Mtap

Functionⁱ

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityⁱ

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayⁱ: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

S-methyl-5'-thioadenosine phosphorylase (Mtap)

This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	18	PhosphateUniRule annotation	1
Siteⁱ	178	Important for substrate specificityUniRule annotation	1
Binding siteⁱ	196	Substrate; via amide nitrogenUniRule annotation	1
Binding siteⁱ	197	PhosphateUniRule annotation	1
Siteⁱ	233	Important for substrate specificityUniRule annotation	1

GO - Molecular functionⁱ

S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

L-methionine salvage from methylthioadenosine Source: UniProtKB-UniPathway
methylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22952318
purine ribonucleoside salvage Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Biological process	Purine salvage

Enzyme and pathway databases

BRENDAⁱ	2.4.2.28 3474
Reactomeⁱ	R-MMU-1237112 Methionine salvage pathway
UniPathwayⁱ	UPA00904; UER00873

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation) Alternative name(s): 5'-methylthioadenosine phosphorylaseUniRule annotation Short name: MTA phosphorylaseUniRule annotation Short name: MTAPUniRule annotation Short name: MTAPaseUniRule annotation
Gene namesⁱ	Name:Mtap
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1914152 Mtap

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2663

ChEMBLⁱ

CHEMBL2663

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184546	1 – 283	S-methyl-5'-thioadenosine phosphorylaseAdd BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	51	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9CQ65
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CQ65
PaxDbⁱ	Q9CQ65
PeptideAtlas More...PeptideAtlasⁱ	Q9CQ65
PRIDEⁱ	Q9CQ65

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9CQ65

REPRODUCTION-2DPAGEⁱ

Q9CQ65

PTM databases

iPTMnetⁱ	Q9CQ65
PhosphoSitePlusⁱ	Q9CQ65
SwissPalmⁱ	Q9CQ65

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000062937
CleanExⁱ	MM_MTAP
Genevisibleⁱ	Q9CQ65 MM

Interactionⁱ

Subunit structureⁱ

Homotrimer.UniRule annotation

Protein-protein interaction databases

BioGridⁱ	211799, 4 interactors
IntActⁱ	Q9CQ65, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9CQ65
STRINGⁱ	10090.ENSMUSP00000061092

Chemistry databases

BindingDBⁱ

Q9CQ65

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CQ65
SMRⁱ	Q9CQ65
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	60 – 61	Phosphate bindingUniRule annotation	2
Regionⁱ	93 – 94	Phosphate bindingUniRule annotation	2
Regionⁱ	220 – 222	Substrate bindingUniRule annotation	3

Sequence similaritiesⁱ

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3985 Eukaryota COG0005 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074874
HOGENOMⁱ	HOG000228986
HOVERGENⁱ	HBG002487
InParanoidⁱ	Q9CQ65
KEGG Orthology (KO) More...KOⁱ	K00772
OMAⁱ	NLYRSWG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CQI
PhylomeDBⁱ	Q9CQ65
TreeFamⁱ	TF312883

Family and domain databases

HAMAPⁱ	MF_01963 MTAP, 1 hit
InterProⁱ	View protein in InterPro IPR010044 MTAP IPR000845 Nucleoside_phosphorylase_d IPR035994 Nucleoside_phosphorylase_sf IPR018099 Purine_phosphorylase-2_CS
PANTHERⁱ	PTHR42679 PTHR42679, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01048 PNP_UDP_1, 1 hit
SUPFAMⁱ	SSF53167 SSF53167, 1 hit
TIGRFAMsⁱ	TIGR01694 MTAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS01240 PNP_MTAP_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9CQ65-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASGSACTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI 
        60         70         80         90        100
KNVDCVLLAR HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE 
       110        120        130        140        150
EIQPGDMVII DQFIDRTSLR PQTFYDGSHC SARGVCHIPM AEPFCPKTRE 
       160        170        180        190        200
VLIETAKKLG LRCHSKGTIV TIEGPRFSSR AESLIFRTWG ADVVNMTTVP 
       210        220        230        240        250
EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDGVLKTM KENANKAKSL 
       260        270        280 
LLTTIPQIGS MEWSETLRNL KNMAQFSVLP PRH

Length:283

Mass (Da):31,062

Last modified:June 1, 2001 - v1

Checksum:ⁱBF64441F41AE81EA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB056100 mRNA Translation: BAB32865.1 AK005064 mRNA Translation: BAB23788.1 AK011421 mRNA Translation: BAB27609.1 AK167319 mRNA Translation: BAE39421.1 BC003858 mRNA Translation: AAH03858.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18349.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077753.1, NM_024433.2
UniGeneⁱ	Mm.28500

Genome annotation databases

Ensemblⁱ	ENSMUST00000058030; ENSMUSP00000061092; ENSMUSG00000062937
GeneIDⁱ	66902
KEGGⁱ	mmu:66902
UCSC genome browser More...UCSCⁱ	uc008tof.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9CQ65	UPI00072E0E29		ACIJB		351
S-methyl-5'-thioadenosine phosphorylase		SAIBB		299
S-methyl-5'-thioadenosine phosphorylase		TARSY		290
UPI00038ECA88		CHILA		287
S-methyl-5'-thioadenosine phosphorylase		MACMU		286
+80

Protein	Similar proteins		Species	Score	Length
Q9CQ65	UPI00072E0E29		ACIJB		351
S-methyl-5'-thioadenosine phosphorylase		SAIBB		299
S-methyl-5'-thioadenosine phosphorylase		TARSY		290
UPI00038ECA88		CHILA		287
UPI0009058D31		PANPR		286
+139

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB056100 mRNA Translation: BAB32865.1 AK005064 mRNA Translation: BAB23788.1 AK011421 mRNA Translation: BAB27609.1 AK167319 mRNA Translation: BAE39421.1 BC003858 mRNA Translation: AAH03858.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18349.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077753.1, NM_024433.2
UniGeneⁱ	Mm.28500

3D structure databases

ProteinModelPortalⁱ	Q9CQ65
SMRⁱ	Q9CQ65
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211799, 4 interactors
IntActⁱ	Q9CQ65, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9CQ65
STRINGⁱ	10090.ENSMUSP00000061092

Chemistry databases

BindingDBⁱ	Q9CQ65
ChEMBLⁱ	CHEMBL2663

PTM databases

iPTMnetⁱ	Q9CQ65
PhosphoSitePlusⁱ	Q9CQ65
SwissPalmⁱ	Q9CQ65

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9CQ65

REPRODUCTION-2DPAGEⁱ

Q9CQ65

Proteomic databases

EPDⁱ	Q9CQ65
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CQ65
PaxDbⁱ	Q9CQ65
PeptideAtlas More...PeptideAtlasⁱ	Q9CQ65
PRIDEⁱ	Q9CQ65

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058030; ENSMUSP00000061092; ENSMUSG00000062937
GeneIDⁱ	66902
KEGGⁱ	mmu:66902
UCSC genome browser More...UCSCⁱ	uc008tof.2 mouse

Organism-specific databases

CTDⁱ	4507
MGIⁱ	MGI:1914152 Mtap

Phylogenomic databases

eggNOGⁱ	KOG3985 Eukaryota COG0005 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074874
HOGENOMⁱ	HOG000228986
HOVERGENⁱ	HBG002487
InParanoidⁱ	Q9CQ65
KEGG Orthology (KO) More...KOⁱ	K00772
OMAⁱ	NLYRSWG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CQI
PhylomeDBⁱ	Q9CQ65
TreeFamⁱ	TF312883

Enzyme and pathway databases

UniPathwayⁱ	UPA00904; UER00873
BRENDAⁱ	2.4.2.28 3474
Reactomeⁱ	R-MMU-1237112 Methionine salvage pathway

Miscellaneous databases

ChiTaRSⁱ	Mtap mouse
Protein Ontology More...PROⁱ	PR:Q9CQ65
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000062937
CleanExⁱ	MM_MTAP
Genevisibleⁱ	Q9CQ65 MM

Family and domain databases

HAMAPⁱ	MF_01963 MTAP, 1 hit
InterProⁱ	View protein in InterPro IPR010044 MTAP IPR000845 Nucleoside_phosphorylase_d IPR035994 Nucleoside_phosphorylase_sf IPR018099 Purine_phosphorylase-2_CS
PANTHERⁱ	PTHR42679 PTHR42679, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01048 PNP_UDP_1, 1 hit
SUPFAMⁱ	SSF53167 SSF53167, 1 hit
TIGRFAMsⁱ	TIGR01694 MTAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS01240 PNP_MTAP_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MTAP_MOUSE
Accessionⁱ	Q9CQ65Primary (citable) accession number: Q9CQ65 Secondary accession number(s): Q3TJS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 24, 2002
	Last sequence update:	June 1, 2001
	Last modified:	May 23, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9CQ65 (MTAP_MOUSE)

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S-methyl-5'-thioadenosine phosphorylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-methionine biosynthesis via salvage pathway

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Pathwayⁱ: L-methionine biosynthesis via salvage pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ