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Protein

Cytochrome b-c1 complex subunit 8

Gene

Uqcrq

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:Uqcrq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107807 Uqcrq

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935451 – 82Cytochrome b-c1 complex subunit 8Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Modified residuei33N6-acetyllysine; alternateCombined sources1
Modified residuei33N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CQ69
MaxQBiQ9CQ69
PaxDbiQ9CQ69
PeptideAtlasiQ9CQ69
PRIDEiQ9CQ69
TopDownProteomicsiQ9CQ69

PTM databases

iPTMnetiQ9CQ69
PhosphoSitePlusiQ9CQ69

Expressioni

Gene expression databases

BgeeiENSMUSG00000044894 Expressed in 310 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ9CQ69 baseline and differential
GenevisibleiQ9CQ69 MM

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

BioGridi204458, 3 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9CQ69
IntActiQ9CQ69, 6 interactors
MINTiQ9CQ69
STRINGi10090.ENSMUSP00000053145

Structurei

3D structure databases

ProteinModelPortaliQ9CQ69
SMRiQ9CQ69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

eggNOGiKOG4116 Eukaryota
ENOG41123BH LUCA
GeneTreeiENSGT00390000004029
HOGENOMiHOG000205681
HOVERGENiHBG001468
InParanoidiQ9CQ69
KOiK00418
OMAiCILRVAP
OrthoDBiEOG091G13Z0
PhylomeDBiQ9CQ69
TreeFamiTF300281

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9CQ69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGREFGNLAR IRHVISYSLS PFEQRAFPSY FSKGIPNVLR RTRERILRVA
60 70 80
PPFVVVYLIY TWGNQEFEQS KRKNPAMYEN DK
Length:82
Mass (Da):9,768
Last modified:January 23, 2007 - v3
Checksum:iBE0E295EAA1BC23F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HPX6I7HPX6_MOUSE
Cytochrome b-c1 complex subunit 8
Uqcrq
37Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007982 mRNA Translation: BAB25388.1
AK002389 mRNA Translation: BAB22063.1
AK003160 mRNA Translation: BAB22613.1
AK005374 mRNA Translation: BAB23983.1
BC028519 mRNA Translation: AAH28519.1
CCDSiCCDS36151.1
RefSeqiNP_001313543.1, NM_001326614.1
NP_079628.1, NM_025352.3
UniGeneiMm.251621

Genome annotation databases

EnsembliENSMUST00000061326; ENSMUSP00000053145; ENSMUSG00000044894
ENSMUST00000109021; ENSMUSP00000104649; ENSMUSG00000044894
GeneIDi22272
KEGGimmu:22272
UCSCiuc007ivy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007982 mRNA Translation: BAB25388.1
AK002389 mRNA Translation: BAB22063.1
AK003160 mRNA Translation: BAB22613.1
AK005374 mRNA Translation: BAB23983.1
BC028519 mRNA Translation: AAH28519.1
CCDSiCCDS36151.1
RefSeqiNP_001313543.1, NM_001326614.1
NP_079628.1, NM_025352.3
UniGeneiMm.251621

3D structure databases

ProteinModelPortaliQ9CQ69
SMRiQ9CQ69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204458, 3 interactors
ComplexPortaliCPX-563 Mitochondrial respiratory chain complex III
CORUMiQ9CQ69
IntActiQ9CQ69, 6 interactors
MINTiQ9CQ69
STRINGi10090.ENSMUSP00000053145

PTM databases

iPTMnetiQ9CQ69
PhosphoSitePlusiQ9CQ69

Proteomic databases

EPDiQ9CQ69
MaxQBiQ9CQ69
PaxDbiQ9CQ69
PeptideAtlasiQ9CQ69
PRIDEiQ9CQ69
TopDownProteomicsiQ9CQ69

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061326; ENSMUSP00000053145; ENSMUSG00000044894
ENSMUST00000109021; ENSMUSP00000104649; ENSMUSG00000044894
GeneIDi22272
KEGGimmu:22272
UCSCiuc007ivy.2 mouse

Organism-specific databases

CTDi27089
MGIiMGI:107807 Uqcrq

Phylogenomic databases

eggNOGiKOG4116 Eukaryota
ENOG41123BH LUCA
GeneTreeiENSGT00390000004029
HOGENOMiHOG000205681
HOVERGENiHBG001468
InParanoidiQ9CQ69
KOiK00418
OMAiCILRVAP
OrthoDBiEOG091G13Z0
PhylomeDBiQ9CQ69
TreeFamiTF300281

Miscellaneous databases

PROiPR:Q9CQ69
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044894 Expressed in 310 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ9CQ69 baseline and differential
GenevisibleiQ9CQ69 MM

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR8_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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