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Protein

Vesicle transport protein USE1

Gene

Use1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein USE1
Alternative name(s):
Protein D12
USE1-like protein
Gene namesi
Name:Use1
Synonyms:Use1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914273 Use1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 242CytoplasmicSequence analysisAdd BLAST242
Transmembranei243 – 263Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini264 – 270LumenalSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155801 – 270Vesicle transport protein USE1Add BLAST270

Proteomic databases

EPDiQ9CQ56
PaxDbiQ9CQ56
PRIDEiQ9CQ56

PTM databases

iPTMnetiQ9CQ56
PhosphoSitePlusiQ9CQ56

Expressioni

Gene expression databases

BgeeiENSMUSG00000002395 Expressed in 303 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9CQ56 baseline and differential
GenevisibleiQ9CQ56 MM

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211882, 5 interactors
STRINGi10090.ENSMUSP00000105680

Structurei

3D structure databases

ProteinModelPortaliQ9CQ56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 242Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the USE1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2678 Eukaryota
ENOG410ZN7C LUCA
GeneTreeiENSGT00390000014361
HOGENOMiHOG000007677
HOVERGENiHBG079328
InParanoidiQ9CQ56
KOiK08507
OMAiYKCWLWL
PhylomeDBiQ9CQ56
TreeFamiTF325006

Family and domain databases

InterProiView protein in InterPro
IPR019150 Vesicle_transport_protein_Use1
PANTHERiPTHR13050 PTHR13050, 1 hit
PfamiView protein in Pfam
PF09753 Use1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9CQ56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAEGAYHR PLATSRLELN LVRLLCRCES MAAEKREPDE WRLEKYVGAL
60 70 80 90 100
EDMLQALKVQ ASKPASEVIS EYSRKVDFLK GMLQAEKLTS SSEKALANQF
110 120 130 140 150
LAPGRVPTTA KERVPATKTV HLQSRARYTS EMRSELLGME PSGECEVDMR
160 170 180 190 200
KRAAKGSRPA DERQSASELD LVLQRHQGLQ EKLAEEMLGL ARSLKTNTLA
210 220 230 240 250
AQSVIKKDNQ TLSHSLKMAD QNLEKLKLES ERLEQHAQKS VNWLLWAMLI
260 270
VVCFVFISMI LFIRIMPRLK
Length:270
Mass (Da):30,594
Last modified:June 1, 2001 - v1
Checksum:iC2CEFCE54C7A30DB
GO
Isoform 2 (identifier: Q9CQ56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     153-153: A → AS

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,473
Checksum:iC85F570FF002B58B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q496E9Q496_MOUSE
Vesicle transport protein USE1
Use1
284Annotation score:
D3Z6D3D3Z6D3_MOUSE
Vesicle transport protein USE1
Use1
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → D in AAK26661 (Ref. 1) Curated1
Sequence conflicti38P → L in AAK26661 (Ref. 1) Curated1
Sequence conflicti194L → F in AAK26661 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126661 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_012667153A → AS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353245 mRNA Translation: AAK26661.1
AK008573 mRNA Translation: BAB25752.1
AK012490 mRNA Translation: BAB28275.1
AK160726 mRNA Translation: BAE35971.1
BC038519 mRNA Translation: AAH38519.1
BC075695 mRNA Translation: AAH75695.1
CCDSiCCDS22390.1 [Q9CQ56-1]
RefSeqiNP_001139252.1, NM_001145780.1
NP_080193.1, NM_025917.4 [Q9CQ56-1]
UniGeneiMm.41890

Genome annotation databases

EnsembliENSMUST00000019169; ENSMUSP00000019169; ENSMUSG00000002395 [Q9CQ56-1]
ENSMUST00000110054; ENSMUSP00000105681; ENSMUSG00000002395 [Q9CQ56-1]
GeneIDi67023
KEGGimmu:67023
UCSCiuc009mcp.2 mouse [Q9CQ56-1]
uc009mcs.2 mouse [Q9CQ56-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353245 mRNA Translation: AAK26661.1
AK008573 mRNA Translation: BAB25752.1
AK012490 mRNA Translation: BAB28275.1
AK160726 mRNA Translation: BAE35971.1
BC038519 mRNA Translation: AAH38519.1
BC075695 mRNA Translation: AAH75695.1
CCDSiCCDS22390.1 [Q9CQ56-1]
RefSeqiNP_001139252.1, NM_001145780.1
NP_080193.1, NM_025917.4 [Q9CQ56-1]
UniGeneiMm.41890

3D structure databases

ProteinModelPortaliQ9CQ56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211882, 5 interactors
STRINGi10090.ENSMUSP00000105680

PTM databases

iPTMnetiQ9CQ56
PhosphoSitePlusiQ9CQ56

Proteomic databases

EPDiQ9CQ56
PaxDbiQ9CQ56
PRIDEiQ9CQ56

Protocols and materials databases

DNASUi67023
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019169; ENSMUSP00000019169; ENSMUSG00000002395 [Q9CQ56-1]
ENSMUST00000110054; ENSMUSP00000105681; ENSMUSG00000002395 [Q9CQ56-1]
GeneIDi67023
KEGGimmu:67023
UCSCiuc009mcp.2 mouse [Q9CQ56-1]
uc009mcs.2 mouse [Q9CQ56-2]

Organism-specific databases

CTDi55850
MGIiMGI:1914273 Use1

Phylogenomic databases

eggNOGiKOG2678 Eukaryota
ENOG410ZN7C LUCA
GeneTreeiENSGT00390000014361
HOGENOMiHOG000007677
HOVERGENiHBG079328
InParanoidiQ9CQ56
KOiK08507
OMAiYKCWLWL
PhylomeDBiQ9CQ56
TreeFamiTF325006

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q9CQ56
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002395 Expressed in 303 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9CQ56 baseline and differential
GenevisibleiQ9CQ56 MM

Family and domain databases

InterProiView protein in InterPro
IPR019150 Vesicle_transport_protein_Use1
PANTHERiPTHR13050 PTHR13050, 1 hit
PfamiView protein in Pfam
PF09753 Use1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUSE1_MOUSE
AccessioniPrimary (citable) accession number: Q9CQ56
Secondary accession number(s): Q3TUK0, Q80V73, Q99MB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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