Plakophilin 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-catenin binding Source: MGI
• cadherin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intermediate filament binding Source: MGI
• molecular adaptor activity Source: MGI
• protein kinase C binding Source: MGI

GO - Biological processⁱ

• adherens junction maintenance Source: MGI
• bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: MGI
• cardiac muscle cell action potential Source: MGI
• cardiac muscle cell action potential involved in contraction Source: MGI
• cell-cell adhesion Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation."
    Grossmann K.S., Grund C., Huelsken J., Behrend M., Erdmann B., Franke W.W., Birchmeier W.
    J Cell Biol 167:149-160(2004) [PubMed] [Europe PMC] [Abstract]
• cell-cell junction assembly Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling involved in cardiac conduction Source: MGI
• desmosome assembly Source: MGI
• desmosome organization Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• gap junction assembly Source: MGI
• heart development Source: MGIInferred from mutant phenotypeⁱ
  • "Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation."
    Grossmann K.S., Grund C., Huelsken J., Behrend M., Erdmann B., Franke W.W., Birchmeier W.
    J Cell Biol 167:149-160(2004) [PubMed] [Europe PMC] [Abstract]
• intermediate filament bundle assembly Source: MGI
• lipid homeostasis Source: MGI
• maintenance of animal organ identity Source: MGI
• negative regulation of cell migration Source: MGI
• negative regulation of cell population proliferation Source: MGI
• protein localization to plasma membrane Source: MGI
• regulation of bicellular tight junction assembly Source: MGI
• regulation of heart rate by cardiac conduction Source: MGI
• regulation of ventricular cardiac muscle cell action potential Source: MGI
• ventricular cardiac muscle cell action potential Source: MGI
• ventricular cardiac muscle tissue morphogenesis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• alpha-catenin binding Source: MGI
• cadherin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase C binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAVPGSLAEC GYIRTVLGQQ ILGHLDSSSL ALPSEARLRL AGSSGRGDPA 
        60         70         80         90        100
ARSQRIQEQV QQTLARRGRS SAVSGNLHRT SSVPEYVYKL HVVENDFVGR 
       110        120        130        140        150
QSPVTRDYDM LKAGMTATYG SRWGRAAAQY SSQKSVEERS WRQPLRRLEI 
       160        170        180        190        200
SPDSSPERAH YGHSEYQYAW RSHVVPGGRL TLPRYARSEI LGLRQAGTAR 
       210        220        230        240        250
RPPGCGSFSD AVFDNGPLKP TMPTHPPGTS HSAGSLLEET TVRVSQARLQ 
       260        270        280        290        300
STQSRTARSS WPRSSVRSSL REPGRMLTTA GQAAVGSGDA HGDRSVFADA 
       310        320        330        340        350
QLGNADIEMT LERAVNMLDA DHVPVSKISA AATFIQHESF QKSEARKRVN 
       360        370        380        390        400
QLRGIPKLLQ LLKLQNEDVQ RAACGALRNL VFEDNDNKLE VAELNGVPRL 
       410        420        430        440        450
LQVLKQTRDL ETKKQITGLL WNLSSSDKLK HLMITEALLT LTESVIIPFS 
       460        470        480        490        500
GWPEGDYPKA NGLLDFDIFY NVTGCLRNMS SAGPDGRKMM RRCDGLIDSL 
       510        520        530        540        550
VHYVRGTIAD YQPDDKATEN CVCILHNLSY QLEAELPEKY SQSIYMQNRN 
       560        570        580        590        600
IQTNSNKSIG CFGSRSRKLK EQYQDLQMPE ERSNPHGIEW LWHSIVIRMY 
       610        620        630        640        650
LSLIAKSTRN YTQEASLGAL QNLTAGGGPI PTLVARMVVQ KENGLQHTRK 
       660        670        680        690        700
MLHVGDPSVK KTAVSLLRNL SRNLSLQNEI AKETLPDLVS IIPDTVPSTD 
       710        720        730        740        750
LLIETTASAC YTLNNLMQNS YQNARDLLNT GGLQKIMTIS IGEGYAPNKA 
       760        770        780        790 
SKAASVLLYS LWAHTELHHA YKKAQFKKTD FVNSRTAKAY HSLKD      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ