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Protein

Centromere protein R

Gene

Itgb3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processApoptosis, Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein R
Short name:
CENP-R
Alternative name(s):
Nuclear receptor-interacting factor 3
Gene namesi
Name:Itgb3bp
Synonyms:Cenpr, Nrif3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914983 Itgb3bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579501 – 176Centromere protein RAdd BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei17PhosphoserineBy similarity1
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei28PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9CQ82
PeptideAtlasiQ9CQ82
PRIDEiQ9CQ82

PTM databases

iPTMnetiQ9CQ82
PhosphoSitePlusiQ9CQ82

Expressioni

Gene expression databases

BgeeiENSMUSG00000028549 Expressed in 212 organ(s), highest expression level in testis
CleanExiMM_ITGB3BP
GenevisibleiQ9CQ82 MM

Interactioni

Subunit structurei

Homodimer; mediated by the coiled coil domain. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117153

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 50DD1Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili82 – 112Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 66Nuclear localization signalBy similarity4
Motifi171 – 175LXXIL motif5

Domaini

The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis.By similarity
Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J05S Eukaryota
ENOG410Z43R LUCA
GeneTreeiENSGT00390000004336
HOGENOMiHOG000049271
HOVERGENiHBG080553
InParanoidiQ9CQ82
KOiK11510
OMAiCHLDSYE
OrthoDBiEOG091G180Q
PhylomeDBiQ9CQ82
TreeFamiTF336291

Family and domain databases

InterProiView protein in InterPro
IPR009601 CENP-R
PANTHERiPTHR15581 PTHR15581, 1 hit
PfamiView protein in Pfam
PF06729 CENP-R, 1 hit
PIRSFiPIRSF011860 NRIF3_coact_rcpt, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9CQ82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVKRSLKLD DQFEKNSFSP SKIVRKKSIT AYSPTTGTYQ LSPFSSPATP
60 70 80 90 100
KEQEHRNGPS NETRKRSNLS SPVRQESTVK DRDGFMVLLS KIEISSEKTM
110 120 130 140 150
EIMKNLSSIQ ALEGNRQLED LIGVSLVPCS LKSEARKTKE LMTKVIKQKL
160 170
FEKKKSRITP KDHHLDSFEF LKAILN
Length:176
Mass (Da):20,026
Last modified:June 1, 2001 - v1
Checksum:iB55F0C100CAE5973
GO
Isoform 2 (identifier: Q9CQ82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-84: TVKDRDG → MISLKKI

Note: No experimental confirmation available.
Show »
Length:99
Mass (Da):11,390
Checksum:i112AA4C302DED413
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → V in BAE38732 (PubMed:16141072).Curated1
Sequence conflicti50P → S in BAE38732 (PubMed:16141072).Curated1
Sequence conflicti82R → S in BAE38732 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0204531 – 77Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_02045478 – 84TVKDRDG → MISLKKI in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005779 mRNA Translation: BAB24235.1
AK013373 mRNA Translation: BAB28815.1
AK015557 mRNA Translation: BAB29892.1
AK045037 mRNA Translation: BAC32192.1
AK165072 mRNA Translation: BAE38024.1
AK166362 mRNA Translation: BAE38732.1
BC049557 mRNA Translation: AAH49557.1
CCDSiCCDS18387.1 [Q9CQ82-1]
RefSeqiNP_080624.1, NM_026348.3 [Q9CQ82-1]
UniGeneiMm.257094

Genome annotation databases

EnsembliENSMUST00000146258; ENSMUSP00000117153; ENSMUSG00000028549 [Q9CQ82-1]
ENSMUST00000230193; ENSMUSP00000154820; ENSMUSG00000115904 [Q9CQ82-1]
GeneIDi67733
KEGGimmu:67733
UCSCiuc008tux.1 mouse [Q9CQ82-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005779 mRNA Translation: BAB24235.1
AK013373 mRNA Translation: BAB28815.1
AK015557 mRNA Translation: BAB29892.1
AK045037 mRNA Translation: BAC32192.1
AK165072 mRNA Translation: BAE38024.1
AK166362 mRNA Translation: BAE38732.1
BC049557 mRNA Translation: AAH49557.1
CCDSiCCDS18387.1 [Q9CQ82-1]
RefSeqiNP_080624.1, NM_026348.3 [Q9CQ82-1]
UniGeneiMm.257094

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117153

PTM databases

iPTMnetiQ9CQ82
PhosphoSitePlusiQ9CQ82

Proteomic databases

PaxDbiQ9CQ82
PeptideAtlasiQ9CQ82
PRIDEiQ9CQ82

Protocols and materials databases

DNASUi67733
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146258; ENSMUSP00000117153; ENSMUSG00000028549 [Q9CQ82-1]
ENSMUST00000230193; ENSMUSP00000154820; ENSMUSG00000115904 [Q9CQ82-1]
GeneIDi67733
KEGGimmu:67733
UCSCiuc008tux.1 mouse [Q9CQ82-1]

Organism-specific databases

CTDi23421
MGIiMGI:1914983 Itgb3bp

Phylogenomic databases

eggNOGiENOG410J05S Eukaryota
ENOG410Z43R LUCA
GeneTreeiENSGT00390000004336
HOGENOMiHOG000049271
HOVERGENiHBG080553
InParanoidiQ9CQ82
KOiK11510
OMAiCHLDSYE
OrthoDBiEOG091G180Q
PhylomeDBiQ9CQ82
TreeFamiTF336291

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-205043 NRIF signals cell death from the nucleus
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

PROiPR:Q9CQ82
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028549 Expressed in 212 organ(s), highest expression level in testis
CleanExiMM_ITGB3BP
GenevisibleiQ9CQ82 MM

Family and domain databases

InterProiView protein in InterPro
IPR009601 CENP-R
PANTHERiPTHR15581 PTHR15581, 1 hit
PfamiView protein in Pfam
PF06729 CENP-R, 1 hit
PIRSFiPIRSF011860 NRIF3_coact_rcpt, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPR_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ82
Secondary accession number(s): Q3TLR0, Q3TNR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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