Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin domain-containing protein 9

Gene

Txndc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 9
Alternative name(s):
ATP-binding protein associated with cell differentiation
Gene namesi
Name:Txndc9
Synonyms:Apacd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138153 Txndc9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201671 – 226Thioredoxin domain-containing protein 9Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei223PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CQ79
MaxQBiQ9CQ79
PaxDbiQ9CQ79
PeptideAtlasiQ9CQ79
PRIDEiQ9CQ79

PTM databases

iPTMnetiQ9CQ79
PhosphoSitePlusiQ9CQ79

Expressioni

Tissue specificityi

Expressed in testis, liver, heart, kidney, brain, spleen and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000058407 Expressed in 282 organ(s), highest expression level in primary oocyte
CleanExiMM_TXNDC9
ExpressionAtlasiQ9CQ79 baseline and differential
GenevisibleiQ9CQ79 MM

Interactioni

Subunit structurei

Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072096

Structurei

3D structure databases

ProteinModelPortaliQ9CQ79
SMRiQ9CQ79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 180ThioredoxinAdd BLAST106

Phylogenomic databases

eggNOGiKOG1672 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00390000015645
HOGENOMiHOG000171916
HOVERGENiHBG054120
InParanoidiQ9CQ79
OrthoDBiEOG091G0RBF
PhylomeDBiQ9CQ79
TreeFamiTF313442

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9CQ79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGNGSVDMF SEVLENQFLQ AAKLVENHLD SEIQKLDQIG EDELELLKEK
60 70 80 90 100
RLAALRKAQQ QKQEWLSKGH GEYREIGSER DFFQEVKESE KVVCHFYRDT
110 120 130 140 150
TFRCKILDRH LAILAKKHLE TKFLKLNVEK APFLCERLRI KVIPTLALLR
160 170 180 190 200
DGKTQDYVVG FTDLGNTDDF TTETLEWRLG CSDVINYSGN LMEPPFQSQK
210 220
KFGTNFTKLE KKTIRGKKYD SDSDDD
Length:226
Mass (Da):26,260
Last modified:June 1, 2001 - v1
Checksum:iB90255DDAEE402BC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWP9A0A0A6YWP9_MOUSE
Thioredoxin domain-containing prote...
Txndc9
169Annotation score:
A0A0A6YXY0A0A0A6YXY0_MOUSE
Thioredoxin domain-containing prote...
Txndc9
188Annotation score:
A0A0A6YVV3A0A0A6YVV3_MOUSE
Thioredoxin domain-containing prote...
Txndc9
141Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002893 mRNA Translation: BAB22438.1
AK006170 mRNA Translation: BAB24440.1
AK010709 mRNA Translation: BAB27134.1
AK011424 mRNA Translation: BAB27611.1
AK016756 mRNA Translation: BAB30412.1
AK028525 mRNA Translation: BAC25991.1
AK153857 mRNA Translation: BAE32213.1
AK167045 mRNA Translation: BAE39213.1
BC022947 mRNA Translation: AAH22947.1
BC083077 mRNA Translation: AAH83077.1
CCDSiCCDS14898.1
RefSeqiNP_742051.1, NM_172054.4
XP_006496420.1, XM_006496357.3
XP_006496421.1, XM_006496358.3
UniGeneiMm.28438

Genome annotation databases

EnsembliENSMUST00000162031; ENSMUSP00000125491; ENSMUSG00000058407
ENSMUST00000195032; ENSMUSP00000141595; ENSMUSG00000058407
ENSMUST00000195247; ENSMUSP00000141609; ENSMUSG00000058407
GeneIDi98258
KEGGimmu:98258
UCSCiuc007asm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002893 mRNA Translation: BAB22438.1
AK006170 mRNA Translation: BAB24440.1
AK010709 mRNA Translation: BAB27134.1
AK011424 mRNA Translation: BAB27611.1
AK016756 mRNA Translation: BAB30412.1
AK028525 mRNA Translation: BAC25991.1
AK153857 mRNA Translation: BAE32213.1
AK167045 mRNA Translation: BAE39213.1
BC022947 mRNA Translation: AAH22947.1
BC083077 mRNA Translation: AAH83077.1
CCDSiCCDS14898.1
RefSeqiNP_742051.1, NM_172054.4
XP_006496420.1, XM_006496357.3
XP_006496421.1, XM_006496358.3
UniGeneiMm.28438

3D structure databases

ProteinModelPortaliQ9CQ79
SMRiQ9CQ79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072096

PTM databases

iPTMnetiQ9CQ79
PhosphoSitePlusiQ9CQ79

Proteomic databases

EPDiQ9CQ79
MaxQBiQ9CQ79
PaxDbiQ9CQ79
PeptideAtlasiQ9CQ79
PRIDEiQ9CQ79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162031; ENSMUSP00000125491; ENSMUSG00000058407
ENSMUST00000195032; ENSMUSP00000141595; ENSMUSG00000058407
ENSMUST00000195247; ENSMUSP00000141609; ENSMUSG00000058407
GeneIDi98258
KEGGimmu:98258
UCSCiuc007asm.1 mouse

Organism-specific databases

CTDi10190
MGIiMGI:2138153 Txndc9

Phylogenomic databases

eggNOGiKOG1672 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00390000015645
HOGENOMiHOG000171916
HOVERGENiHBG054120
InParanoidiQ9CQ79
OrthoDBiEOG091G0RBF
PhylomeDBiQ9CQ79
TreeFamiTF313442

Miscellaneous databases

PROiPR:Q9CQ79
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058407 Expressed in 282 organ(s), highest expression level in primary oocyte
CleanExiMM_TXNDC9
ExpressionAtlasiQ9CQ79 baseline and differential
GenevisibleiQ9CQ79 MM

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXND9_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ79
Secondary accession number(s): Q3TKD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again