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Protein

Leptin receptor overlapping transcript-like 1

Gene

Leprotl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leptin receptor overlapping transcript-like 1
Alternative name(s):
Endospanin-2
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915442 Leprotl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151981 – 131Leptin receptor overlapping transcript-like 1Add BLAST131

Proteomic databases

MaxQBiQ9CQ74
PaxDbiQ9CQ74
PRIDEiQ9CQ74

PTM databases

SwissPalmiQ9CQ74

Expressioni

Inductioni

Up-regulated in the liver of fasting animals.1 Publication

Gene expression databases

BgeeiENSMUSG00000031513 Expressed in 272 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_LEPROTL1
GenevisibleiQ9CQ74 MM

Interactioni

Subunit structurei

Interacts with RAB13.By similarity

Protein-protein interaction databases

BioGridi212717, 2 interactors
STRINGi10090.ENSMUSP00000033910

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2174 Eukaryota
ENOG4111UCZ LUCA
GeneTreeiENSGT00390000006503
HOGENOMiHOG000038515
HOVERGENiHBG001034
InParanoidiQ9CQ74
OMAiVIEWGAC
OrthoDBiEOG091G0V32
PhylomeDBiQ9CQ74
TreeFamiTF313689

Family and domain databases

InterProiView protein in InterPro
IPR007262 VPS55
PANTHERiPTHR12050 PTHR12050, 1 hit
PfamiView protein in Pfam
PF04133 Vps55, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CQ74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGIKALISL SFGGAIGLMF LMLGCALPIY NQYWPLFVLF FYILSPIPYC
60 70 80 90 100
IARRLVDDTD AMSNACKELA IFLTTGIVVS AFGLPVVFAR AHLIEWGACA
110 120 130
LVLTGNTVIF ATILGFFLVF GSNDDFSWQQ W
Length:131
Mass (Da):14,414
Last modified:June 1, 2001 - v1
Checksum:iBB168968DC440A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003329 mRNA Translation: BAB22717.1
AK013870 mRNA Translation: BAB29025.1
AK075740 mRNA Translation: BAC35921.1
AK150289 mRNA Translation: BAE29444.1
AK153277 mRNA Translation: BAE31863.1
AK159401 mRNA Translation: BAE35053.1
BC004677 mRNA Translation: AAH04677.1
CCDSiCCDS22239.1
RefSeqiNP_080885.1, NM_026609.2
UniGeneiMm.34212

Genome annotation databases

EnsembliENSMUST00000033910; ENSMUSP00000033910; ENSMUSG00000031513
GeneIDi68192
KEGGimmu:68192
UCSCiuc009lkp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLERL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ74
Secondary accession number(s): Q3U662
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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