo.1 mouse [Q9CQA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY243536 mRNA Translation: AAO62567.1
AY243537 mRNA Translation: AAO62568.1
AK010885 mRNA Translation: BAB27246.1
AK011191 mRNA Translation: BAB27456.1
AK011227 mRNA Translation: BAB27479.1
AK011464 mRNA Translation: BAB27635.1
AK011755 mRNA Translation: BAB27823.1
AK168203 mRNA Translation: BAE40163.1
AK017679 mRNA Translation: BAB30869.1
BC009160 mRNA Translation: AAH09160.1
CCDSiCCDS27685.1 [Q9CQA0-1]
CCDS37156.1 [Q9CQA0-2]
RefSeqiNP_001073627.1, NM_001080158.1
NP_079915.1, NM_025639.4 [Q9CQA0-1]
NP_840000.2, NM_178269.3 [Q9CQA0-2]
UniGeneiMm.23596

3D structure databases

ProteinModelPortaliQ9CQA0
SMRiQ9CQA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CQA0, 1 interactor
MINTiQ9CQA0
STRINGi10090.ENSMUSP00000086560

PTM databases

PhosphoSitePlusiQ9CQA0

Proteomic databases

PaxDbiQ9CQA0
PRIDEiQ9CQA0

Protocols and materials databases

DNASUi66570
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089155; ENSMUSP00000086558; ENSMUSG00000068101 [Q9CQA0-2]
ENSMUST00000089157; ENSMUSP00000086560; ENSMUSG00000068101 [Q9CQA0-1]
GeneIDi66570
KEGGimmu:66570
UCSCiuc007wym.1 mouse [Q9CQA0-1]
uc007wyo.1 mouse [Q9CQA0-2]

Organism-specific databases

CTDi79019
MGIiMGI:1913820 Cenpm

Phylogenomic databases

eggNOGiENOG410IZ5U Eukaryota
ENOG4111PTI LUCA
GeneTreeiENSGT00390000017504
HOGENOMiHOG000261677
HOVERGENiHBG081086
InParanoidiQ9CQA0
KOiK11505
OMAiMLQICAG
OrthoDBiEOG091G0PZ0
PhylomeDBiQ9CQA0
TreeFamiTF328778

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

PROiPR:Q9CQA0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068101 Expressed in 121 organ(s), highest expression level in primary oocyte
CleanExiMM_CENPM
GenevisibleiQ9CQA0 MM

Family and domain databases

InterProiView protein in InterPro
IPR020987 Centromere_Cenp-M
PANTHERiPTHR34436 PTHR34436, 1 hit
PfamiView protein in Pfam
PF11111 CENP-M, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPM_MOUSE
AccessioniPrimary (citable) accession number: Q9CQA0
Secondary accession number(s): Q3THN3, Q91VS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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