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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Gene

Ndufa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Alternative name(s):
Complex I-B9
Short name:
CI-B9
NADH-ubiquinone oxidoreductase B9 subunit
Gene namesi
Name:Ndufa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913341 Ndufa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001187942 – 84NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CQ91
PaxDbiQ9CQ91
PeptideAtlasiQ9CQ91
PRIDEiQ9CQ91

PTM databases

PhosphoSitePlusiQ9CQ91

Expressioni

Gene expression databases

BgeeiENSMUSG00000035674 Expressed in 290 organ(s), highest expression level in cardiac muscle of left ventricle
ExpressionAtlasiQ9CQ91 baseline and differential
GenevisibleiQ9CQ91 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-266 Mitochondrial respiratory chain complex I
CORUMiQ9CQ91
STRINGi10090.ENSMUSP00000075953

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ9CQ91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA3 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J189 Eukaryota
ENOG411212S LUCA
GeneTreeiENSGT00390000004322
HOGENOMiHOG000015319
HOVERGENiHBG006495
InParanoidiQ9CQ91
KOiK03947
PhylomeDBiQ9CQ91
TreeFamiTF333021

Family and domain databases

InterProiView protein in InterPro
IPR026626 NDUFA3
PANTHERiPTHR15221 PTHR15221, 1 hit
PfamiView protein in Pfam
PF14987 NADHdh_A3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9CQ91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGRISAFLK NAWAKEPVLV VSFSVWGLAI IMPMISPYTK YASMINKATP
60 70 80
YNYPVPVRDD GNMPDVPSHP QDPLGPSLDW LKNL
Length:84
Mass (Da):9,331
Last modified:June 1, 2001 - v1
Checksum:iB05E59B217D95A92
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z670D3Z670_MOUSE
NADH dehydrogenase [ubiquinone] 1 a...
Ndufa3
100Annotation score:
F7BLS8F7BLS8_MOUSE
NADH dehydrogenase [ubiquinone] 1 a...
Ndufa3
42Annotation score:
D6RGT3D6RGT3_MOUSE
NADH dehydrogenase [ubiquinone] 1 a...
Ndufa3
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019099 mRNA Translation: BAB31545.1
AK003133 mRNA Translation: BAB22593.1
BC120712 mRNA Translation: AAI20713.1
BC120714 mRNA Translation: AAI20715.1
CCDSiCCDS39728.1
RefSeqiNP_079624.1, NM_025348.2
UniGeneiMm.17851

Genome annotation databases

EnsembliENSMUST00000076657; ENSMUSP00000075953; ENSMUSG00000035674
GeneIDi66091
KEGGimmu:66091
UCSCiuc009eve.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUA3_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ91
Secondary accession number(s): Q0VBA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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